Luteolin: A Dietary Molecule as Potential Anti-COVID-19 Agent

Ansari, Waseem Ahmad; Ahamad, Tanveer; Khan, Mohsin Ali; Khan, Zaw Ali; Khan, Mohammad Faheem

doi:10.21203/rs.3.rs-35368/v1

Cited by 10 publications

(11 citation statements)

References 16 publications

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“…While some other molecules need further investigation for their potential to control coronavirus infection. For example, luteolin is a flavonoid present in several edible plants; it is also proposed to have ability to manage COVID-19 and need detailed clinical investigations [ 28 ]. In addition, natural compound baicalein is also found to inhibit SARS-CoV-2 protease during in vitro study and draw special attention for development of antivirals against SARS-CoV-2 [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification

Khan

Khan²

2020

Briefings in Bioinformatics

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Last two decades have witnessed several global infectious outbreaks. Among these, coronavirus is identified as a prime culprit ranging from its involvement in severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) to COVID-19. These infections involved in huge healthcare and economic cost incurred globally. Every time, coronavirus improved its infection ability and surprised the medical practitioners and researchers. Currently, COVID-19 is also causing numerous infections and stalled global activities. Global efforts are underway to identify potential viral targets for management of these outbreaks, but significant progress in prevention of these outbreaks is not yet achieved. We explored host–pathogen protein–protein interactions of MERS, SARS and COVID-19, and identified host targets common among all recent coronavirus outbreaks. Further, we tried to understand their potential for management of coronavirus. The common proteins involved in coronavirus host–pathogen interactions indicate their indispensable role in the pathogenesis and therefore targeting these proteins can give strategies to prevent current and future coronavirus outbreaks. Viral variability necessitates development of new therapeutic modalities for every outbreak, in contrast targeting necessary human proteins required by all coronaviruses can provide us a clue to prevent current and future coronavirus outbreaks. We found that targeting FURIN and TMPRSS2 can provide good results due to their common involvement in current and previous outbreaks. We also listed some known molecules against these two targets for their potential drug repurposing evaluation. Although, several recent studies undergoing with targeting these proteins for management of coronavirus, but safety evaluation and risk assessment must be given prime importance while targeting human proteins.

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Section: Discussionmentioning

confidence: 99%

Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification

Khan

Khan²

2020

Briefings in Bioinformatics

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“…Above all, it was found to be the most potent compound among 400 natural compounds against enterovirus-71 and coxsackievirus A 16 infections, since it disrupts viral RNA replication [ 119 ]. Luteolin has antiviral, anti-inflammatory, neurotrophic actions, anti-oxidant, anti-cancer, and anti-apoptotic activities [ 120 ]. It has shown the ability to inhibit the entry of SARS-CoV virus and fusion with human receptors, thus may have potential anti-SARS-CoV-2 activity [ 120 ].…”

Section: Plant-specific Compounds and Antiviral Mechanismsmentioning

confidence: 99%

“…Luteolin has antiviral, anti-inflammatory, neurotrophic actions, anti-oxidant, anti-cancer, and anti-apoptotic activities [ 120 ]. It has shown the ability to inhibit the entry of SARS-CoV virus and fusion with human receptors, thus may have potential anti-SARS-CoV-2 activity [ 120 ].…”

Section: Plant-specific Compounds and Antiviral Mechanismsmentioning

confidence: 99%

Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2

et al. 2021

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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus-2 (SARS-CoV-2), is the most important health issue, internationally. With no specific and effective antiviral therapy for COVID-19, new or repurposed antiviral are urgently needed. Phytochemicals pose a ray of hope for human health during this pandemic, and a great deal of research is concentrated on it. Phytochemicals have been used as antiviral agents against several viruses since they could inhibit several viruses via different mechanisms of direct inhibition either at the viral entry point or the replication stages and via immunomodulation potentials. Recent evidence also suggests that some plants and its components have shown promising antiviral properties against SARS-CoV-2. This review summarizes certain phytochemical agents along with their mode of actions and potential antiviral activities against important viral pathogens. A special focus has been given on medicinal plants and their extracts as well as herbs which have shown promising results to combat SARS-CoV-2 infection and can be useful in treating patients with COVID-19 as alternatives for treatment under phytotherapy approaches during this devastating pandemic situation.

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“…Recently, flavonoids have been extensively studied for targeting the spike protein of SARS-CoV-2 to restrict virus access to host cells and for inhibiting the SARS-CoV 3CL protease to decrease viral infectivity. Molecular docking software identified quercetin and luteolin to be the best candidates for COVID-19 inhibitors [ 93 , 94 , 95 , 96 ].…”

Section: Quercetin and Luteolinmentioning

confidence: 99%

Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis

2021

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The outbreak of SARS-CoV-2 has drastically changed our everyday life and the life of scientists from all over the world. In the last year, the scientific community has faced this worldwide threat using any tool available in order to find an effective response. The recent formulation, production, and ongoing administration of vaccines represent a starting point in the battle against SARS-CoV-2, but they cannot be the only aid available. In this regard, the use of drugs capable to mitigate and fight the virus is a crucial aspect of the pharmacological strategy. Among the plethora of approved drugs, a consistent element is a heterocyclic framework inside its skeleton. Heterocycles have played a pivotal role for decades in the pharmaceutical industry due to their high bioactivity derived from anticancer, antiviral, and anti-inflammatory capabilities. In this context, the development of new performing and sustainable synthetic strategies to obtain heterocyclic molecules has become a key focus of scientists. In this review, we present the recent trends in metal-promoted heterocyclization, and we focus our attention on the construction of heterocycles associated with the skeleton of drugs targeting SARS-CoV-2 coronavirus.

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Luteolin: A Dietary Molecule as Potential Anti-COVID-19 Agent

Cited by 10 publications

References 16 publications

Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification

Comparative host–pathogen protein–protein interaction analysis of recent coronavirus outbreaks and important host targets identification

Medicinal Plants, Phytochemicals, and Herbs to Combat Viral Pathogens Including SARS-CoV-2

Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis

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