In this paper, we establish some Lyapunov-type inequalities for a class of linear and nonlinear fractional q-difference boundary value problems under Cauchy boundary conditions. As applications, we use the inequality to obtain an interval, where Mittag-Leffler function has no real zeros. In addition, we also derive nonexistence results for fractional q-difference boundary value problem.MSC: 26D15; 65L10; 39A13; 26A33; 33E12