Luteolin ameliorates dextran sulfate sodium-induced colitis in mice possibly through activation of the Nrf2 signaling pathway

Li, Yue; Shen, Lei; Luo, Hesheng

doi:10.1016/j.intimp.2016.08.020

Cited by 76 publications

(52 citation statements)

References 37 publications

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“…In addition, luteolin treatment prevented the loss of catalase activity, which is responsible for the conversion of H 2 O 2 into H 2 O and O 2 (Kwiecien et al, ), preserving values similar to those found in the naive group. Li et al () have evaluated the effect of luteolin on DSS‐induced colitis and have found comparable results, suggesting that luteolin may activate the Nrf2 pathway. Nevertheless, luteolin itself is a potent antioxidant molecule (IC 50 of ~1.84 μg·ml −1 was found in DPPH assay; Figure S7), and then, its directly scavenging properties on ROS formed during the pathophysiology of mucositis, at least in part, may contribute for the beneficial effects of the compound, as described here.…”

Section: Discussionmentioning

confidence: 90%

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Boeing

Souza

Speca

et al. 2020

British J Pharmacology

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Background and Purpose: Intestinal mucositis refers to mucosal damage caused by cancer treatment, and irinotecan is one of the agents most associated with this condition. Focusing on the development of alternatives to prevent this important adverse effect, we evaluated the activity of the flavonoid luteolin, which has never been tested for this purpose despite its biological potential. Experimental Approach: The effects of luteolin were examined on irinotecaninduced intestinal mucositis in mice. Clinical signs were evaluated. Moreover, histological, oxidative, and inflammatory parameters were analysed, as well as the possible interference of luteolin in the anti-tumour activity of irinotecan. Key Results: Luteolin (30 mgÁkg −1 ; p.o. or i.p.) prevented irinotecan-induced intestinal damage by reducing weight loss and diarrhoea score and attenuating the shortening of the duodenum and colon. Histological analysis confirmed that luteolin (p.o.)prevented villous shortening, vacuolization, and apoptosis of cells and preserved mucin production in the duodenum and colon. Moreover, luteolin treatment mitigated irinotecan-induced oxidative stress, by reducing the levels of ROS and LOOH and augmenting endogenous antioxidants, and inflammation by decreasing MPO enzymic activity, TNF, IL-1β, and IL-6 levels and increasing IL-4 and IL-10. Disruption of the tight junctions ZO-1 and occludin was also prevented by luteolin treatment.Importantly, luteolin did not interfere with the anti-tumour activity of irinotecan. Conclusion and Implications: Luteolin prevents intestinal mucositis induced byirinotecan and therefore could be a potential adjunct in anti-tumour therapy to control this adverse effect, increasing treatment adherence and consequently the chances of cancer remission.

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Section: Discussionmentioning

confidence: 90%

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Boeing

Souza

Speca

et al. 2020

British J Pharmacology

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“…Li et al . reported the ameliorative effect of Luteolin in dextran sulfate sodium‐induced colitis via activation of the Nrf2 signaling pathway. Similarly, Javkhedkar and Banday documented that Resveratrol activated phase II antioxidant enzymes via Nrf2 signaling cascade, mitigated oxidative stress and normalized high blood pressure in spontaneously hypertensive rats (SHR).…”

Section: Discussionmentioning

confidence: 99%

Luteolin‐mediated Kim‐1/NF‐kB/Nrf2 signaling pathways protects sodium fluoride‐induced hypertension and cardiovascular complications

et al. 2018

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The use of sodium fluoride (NaF) as a major ingredient for tooth paste, mouth wash, and mouth rinse has become inevitable in our day-to-day life. However, flavonoids such as Luteolin might be of great value in the prevention of toxicity associated with accidental or inevitable ingestion of NaF. In the study, 40 male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Group A was the control group and received normal saline, Group B was exposed to NaF at 300 ppm (300 mg/L) in drinking water daily for a week, Groups C and D were exposed to 300 ppm (300 mg/L) of NaF and coadministered with Luteolin orally daily at a dosage of 100 mg/kg and 200 mg/kg for the same time point. Our results indicated that NaF caused significant increases in systolic blood pressure, diastolic blood pressure, mean arterial pressure, malondialdehyde, protein carbonyl, myeloperoxidase, advanced oxidative protein products, together with significant reductions in glutathione peroxidase, superoxide dismutase, catalase, glutathione reductase, reduced glutathione, and nitric oxide (NO) bioavailability. The electrocardiogram results showed that NaF alone caused significant prolongation of QT and QTc intervals. Immunohistochemistry revealed that NaF caused increase expressions of Kidney injury marker 1 (Kim-1), nuclear factor 518 BioFactors Research Communication kappa bet (NF-κB), nuclear factor erythroid 2-related factors 2 (Nrf2), and cardiac troponin I (CTnI). Together, Luteolin coadministration with NaF improved NO bioavailability, reduced high blood pressure, markers of oxidative stress, reversed prolongation of QT and QTc intervals, and lowered the expressions of Kim-1, NF-κB, and CTnI. © 2018 BioFactors, 44(6):518-531, 2018

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“…[55] In addition, Luteolin increased the activity of SOD, CAT and the level of Nrf2 and its downstream targets HO-1 and NQO1 in 3 % dextran sulfate sodium (DSS)-treat rats. [56] Besides, Luteolin increased the level of Nrf2 through Nrf2/NF-κB/P53 signaling pathway in the presence of HgCl 2 which led to increased Bax and decreased Bcl-2. [57] Furthermore, Luteolin inhibits HgCl 2 -induced renal injury by activating Nrf2 signaling pathway and increasing its subsequent protein HO-1, NQO1.…”

Section: Flavonementioning

confidence: 97%

“…Luteolin (1.2 mg/kg body weight/d) could significantly reduce the enzyme activity in colon and liver and increase the level of phase 2 enzyme in Male Balb/C mice . In addition, Luteolin increased the activity of SOD, CAT and the level of Nrf2 and its downstream targets HO‐1 and NQO1 in 3 % dextran sulfate sodium (DSS)‐treat rats . Besides, Luteolin increased the level of Nrf2 through Nrf2/NF‐ κ B/P53 signaling pathway in the presence of HgCl 2 which led to increased Bax and decreased Bcl‐2 .…”

Section: Natural Polyphenols Nrf2 Activators In Multiple Disease Modelsmentioning

confidence: 99%

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Zhou

Jiang

et al. 2019

Chemistry & Biodiversity

140

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The Keap1‐Nrf2/ARE signaling pathway is an important defense system against exogenous and endogenous oxidative stress injury. The dysregulation of the signaling pathway is associated with many diseases, such as cancer, diabetes, and respiratory diseases. Over the years, a wide range of natural products has provided sufficient resources for the discovery of potential therapeutic drugs. Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1‐Nrf2 protein–protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway. In fact, with the continuous improvement of natural polyphenols separation and purification technology and further studies on the Keap1‐Nrf2 molecular mechanism, more and more natural polyphenols monomer components of Nrf2 activators have been gradually discovered. In this view, we summarize the research status of natural polyphenols that have been found with apparent Nrf2 activation and their action modes. On the whole, this review may guide the design of novel Keap1‐Nrf2 activator.

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Luteolin ameliorates dextran sulfate sodium-induced colitis in mice possibly through activation of the Nrf2 signaling pathway

Cited by 76 publications

References 37 publications

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Luteolin‐mediated Kim‐1/NF‐kB/Nrf2 signaling pathways protects sodium fluoride‐induced hypertension and cardiovascular complications

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

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