Luteolin and apigenin derived glycosides from Alphonsea elliptica abrogate LPS-induced inflammatory responses in human plasma

Attiq, Ali; Jalil, Juriyati; Husain, Khairana; Mohamad, Hazni Falina; Ahmad, Abrar

doi:10.1016/j.jep.2021.114120

Cited by 27 publications

(17 citation statements)

References 60 publications

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“…The carbon signals attributed to the hexose sugar appeared between δ C 62.8 to δ C 80.1. Compound 4 was identified as isovitexin, and the observed data was consistent with literature values [36,37] …”

Section: Resultssupporting

confidence: 87%

“…The molecular formula was determined as C 21 identified as isovitexin, and the observed data was consistent with literature values. [36,37] Compound 5 was isolated as a white powder. The molecular formula was indicated to be C 7 H 14 O 6 by its positive HR-ESI-MS with m/z 217.0678 [M + Na] + (calculated for C 7 H 14 O 6 Na, 217.0688 [M + Na] + ).…”

Section: Introductionmentioning

confidence: 99%

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Antifungal Compounds from the Leaves of Rhynchosia minima

Adewole

Famuyide

McGaw

et al. 2022

Chemistry & Biodiversity

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Rhynchosia minima, commonly known as jumby bean, is used as a remedy for respiratory ailments in various parts of the world. It is also used by South African traditional healers to treat heart or chest pain. This study aimed to investigate the bioactive constituents of the leaf extracts of R. minima against selected fungal isolates that have been identified as risk factors in respiratory illness. Rhynchosia minima leaves were extracted sequentially using hexane, dichloromethane, ethyl acetate and methanol in increasing order of polarity. The extracts were subjected to repeated chromatographic techniques, for phytochemical isolation. The extracts and isolated compounds were screened against Candida albicans and Cryptococcus neoformans by determining the minimum concentration that inhibited fungal growth. Six flavonoids, one norisoprenoid and one cyclitol were isolated and characterized by 1D and 2D NMR and HR‐ESI‐MS. The extracts obtained in the study had moderate to weak antifungal activities, with MICs ranging from 312.5 to 1250.0 μg/mL against both fungi. Four isolated compounds were also screened, with two of them exhibiting activity against C. albicans (MIC=6.25 μg/mL) that was comparable to amphotericin B, the positive control. These two compounds also had better antifungal potential against C. neoformans with an MIC=6.25 μg/mL, compared to the MIC of 12.5 μg/mL of amphotericin B. Seven of the eight isolated compounds were obtained from the extracts of Rhynchosia minima for the first time. Two of the isolated compounds demonstrated activity comparable or superior to amphotericin B activity. The notable potency displayed by these compounds warrants further investigation on their development as antifungal agents.

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Section: Resultssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Antifungal Compounds from the Leaves of Rhynchosia minima

Adewole

Famuyide

McGaw

et al. 2022

Chemistry & Biodiversity

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“…Park et al found that luteolin administration significantly ameliorated the increased TNF- α production and COX-2 expression in GalN/LPS-induced hepatitic ICR mice [ 18 ]. Attiq et al reported Lu abrogates the LPS-induced inflammatory responses in human plasma, especially decreased the expression of IL-1 β and IL-6 [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Protective Effect of Luteolin on D‐Galactosamine (D‐Gal)/Lipopolysaccharide (LPS) Induced Hepatic Injury by in Mice

Yang

2021

BioMed Research International

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To observe the effects of luteolin on galactosamine (D-Gal)/lipopolysaccharide (LPS) induced liver injury in mice. Male C57BL/6 mice were randomly divided into 4 groups: normal control group, D-GaI/LPS group, D-GaI/LPS + luteolin (Lu, 20 mg/kg), and D-GaI/LPS + luteolin (Lu, 40 mg/kg). Mice in the normal control group and D-GaI/LPS group were given distilled water while other groups were given drugs in 7 days by gavage. 4 hours after the continuous administration, Gal (700 mg/kg) and LPS (10 mg/kg) were injected intraperitoneally. Mice in the normal control group were given the same volume of vegetable oil solution. 24 h after the establishment of the mice model, blood and liver samples were collected. Hematoxylin (HE) staining was used to observe the changes of hepatic histopathology. Alanine aminotransferase (ALT) and glutamic oxalacetic transaminase (AST) in serum, interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor (TNF-α) were measured by related kits. Western blotting was used to demonstrate the expression levels of related inflammation proteins. Lu significantly reduced levels of proinflammatory cytokines including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in serum and liver. Lu restored the pathological changes after galactosamine (D-Gal)/lipopolysaccharide (LPS) treatment. In addition, Lu regulated proteins levels of the NLRP3/NF-κB pathway in liver. Lu exhibited therapeutical effects on D-GaI/LPS induced liver injury in mice which might be related to the regulation of the NLRP3/NF-κB pathway.

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“…This effect may be partly due to downregulation of the oxidized low-density lipoprotein receptor CD36 [ 82 ]. Orientin and isoorientin were found to produce strong inhibition (≥70%), while isovitexin and vitexin moderate inhibition (50–69%) on IL-1β, IL-6, COX-2, and PGE2 expression/activities at 25 and 50 μM concentrations [ 83 ].…”

Section: Effects Of Individual Phytochemical Components Of ...mentioning

confidence: 99%

Anti-Inflammatory Effects of Phytochemical Components of Clinacanthus nutans

et al. 2022

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Recent studies on the ethnomedicinal use of Clinacanthus nutans suggest promising anti-inflammatory, anti-tumorigenic, and antiviral properties for this plant. Extraction of the leaves with polar and nonpolar solvents has yielded many C-glycosyl flavones, including schaftoside, isoorientin, orientin, isovitexin, and vitexin. Aside from studies with different extracts, there is increasing interest to understand the properties of these components, especially regarding their ability to exert anti-inflammatory effects on cells and tissues. A major focus for this review is to obtain information on the effects of C. nutans extracts and its phytochemical components on inflammatory signaling pathways in the peripheral and central nervous system. Particular emphasis is placed on their role to target the Toll-like receptor 4 (TLR4)-NF-kB pathway and pro-inflammatory cytokines, the antioxidant defense pathway involving nuclear factor erythroid-2-related factor 2 (NRF2) and heme oxygenase 1 (HO-1); and the phospholipase A2 (PLA2) pathway linking to cyclooxygenase-2 (COX-2) and production of eicosanoids. The ability to provide a better understanding of the molecular targets and mechanism of action of C. nutans extracts and their phytochemical components should encourage future studies to develop new therapeutic strategies for better use of this herb to combat inflammatory diseases.

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Luteolin and apigenin derived glycosides from Alphonsea elliptica abrogate LPS-induced inflammatory responses in human plasma

Cited by 27 publications

References 60 publications

Antifungal Compounds from the Leaves of Rhynchosia minima

Antifungal Compounds from the Leaves of Rhynchosia minima

[Retracted] Protective Effect of Luteolin on D‐Galactosamine (D‐Gal)/Lipopolysaccharide (LPS) Induced Hepatic Injury by in Mice

Anti-Inflammatory Effects of Phytochemical Components of Clinacanthus nutans

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