Luteolin mitigates tamoxifen-associated fatty liver and cognitive impairment in rats by modulating beta-catenin

El-Asfar, Rana K.; El-Derany, Marwa O.; Sallam, Al-Aliaa M.; Wahdan, Sara A.; El‐Demerdash, Ebtehal; Sayed, Sayed A.; El‐Mesallamy, Hala O.

doi:10.1016/j.ejphar.2021.174337

Cited by 12 publications

(7 citation statements)

References 33 publications

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“…In particular, pHPEA-EDA was shown to be able to selectively block cyclooxygenases [ 31 ], demonstrating that, together with inflammatory transcription factors, kinases and cytokines are also present in antimutagenic and anticancer downstream pathways of gallic, caffeic and coumaric acids, verbascoside and pinoresinol [ 32 , 33 , 34 , 35 , 36 ]. Using cell models, the anticancer activities of apigenin and luteolin have been linked to the microRNA-dependent downregulation of E2F1/3 transcription factors [ 37 ], and the use of rats confirmed luteolin’s properties in limiting the adverse effects of antitumorals [ 38 , 39 ]. Free radical scavenging or pro-apoptotic properties and ferulic, vanillic, syringic and 3,4-dihydroxybenzoic acids were demonstrated by in vitro studies [ 29 , 40 ], while animal models showed that restoration properties (e.g., on gut microbiota or asthma) by these molecules involved the modulation of several inflammation parameters and pro-inflammatory cytokines [ 41 , 42 , 43 ].…”

Section: Origin and Functions Of Phenolic Compoundsmentioning

confidence: 99%

A Review of the Effects of Olive Oil-Cooking on Phenolic Compounds

2022

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The fate of phenolic compounds in oil and food during cooking vary according to the type of cooking. From a nutritional point of view, reviews largely suggest a preference for using extra-virgin olive oil at a low temperature for a short time, except for frying and microwaving, for which there appears to be no significant advantages compared to olive oil. However, due to the poorly pertinent use of terminology, the different protocols adopted in studies aimed at the same objective, the different type and quality of oils used in experiments, and the different quality and quantity of PC present in the used oils and in the studied vegetables, the evidence available is mainly contradictory. This review tries to reanalyse the main experimental reports on the fate, accessibility and bioavailability of phenolic compounds in cooking oils and cooked vegetables, by considering different cooking techniques and types of oil and foods, and distinguishing experimental findings obtained using oil alone from those in combination with vegetables. The re-analysis indicates that incomplete and contradictory observations have been published in the last few years and suggests that further research is necessary to clarify the impact of cooking techniques on the phenolic compounds in oil and vegetables during cooking, especially when considering their nutritional properties.

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Section: Origin and Functions Of Phenolic Compoundsmentioning

confidence: 99%

A Review of the Effects of Olive Oil-Cooking on Phenolic Compounds

2022

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“…El‐Asfar et al reported that LUT co‐treatment with TAM significantly enhanced spatial learning and memory impairment and reduced cortex and hippocampal neuronal degeneration. LUT also decreased hepatotoxicity resulting from exposure to TAM in experimental models which was expressed by diminishing levels of serum triacylglycerol (TAG), AST, and ALT 88 . LUT has also been reported to reduce inflammatory factors, such as IL‐1β, TNF‐α, and hepatic TGF‐β levels which play a major role in the development of fatty livers.…”

Section: Lut Against Drug Toxicitymentioning

confidence: 97%

“…These authors found that LUT reduced hepatic β‐catenin levels resulting from fatty liver progression following TAM exposure. LUT may improve TAM‐induced cognitive impairment and fatty liver and also have a protective effect against neurodegeneration resulting from TAM exposure 88 …”

Section: Lut Against Drug Toxicitymentioning

confidence: 99%

Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway

et al. 2022

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Humans are continuously exposed to environmental, occupational, consumer and household products, food, and pharmaceutical substances. Luteolin, a flavone from the flavonoids family of compounds, is found in different fruits and vegetables. LUT is a strong anti‐inflammatory (via inhibition of NF‐κB, ERK1/2, MAPK, JNK, IL‐6, IL‐8, and TNF‐α) and antioxidant agent (reducing ROS and enhancement of endogenous antioxidants). LUT can chelate transition metal ions responsible for ROS generation and consequently repress lipoxygenase. It has been proven that NF‐κB, as a commom cellular pathway plays a considerable role in the progression of inflammatory process and stimulates the expression of genes encoding inducible pro‐inflammatory enzymes (iNOS and COX‐2) and cytokines including IL‐1β, IL‐6, and TNF‐α. This review summarizes the available literature discussing LUT and its potential protective role against pharmaceuticals‐, metals‐, and environmental compounds‐induced toxicities. Furthermore, the review explains the involved protective mechanisms, especially inhibition of the NF‐κB pathway.

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“…The rats were divided into six groups (12 in each group) as follows: 1) sham operated group (sham); 2) MCAO/R (vehicle) group, rats underwent MCAO/R and were then orally treated with 0.9% sterile saline for 7 days at beginning of reperfusion; 3) luteolin-25 group, rats underwent MCAO/R and were then orally treated with 25 mg/kg/d luteolin (MFCD00017309, Macklin, Shanghai, China) dissolved in 0.9% sterile saline (w/v) for 7 days at beginning of reperfusion [19,20]; 4) luteolin-50 group, rats underwent MCAO/R and were then orally treated with 50 mg/kg/d luteolin dissolved in 0.9% sterile saline (w/v) for 7 days at beginning of reperfusion [19,20]; 5) pioglitazone group, rats underwent MCAO/R and were then orally treated with 10 mg/kg/d PPARγ agonist pioglitazone (HY-13956, MedChemExpress, Shanghai, China) [21] dissolved in 0.9% saline for 7 days at beginning of reperfusion; 6) luteolin-50 + T0070907 group, rats underwent MCAO/R and were then orally treated with 50 mg/kg/d luteolin combined with 10 mg/kg/d PPARγ inhibitor T0070907 (HY-13202, MedChemExpress, Shanghai, China) [21] dissolved in 0.9% saline for 7 days at beginning of reperfusion.…”

Section: Experimental Groupsmentioning

confidence: 99%

“…After washing with 0.9% saline, the brain was frozen at − 20 °C for 10 min. Then, the brain tissue was cut into 6 sections, and soaked in 1% TTC solution (20,190,917, Solarbio, China) at room temperature for 15 min without light. The coronal slices were photographed and analyzed by Image J software (National Institutes of health, USA).…”

Section: 35-triphenyltet-razolium Chloride (Ttc) Stainingmentioning

confidence: 99%

Luteolin alleviates inflammation and autophagy of hippocampus induced by cerebral ischemia/reperfusion by activating PPAR gamma in rats

Pan

Ren³

et al. 2022

BMC Complement Med Ther

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Background Luteolin, a flavonoid compound with anti-inflammatory activity, has been reported to alleviate cerebral ischemia/reperfusion (I/R) injury. However, its potential mechanism remains unclear. Methods The binding activity of luteolin to peroxisome proliferator-activated receptor gamma (PPARγ) was calculated via molecular docking analysis. Rats were subjected to middle cerebral artery occlusion and reperfusion (MCAO/R). After reperfusion, vehicle, 25 mg/kg/d luteolin, 50 mg/kg/d luteolin, 10 mg/kg/d pioglitazone, 50 mg/kg/d luteolin combined with 10 mg/kg/d T0070907 (PPARγ inhibitor) were immediately orally treatment for 7 days. ELISA, TTC staining, H&E staining, immunohistochemistry, immunofluorescence and transmission electron microscope methods were performed to evaluate the inflammation and autophagy in damaged hippocampal region. The PPARγ, light chain 3 (LC3) B-II/LC3B-I and p-nuclear factor-κB (NF-κB) p65 proteins expression levels in damaged hippocampal region were analyzed. Results Luteolin showed good PPARγ activity according to docking score (score = − 8.2). Luteolin treatment downregulated the infarct area and the pro-inflammatory cytokines levels caused by MCAO/R injury. Moreover, luteolin administration ameliorated neuroinflammation and autophagy in damaged hippocampal region. Pioglitazone plays protective roles similar to luteolin. T0070907 concealed the neuroprotective roles of 50 mg/kg/d luteolin. Conclusions Luteolin exerts neuroprotective roles against inflammation and autophagy of hippocampus induced by cerebral I/R by activating PPARγ in rats.

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Luteolin mitigates tamoxifen-associated fatty liver and cognitive impairment in rats by modulating beta-catenin

Cited by 12 publications

References 33 publications

A Review of the Effects of Olive Oil-Cooking on Phenolic Compounds

A Review of the Effects of Olive Oil-Cooking on Phenolic Compounds

Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway

Luteolin alleviates inflammation and autophagy of hippocampus induced by cerebral ischemia/reperfusion by activating PPAR gamma in rats

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