Luteolytic and luteotrophic effects of oestrogen in the guinea-pig

Dv, Illingworth

doi:10.1530/jrf.0.0180548

Cited by 5 publications

(4 citation statements)

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“…Luteal size, progesterone content and plasma progesterone levels were within the expected limits for untreated hysterectomized animals at a similar time after ovulation. The results obtained with stilboestrol, ECP and oestradiol propionate confirmed the work of the other groups and the earlier study using stilboestrol (Illingworth, 1969).…”

Section: Resultssupporting

confidence: 90%

“…In a preliminary investigation, Illingworth (1969) showed that oestrogen administered late in the cycle was not lytic, and prevented the regression of the CL. This luteotrophic effect has been reported in several species, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…This lytic effect of oestrogen could be abolished by hysterectomy (Bland & Donovan, 1968) or hypophysectomy (Illingworth, 1969) or FSH treatment (Choudary & Greenwald, 1969). Two contrasting mechanisms of oestrogen action have been proposed : activation of the uterine luteolytic factor (Bland & Donovan, 1970) or inhibition of essential luteotrophin secretion (Choudary & Greenwald, 1969).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Oestrogen, Administered Early or Late in the Oestrous Cycle, Upon the Survival and Regression of the Corpus Luteum of the Guinea-Pig

Illingworth¹,

Perry²

1973

Reproduction

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The lytic effect of oestrogen administered within the first 5 days of ovulation in the guinea-pig can be abolished by hysterectomy and is greatly reduced by hypophysectomy. After Day 9 of the cycle, large doses of oestrogen resulted in the maintenance of the CL for at least 3 weeks after ovulation, and in many instances for more than 4 weeks, and their further growth to sizes seen after hysterectomy or during pregnancy (3\ m=. \ 2 \ m=+-\ 0\m=.\3 mm3). These large CL contained and secreted more progesterone than those of the normal cycle. Hypophysectomy did not abolish the antiluteolytic effect of oestrogen. A luteotrophic, not solely an antiluteolytic, effect of the hormone could be demonstrated. The luteolytic or luteotrophic action of oestrogen did not depend upon the age of the CL but upon pituitary and/or uterine factors. The study used mainly stilboestrol, but similar results were obtained with oestradiol compounds.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Oestrogen, Administered Early or Late in the Oestrous Cycle, Upon the Survival and Regression of the Corpus Luteum of the Guinea-Pig

Illingworth¹,

Perry²

1973

Reproduction

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“…There is evidence that, in guinea-pigs, oestrogen given early in pregnancy or the oestrous cycle (Kelly, 1931;Rowlands, 1962;Spies et ai, 1964;Choudary & Greenwald, 1968;Illingworth, 1969;Bland & Donovan, 1970) and clomiphene given early in the oestrous cycle (Meckley & Ginther, 1972;Westfahl, 1989) cause luteal regression, as measured directly or by observations of behavioural or vaginal oestrus 10-13 days after treatment. This latter period is similar to the shortening of the oestrous cycle obtained by Loeb (1911) and Dempsey (1937) (Sgarlata et ai, 1984).…”

Section: Discussionmentioning

confidence: 99%

Effects of clomiphene citrate on early pregnancy in guinea-pigs

Motta

Hutchinson²

1991

Reproduction

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Summary. Clomiphene citrate (2 mg/kg body wt) given on the day of mating can block or interrupt pregnancy in guinea-pigs. Corpus luteum function, uterine histology, implantation and embryo development were studied in clomiphene-treated and control animals on Days 5, 9 and 20 of pregnancy. Following treatment, only 25% of the females were regularly pregnant, presenting large and healthy foetuses. The other females examined showed either pregnancy with embryos undergoing resorption or no sign of pregnancy. In these females, corpus luteum size was reduced, progesterone concentrations were very low and the endometrial glands and the epithelium were often altered. It is concluded that clomiphene causes a reduction in fertility by altering the uterus and, by directly or indirectly inducing luteolysis, causes later pregnancy loss.

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Physiology and pharmacology of female reproduction under the aspect of fertility control

Elger¹

Ergebnisse Der Physiologie Reviews of Physiology

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Luteolytic and luteotrophic effects of oestrogen in the guinea-pig

Cited by 5 publications

References 0 publications

Effects of Oestrogen, Administered Early or Late in the Oestrous Cycle, Upon the Survival and Regression of the Corpus Luteum of the Guinea-Pig

Effects of Oestrogen, Administered Early or Late in the Oestrous Cycle, Upon the Survival and Regression of the Corpus Luteum of the Guinea-Pig

Effects of clomiphene citrate on early pregnancy in guinea-pigs

Physiology and pharmacology of female reproduction under the aspect of fertility control

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