1940

DOI: 10.1001/archderm.1940.01490080070004

|View full text |Cite

|

Sign up to set email alerts

|

Lxxxviii.—a Search for Filtrable Viruses in Cutaneous Diseases of Unknown Etiology

Floyd S. Markham¹

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Evidence Against An Infectious Aetiology1

Viral Studies In Pr1

Discussion1

Introduction1

Citation Types

Supporting

0

Mentioning

4

Contrasting

0

Year Published

1948

1948

2004

2004

Publication Types

Select...

Article7

Relationship

Self Cite0

Independent7

Authors

Journals

Cited by 9 publications

(4 citation statements)

References 2 publications

Supporting

0

Mentioning

4

Contrasting

0

Order By: Relevance

“…Repeated attempts [52,[63][64][65] to isolate a virus by inoculating lesional biopsy specimens, blood, pharyngeal and rectal swabs with various cell lines failed to confirm a cytopathic effect and failed to demonstrate viral antigens by immunofluorescence assays [66]. Two studies by electron microscopy [52,67] also reported absence of viral particles from lesional biopsy specimens of patients with PR.…”

Section: Evidence Against An Infectious Aetiologymentioning

confidence: 99%

Pityriasis rosea evidence for and against an infectious aetiology

¹

,

²

,

2004

Epidemiol. Infect.

View full text Add to dashboard Cite

Pityriasis rosea, first named as such in 1860, probably holds the longest record for an exanthem suspected to be associated with an infection but for which an exact cause has not been found. The distinctly programmed clinical course, the lack of recurrence for most patients, and the presence of temporal case clustering provide the strongest evidence to support an infectious aetiology. Further support comes from seasonal variation and the association with respiratory tract infections, the unfavourable social and economic background of cases, and a history in some cases of contact with patients with pityriasis rosea. The apparent therapeutic efficacy of several treatment modalities does not provide strong evidence for or against an infectious aetiology. The roles of human herpesvirus 7 and to a lesser extent human herpesvirus 6 remain controversial. There exists reasonable evidence that pityriasis rosea is not associated with cytomegalovirus, Epstein-Barr virus, parvovirus B19, picornavirus, influenza and parainfluenza viruses, Legionella spp., Mycoplasma spp. and Chlamydia spp. infections. Evidence is also unsubstantiated as yet for alternative aetiological hypotheses such as autoimmunity, atopy, and genetic predisposition.

“…Repeated attempts [52,[63][64][65] to isolate a virus by inoculating lesional biopsy specimens, blood, pharyngeal and rectal swabs with various cell lines failed to confirm a cytopathic effect and failed to demonstrate viral antigens by immunofluorescence assays [66]. Two studies by electron microscopy [52,67] also reported absence of viral particles from lesional biopsy specimens of patients with PR.…”

Section: Evidence Against An Infectious Aetiologymentioning

confidence: 99%

Pityriasis rosea evidence for and against an infectious aetiology

¹

,

²

,

2004

Epidemiol. Infect.

View full text Add to dashboard Cite

Pityriasis rosea, first named as such in 1860, probably holds the longest record for an exanthem suspected to be associated with an infection but for which an exact cause has not been found. The distinctly programmed clinical course, the lack of recurrence for most patients, and the presence of temporal case clustering provide the strongest evidence to support an infectious aetiology. Further support comes from seasonal variation and the association with respiratory tract infections, the unfavourable social and economic background of cases, and a history in some cases of contact with patients with pityriasis rosea. The apparent therapeutic efficacy of several treatment modalities does not provide strong evidence for or against an infectious aetiology. The roles of human herpesvirus 7 and to a lesser extent human herpesvirus 6 remain controversial. There exists reasonable evidence that pityriasis rosea is not associated with cytomegalovirus, Epstein-Barr virus, parvovirus B19, picornavirus, influenza and parainfluenza viruses, Legionella spp., Mycoplasma spp. and Chlamydia spp. infections. Evidence is also unsubstantiated as yet for alternative aetiological hypotheses such as autoimmunity, atopy, and genetic predisposition.

“…Attempts to isolate the PR virus by inoculating PR biopsies, blood, pharyngeal and rectal swab eluates with various cell lines failed to demonstrate a cytopathic effect or the presence of viral antigens by immunofluorescence assays [9,21,36,64]. In 1968, Raskin reported that cultured African green monkey kidney cells showed a cytopathic effect upon inoculation with scales and skin biopsies from both, the herald patch and secondary PR lesions [49].…”

Section: Viral Studies In Prmentioning

confidence: 99%

Pityriasis rosea - a virus-induced skin disease? An update

¹

,

²

2000

Archives of Virology

View full text Add to dashboard Cite

Pityriasis rosea (PR) is an acute, inflammatory skin disease of unknown cause. Clinical and experimental findings indicate an infectious etiology of PR. Various infectious agents including viruses have been proposed as causative agents and their presence in PR samples has been extensively investigated. Recently, human herpesvirus 7 was linked to PR, but contradictory findings have been reported by various investigators. Here, we describe the features of PR that suggest an infectious cause and review the data from viral studies in PR reported in the literature. In addition, we present a pathogenetic model of PR which may be helpful in planning and evaluating studies for the search of a putative PR-associated virus. Based on the current state of knowledge, none of the known viruses could, so far, be conclusively associated with PR.

“…The cause of pityriasis rosea remains unknown. The possibility of viral origin has long been suspected, but to date no supportive evidence has been demonstrated (5)(6)(7)(8). In 1968 Raskin (9) reported a successful attempt to detect viral agents in materials obtained from patients by inoculation to African green monkey kidney cells.…”

Section: Discussionmentioning

confidence: 99%

Immunological Studies of Pityriasis Rosea (Gibert)

¹

,

²

,

³

1977

The Journal of Dermatology

View full text Add to dashboard Cite

In order to elucidate the immunological mechanism in the pathogenesis of pityriasis rosea, immunofluorescent studies were performed on sera obtained from forty patients with this disease. Antibodies against the cytoplasm of normal human epidermal cells were demonstrated in the sera of all patients. The antibody titer showed a tendency to increase within 3 weeks after onset of secondary eruptions and then to decrease gradually until the period of recovery. The immunoglobulin class was determined to be IgM. Furthermore, by the direct immunofluorescent technique, deposits of IgM in the epidermal cells of skin lesions were demonstrated in 3 of 6 herald lesions and in 1 of 4 secondary eruptions. It is suggested that anti-cytoplasmic antibodies produced by some unknown cause may induce the development of secondary eruptions of this disease.

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Product

Browser Extension Assistant by scite Citation Statement Search Reference Check Visualizations Dashboards Explore Journals Explore Organizations Explore Funders Embedding Badge Embedding Citation Search Pricing

Resources

Blog Help & FAQ Accessibility Statement API Terms For Universities & Governments For Researchers For Publishers For Corporate, Pharma & Enterprise Author Marketing Become an Affiliate Get an organization trial or quote scite Data & Services

About

News & Press Careers Read our Paper Coverage

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Copyright © 2024 scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.