Luteolin attenuates acute lung injury in experimental mouse model of sepsis

Rungsung, Soya; Singh, Thakur Uttam; Rabha, Dipankar Jyoti; Kumar, Tarun; Lingaraju, Madhu Cholenahalli; Parida, Subhashree; Paul, Avishek; Sahoo, Monalisa; Kumar, Dinesh

doi:10.1016/j.cyto.2018.03.042

Cited by 55 publications

(34 citation statements)

References 52 publications

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“…According to the degree of the nodes in the compound-target network, we identified eight compounds as potential active ingredients that might participate in the regulatory processes of LJF in ALI. Obviously, the active ingredients chrysoeriol ( Wei et al, 2019 ), luteolin ( Rungsung et al, 2018 ), kaempferol ( Chen et al, 2012 ; Qian et al, 2019 ), and quercetin ( Wang et al, 2018 ) have well-established roles in lung inflammation. ALI-related genes were acquired using the GeneCard database.…”

Section: Discussionmentioning

confidence: 99%

An integrated network pharmacology and RNA-Seq approach for exploring the preventive effect of Lonicerae japonicae flos on LPS-induced acute lung injury

Liu

Yin

Feng

et al. 2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance Lonicerae japonicae flos (LJF, the dried flower bud or newly bloomed flower of Lonicera japonica Thunb.), a typical herbal medicine, targets the lung, heart and stomach meridian with the function of clearing heat and detoxication. It ameliorated inflammatory responses and protected against acute lung inflammation in animal models. Acute lung injury (ALI) is a kind of inflammatory disease in which alveolar cells are damaged. However, a network pharmacology study to thoroughly investigate the mechanisms preventing ALI has not been performed. Aim of the study In this study, we examined the main active ingredients in LJF and the protective effects of LJF on LPS-induced ALI in rats. Materials and methods First, the main active ingredients of LJF were screened in the TCMSP database, and the ALI-associated targets were collected from the GeneCards database. Then, we used compound-target and target-pathway networks to uncover the preventive mechanisms of LJF. Furthermore, we assessed the preventive effects of LJF in an LPS-induced rat model with the RNA-Seq technique to validate the possible molecular mechanisms of the effects of LJF in the treatment of ALI. Results The network pharmacology results identified 28 main active compounds in LJF, and eight chemical components highly related to the potential targets, which were potential active compounds in LJF. In all, 94 potential targets were recognized, including IL6, TNF, PTGS2, APP, F2, and GRM5. The pathways revealed that the possible targets of LJF involved in the regulation of the IL-17 signalling pathway. Then, in vivo experiments indicated that LJF decreased the levels of proinflammatory cytokines (TNF-, IL-1, and IL-6) in serum and bronchoalveolar lavage fluid, decreased the levels of oxidative stress factors (MDA and MPO) and increased the activities of SOD and GSH-Px in lung tissue. The RNA-Seq results revealed that 7811, 775 and 3654 differentially expressed genes (DEGs) in Ctrl (control group), ALI-LJF (Lonicerae japonicae flos group) and ALI-DXSM (dexamethasone group), respectively. KEGG pathway analysis showed that the DEGs associated with immune response and inflammation signalling pathways and the IL-17 signalling pathway were significantly enriched in LJF. Compared with those in ALI, the expression of CXCL2, CXCL1, CXCL6, NFKBIA, IFNG, IL6, IL17A, IL17F, IL17C, MMP9 and TNFAIP3, which are involved in the IL-17 signalling pathway, were significantly decreased in the LJF group according to the qRT-PCR analyses. Conclusions In view of the network pharmacology and RNA-Seq results, the study identified the main active ingredient and potential targets of LJF involved in protecting against ALI, which suggests directions for further research on LJF.

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Section: Discussionmentioning

confidence: 99%

An integrated network pharmacology and RNA-Seq approach for exploring the preventive effect of Lonicerae japonicae flos on LPS-induced acute lung injury

Liu

Yin

Feng

et al. 2021

Journal of Ethnopharmacology

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“… [16] Another experiment confirmed that quercetin could enhance ligand-induced senescent idiopathic pulmonary fibrosis fibroblast apoptosis and reduce lung fibrosis in vivo. [17] Luteolin has been proved to improve experimental pulmonary fibrosis in vivo and in vitro [18] and attenuate acute lung injury in experimental mouse models [ 19 , 20 ]. Isorhamnetin protects mice from acute lung injury by suppressing inflammation, [21] and prevents bleomycin-induced pulmonary fibrosis by inhibiting endoplasmic reticulum stress and epithelial-mesenchymal transformation.…”

Section: Discussionmentioning

confidence: 99%

In silico screening of potential anti–COVID-19 bioactive natural constituents from food sources by molecular docking

Gao

Liang³

et al. 2021

Nutrition

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Highlights Screen potential anti-COVID-19 bioactive natural ingredients from food sources through high-throughput molecular docking. Quercetin, Luteolin and Isorhamnetin as antiviral active phytocompounds Red wine, Chinese hawthorn and blackberry are rich dietary sources of polyphenols with reported health benefits, and they are recommended as preventive supplements

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“…Data show that luteolin (50 μ g/mL) increases the levels of GSH, the expression of GSH synthetase, and the activity of SOD and CAT in human colon cancer cells (HT-29) [ 75 ]. Furthermore, luteolin attenuates the sepsis-induced acute lung injury in mice by reducing lipid peroxidation and increasing SOD and CAT activity, in addition to suppressing the NF- κ B pathway [ 76 ].…”

Section: Occurrence and Antioxidant Properties Of Anticoronavirus mentioning

confidence: 99%

Natural Antioxidants: A Review of Studies on Human and Animal Coronavirus

Diniz¹,

Filho

Fielding

et al. 2020

Oxidative Medicine and Cellular Longevity

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The outbreaks of viruses with wide spread and mortality in the world population have motivated the research for new therapeutic approaches. There are several viruses that cause a biochemical imbalance in the infected cell resulting in oxidative stress. These effects may be associated with the development of pathologies and worsening of symptoms. Therefore, this review is aimed at discussing natural compounds with both antioxidant and antiviral activities, specifically against coronavirus infection, in an attempt to contribute to global researches for discovering effective therapeutic agents in the treatment of coronavirus infection and its severe clinical complications. The contribution of the possible action of these compounds on metabolic modulation associated with antiviral properties, in addition to other mechanisms of action, is presented.

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Luteolin attenuates acute lung injury in experimental mouse model of sepsis

Cited by 55 publications

References 52 publications

An integrated network pharmacology and RNA-Seq approach for exploring the preventive effect of Lonicerae japonicae flos on LPS-induced acute lung injury

An integrated network pharmacology and RNA-Seq approach for exploring the preventive effect of Lonicerae japonicae flos on LPS-induced acute lung injury

In silico screening of potential anti–COVID-19 bioactive natural constituents from food sources by molecular docking

Natural Antioxidants: A Review of Studies on Human and Animal Coronavirus

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