Lutzomyia migonei as putative vector of visceral leishmaniasis in La Banda, Argentina

Salomón, Oscar Daniel; Quintana, María Gabriela; Bezzi, Gisella; Morán, María L.; Betbeder, Eduardo; Valdez, Daniel

doi:10.1016/j.actatropica.2009.08.024

Cited by 75 publications

(59 citation statements)

References 23 publications

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“…Recently, this species was also implicated as a vector of visceral leishmaniasis (Leishmania infantum) in Argentina (40). In Venezuela, Lutzomyia ovallesi is the primary vector of cutaneous leishmaniasis (L. braziliensis) in the north-central area of Venezuela (41,42).…”

Section: Resultsmentioning

confidence: 99%

Las glándulas salivales de dos flebotominos vectores de Leishmania: Lutzomyia migonei (França) y Lutzomyia ovallesi (Ortiz) (Diptera: Psychodidae)

et al. 2010

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Introduction. Leishmaniasis is a vector-borne disease transmitted by the intradermal inoculation of Leishmania (Kinetoplastida: Trypanosomatidae) promastigotes together with saliva during the bite of an infected sand fly. Objective. The salivary glands were compared from two vector species, Lutzomyia ovallesi (Ortiz,1952) and Lutzomyia migonei (França,1920) (Diptera: Psychodidae). Material and methods. Protein profiles by SDS PAGE of salivary glands were compared among species as well as their development at several times post feeding. First, mice were immunized to salivary proteins by exposure to biting by L. ovallesi and of L. migonei. Antibodies in these mice against salivary gland-specific proteins were evaluated by immunoblotting. Results. No apparent change was revealed in the kinetic expression of salivary proteins induced by the different physiological states post feeding. Qualitative and quantitative variations were detected in16-18 polypeptides with molecular weights ranging from 6 to 180 kDa. Species-specific proteins were demonstrated for L. migonei and L. ovallesi. In addition, antibodies against salivary gland specific proteins were found in mice immunized by the saliva of both species. Conclusion. Basic information was obtained concerning the nature of salivary gland proteins of L. migonei and L. ovallesi. This information helps to elucidate the role of salivary proteins and their potential as effective tools in screening risk factors in human and other vertebrate hosts.

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Section: Resultsmentioning

confidence: 99%

Las glándulas salivales de dos flebotominos vectores de Leishmania: Lutzomyia migonei (França) y Lutzomyia ovallesi (Ortiz) (Diptera: Psychodidae)

et al. 2010

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“…La dispersión por trán-sito y tráfico de mascotas ha generado la presencia de perros infectados, el principal reservorio urbano, en gran parte del territorio nacional. El vector urbano es Lutzomyia longipalpis y en la región del Chaco participaría Migonemyia migonei (3)(4)(5)(6).…”

Section: Introductionunclassified

Leishmaniasis visceral: senderos que confluyen, se bifurcan

Salomón

Mastrángelo²,

Santini

et al. 2012

Salud Colectiva

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artícuLo / ArTICLE resumen La leishmaniasis visceral urbana es una zoonosis emergente en Argentina.En América es producida por Leishmania infantum, con el perro como reservorio principal e insectos flebotomíneos como vectores. En este artículo se presenta el conocimiento acumulado a partir de su emergencia y dispersión en el país, por los referentes del Programa Nacional de Leishmaniasis, en el diagnóstico clínico y de laboratorio, tratamiento, biología de vectores, manejo de reservorio, y el conflicto generado con las acciones recomendadas en relación con los perros infectados. La detección temprana y el tratamiento precoz, con estrategias descentralizadas y horizontales, contribuirán a disminuir la morbimortalidad asociada a la leishmaniasis visceral. El control de su transmisión y dispersión requiere de un manejo ambiental integral y la tenencia responsable de perros. Se discuten los intereses y discursos en conflicto generados por la leishmaniasis visceral en el marco de la relación humano-perro, proponiendo la búsqueda de un discurso consensuado de riesgo.paLabras cLave Leishmania infantum; Lutzomyia longipalpis; Diagnóstico; Medicina Clínica; Percepción Social; Mascotas.abstract Urban visceral leishmaniasis is an emerging zoonosis in Argentina. In the Americas the disease is produced by Leishmania infantum, with dogs as the primary reservoir and phlebotomine sandflies as the vectors. This article presents the experience acquired by professionals from the National Leishmaniasis Program in Argentina as visceral leishmaniasis has emerged and spread, especially in clinical and laboratory diagnosis, disease treatment, vector biology, reservoir management, and conflicts regarding recommendations for infected dogs. Early detection and treatment, along with decentralized and horizontal strategies, will contribute to the decrease in morbidity and mortality associated with visceral leishmaniasis. Control over the transmission and spread of the disease requires integral environmental management and responsible dog ownership. The interests and discourses put into conflict by visceral leishmaniasis are discussed in the framework of the human-dog relationship, and the search for a consensus-based risk discourse is proposed.

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“…Lutzomyia migonei França is among the main vectors in the Venezuelan Andean region (Nieves et al 2008). L. migonei is an anthropophilic sandfly that is widely distributed in the American continent and is blamed for transmitting skin leishmaniasis in Venezuela and Brazil, as well as visceral leishmaniasis in Argentina (Nieves et al 2008;Salomón et al 2010). At present, there is no efficient control system available against leishmaniasis.…”

Section: Introductionmentioning

confidence: 99%

Adulticide effect of Monticalia greenmaniana (Asteraceae) against Lutzomyia migonei (Diptera: Psychodidae)

et al. 2012

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Leishmaniasis is a public health problem that has been increasing year by year, with the further difficulty that an efficient control system is not available. Therefore, it is necessary to search for less contaminating and dangerous alternatives for controlling Leishmania transmitting sandflies. The purpose of this study was to evaluate the activity of Monticalia greenmaniana (Asteraceae) extracts and essential oil as an adulticide against Lutzomyia migonei (Diptera: Psychodidae) females, from a laboratory colony, in experimental conditions. Dry aerial parts of M. greenmaniana (Hieron) Jeffrey were used. Methanolic and aqueous extracts were prepared, and essential oil was obtained by hydrodistillation. Adulticide tests in pots, adulticide tests in cages, and knocked-down effects were determined. The results obtained demonstrated that methanolic and aqueous extracts produced adulticide activity. The essential oil from M. greenmaniana was proved to be the most toxic against L. migonei, with a 95 % death rate at a concentration of 0.01 mg/ml during a 1-h exposure. The essential oil showed a DL50 = 0.0050 and DL98 = 0.0066 mg/ml. The methanolic extract was DL50 = 0.130 and DL98 = 1.016 mg/ml, and the aqueous extract, DL50 = 0.487 and DL98 10.924 mg/ml. The knocked-down effect for the M. greenmaniana oil showed a KDTL50 = 48.6 and KDTL98 = 90.1 min. It was concluded that the essential oil from M. greenmaniana showed a strong insecticide effect against L. migonei females, which encourages us to continue these studies in search for control alternatives against sandflies.

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Lutzomyia migonei as putative vector of visceral leishmaniasis in La Banda, Argentina

Cited by 75 publications

References 23 publications

Las glándulas salivales de dos flebotominos vectores de Leishmania: Lutzomyia migonei (França) y Lutzomyia ovallesi (Ortiz) (Diptera: Psychodidae)

Las glándulas salivales de dos flebotominos vectores de Leishmania: Lutzomyia migonei (França) y Lutzomyia ovallesi (Ortiz) (Diptera: Psychodidae)

Leishmaniasis visceral: senderos que confluyen, se bifurcan

Adulticide effect of Monticalia greenmaniana (Asteraceae) against Lutzomyia migonei (Diptera: Psychodidae)

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