“…The novel concept relies on many illustrations (Spanel-Borowski, 2011a) and is here heightened in details. Different fine-tuning of immunoresponses could explain why, in the hamster ovary, CLs completely disappear within one ovarian cycle (Spanel-Borowski and Heiss, 1986;Gaytán et al, 2001b), whereas regressing stages are seen for several cycles in ovaries of rats, cows and human. Luteal cysts and the persistence of a CL, which leads to a prolonged ovarian cycle, might be explained by immunemediated failure.…”