Lxi.—lipids of the Skin

Kooyman, D. J.

doi:10.1001/archderm.1932.01450020460003

Cited by 75 publications

(2 citation statements)

References 8 publications

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“…The first chemical observation ofesterified cholesterol in human epidermis was reported by Unna & Goldsdetz (1910), who suggested that a relationship exists between esterification of cholesterol and keratinization. In confirmation of these early observations, Kooyman (1932) reported, after the analysis of different layers of human epidermis, that esterified cholesterol was predominantly localized in the stratum corneum, whereas phospholipids were found mainly in the basal layer. These observations led to the suggestion that cholesterol esters in the stratum corneum originated from the esterification of cholesterol with fatty acids derived possibly from the tissue phospholipids.…”

supporting

confidence: 58%

Biosynthesis and hydrolysis of cholesteryl esters by rat skin subcellular fractions. Regulation by prostaglandins

Ziboh

Dreize

1975

Biochemical Journal

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The properties and subcellular distribution of the enzymes involved with the synthesis and hydrolysis of cholesteryl esters were investigated in skin of normal and essential fatty acid-deficient rats. Most of the activity of the cholesterol-esterifying enzyme(s) is associated with the 12000g and 105000g particulate fractions. The dependence of the enzyme reaction on ATP and CoA suggests that the esterification of cholesterol by rat skin is mediated by a fatty acyl-CoA-cholesterol acyltransferase (EC 2.3.1.-). On the other hand, most of the activity of the cholesteryl ester hydrolase (EC 3.1.1.13) is localized in the 105000g supernatant fraction. Although the activity of the cholesterol-esterifying enzyme(s) was elevated in skin preparations from essential fatty acid-deficient rats, the activity of the hydrolase was significantly decreased. These observations may explain in part the elevated concentrations of sterol esters in the skin of these animals. Prostaglandin E(2) at low concentrations exerted marked inhibitory effect on the activity of the cholesterol-esterifying enzyme(s), whereas no effect was observed on the activity of the hydrolase at similar concentrations. However, at high concentrations prostaglandin E(2) exerted moderate stimulatory effect on the activity of the hydrolase. These results suggest a possible physiological role of this substance in regulating the production of sterol esters in this tissue.

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confidence: 58%

Biosynthesis and hydrolysis of cholesteryl esters by rat skin subcellular fractions. Regulation by prostaglandins

Ziboh

Dreize

1975

Biochemical Journal

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“…The results of our present study arc consistent with those so far reponed in that the epidermal cyst lacks squalene, but contains cholesterol and cholesteryl ester at a higher rate. It has been reported that epidermal cholesterol is esterified to produce cholesteryl ester (4,5), and also that the ratio of esterified components to total cholesterol in the uppermost stratum corneum is 20 (2) or 30.5 (6). In this regard, the fact that the proportion of esterified components in the epidermal cyst content cholesterol was 20 % in our present study also indicates that these components are similar to those of the corneum of the epidermis.…”

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confidence: 99%

Analysis of the Lipids From the Contents of an Epidermal Cyst

Otsuka

Kukita

Seyama

et al. 1982

The Journal of Dermatology

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The lipids from the contents of an epidermal cyst were analysed quantitatively. Cholesteryl ester, triglyceride, free fatty acids, cholesterol, ceramide and some phospholipids were determined.Fatty acid components of some lipids (cholesteryl ester, triglyceride, free fatty acids and ceramide) were also analysed. The fatty acid component of ceramide included a high proportion of long chain fatty acids. The fatty acid portion of cholesteryl ester contained a relatively larger proportion of odd numbered, straight chained monoenes (C l7 : 1 etc), which were also found in ceramide at a lower concentration. The odd numbered monoene, C l7 : 1 in which the double bond is located at L19, was considered to be an intrinsic component of epidermal cyst contents.The lipid pattern and fatty acid compositions of the lipids of the contents from an epidermal cyst were similar to those of the human epidermal corneum.

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Nature of Skin Lipids in Acne

Kile¹

1950

Arch Dermatol

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Lxi.—lipids of the Skin

Cited by 75 publications

References 8 publications

Biosynthesis and hydrolysis of cholesteryl esters by rat skin subcellular fractions. Regulation by prostaglandins

Biosynthesis and hydrolysis of cholesteryl esters by rat skin subcellular fractions. Regulation by prostaglandins

Analysis of the Lipids From the Contents of an Epidermal Cyst

Nature of Skin Lipids in Acne

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