LY171883 preserves mesenteric perfusion in porcine endotoxic shock

Cohn, Stephen M.; Fink, Mitchell P.; Lee, Patrick; Wang, Hailong; Rothschild, Heidie R.; Deniz, Yamo F.; Baum, Tad D.

doi:10.1016/0022-4804(90)90108-e

Cited by 16 publications

(1 citation statement)

References 31 publications

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“…All have been found to be potent mesenteric vasoconstrictors in different animal models. 33,34 Complement activation with the release of C3a and C5a induces increased vascular permeability, vasoconstriction, neutrophil activation, and cytokine expression (tumour necrosis factor (TNF), interleukins IL-1, -6 and -8). TNF and IL-1 induce vasodilatation and expression of specific adhesion molecules, such as Eselectin and intercellular adhesion molecule-1 (ICAM-1), which promote adhesion of leukocytes to endothelial cells (rolling and margination) prior to ingress into tissues to cause neutrophil-mediated damage.…”

Section: Inflammation and Mesenteric Vasomotionmentioning

confidence: 99%

Gastrointestinal Dysfunction Following Cardiac Surgery

Ohri

Velissaris

2006

Perfusion

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Cardiac surgery is associated with a low incidence of GI complications, but with a disproportionate mortality. A number of risk factors have become established which identify patients at risk. CPB is associated with profound reductions in mucosal blood flow. Mesenteric perfusion is altered by primary endothelial dysfunction, which may further be exacerbated by the use of vasoconstrictors during CPB; inflammatory mediators can 'prime' the mesenteric vasculature. Cardiac surgery with or without CPB is associated with increased tissue oxygen demands, particularly by the splanchnic bed. The disparity in general and regional oxygen supply and demand results in the development of mucosal hypoxia and this cannot be attributed to CPB alone. This injury is measurable by reductions in both absorptive and barrier functions of the gut. Protection may be conferred by modulating the perfusion protocol during bypass and pharmacological interventions which modify the inflammatory response to surgery.

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Section: Inflammation and Mesenteric Vasomotionmentioning

confidence: 99%