Luteinizing hormone (LH) levels in male workers exposed to urban stressors

Tomao, Enrico; Tomei, Gianfranco; Rosati, Maria Valeria; Caciari, Tiziana; Danese, D; Gamberale, D; Vacca, Daniele; Palermo, Paola; Anzelmo, Vincenza; Tomei, Francesco

doi:10.1016/j.scitotenv.2009.05.009

Cited by 15 publications

(11 citation statements)

References 65 publications

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“…Other studies carried out on workers exposed to Pb have shown an inverse relation between plasma testosterone levels and Pb concentration in seminal liquid (Alexander et al 1998). Several researches have shown that some compounds of diesel exhaust particles can be dangerous for human health through oestrogenic and anti-androgenic activity and cause a decrease in testosterone and an increase in plasma LH and FSH levels (Li et al 2006), as observed also in our previous research on traYc policemen Tomao et al 2009). …”

Section: Discussionsupporting

confidence: 78%

“…Previous research of our group, in traYc policemen exposed to urban pollutants, showed changes in mean testosterone plasma levels in female subjects (Tomei et al 2008) and alteration in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) plasma values in male subjects compared to a control group Tomao et al 2009). …”

Section: Introductionmentioning

confidence: 80%

“…According to the literary mentioned research and our recent research on other hormones related to testosterone Tomao et al 2009) evaluated on the same working population, free testosterone plasma levels could be used as an early biological marker, to be employed in occupational sets, valuable for the group, even before the onset of values out of range and fertility disorders. However, we interpret our results with caution and conservative tone, underlining that the results obtained must be conWrmed by further research, that the present study, being a cross-sectional design, is unable to establish causality and is susceptible to reverse causality, also because our research did not include speciWc semen test.…”

Section: Discussionmentioning

confidence: 99%

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Exposure to urban stressors and free testosterone plasma values

Sancini

Tomei

et al. 2010

Int Arch Occup Environ Health

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Exposure to urban stressors and free testosterone plasma values

Sancini

Tomei

et al. 2010

Int Arch Occup Environ Health

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“…In fact, an increasing number of studies suggest that chemicals and pollutants in the environment, such as those arising from the traffic which are caused and spread by human activities, can affect the male reproductive system [106,107,108,109,110,111,112,113,114,115,116] and act as an endocrine disruptor because of their adverse effects on reproduction [117,118] and disruption of steroidogenesis and spermatogenesis [119,120]. Nickel pollution, taken as water-soluble, sulfidic, oxidic or metallic form, is known to modify the function of proteins in mammalian testes in terms of fertility and/or hormone production [119].…”

Section: Discussionmentioning

confidence: 99%

Effect of Chronic Cabergoline Treatment and Testosterone Replacement on Metabolism in Male Patients with Prolactinomas

et al. 2015

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Introduction: Hyperprolactinemia and hypogonadism are reportedly associated with an impaired metabolic profile. The current study aimed at investigating the effects of testosterone replacement and cabergoline (CAB) treatment on the metabolic profile in male hyperprolactinemic patients. Patients and Methods: Thirty-two men with prolactinomas, including 22 with total testosterone (TT) <8 nmol/l (HG, 69%) and 10 with TT >8 nmol/l (non-HG, 31%), were entered in the study. In all patients, metabolic parameters were assessed at diagnosis and after 12- and 24-month treatment. Results: Compared to non-HG patients, at baseline the HG patients had higher waist circumference (WC). TT significantly correlated with body mass index (BMI). Twelve-month CAB induced PRL normalization in 84%. HG prevalence significantly decreased (28%) and non-HG prevalence significantly increased (72%). Anthropometric and lipid parameters, fasting insulin (FI), insulin sensitivity index (ISI₀), homeostatic model assessment of insulin secretion (HOMA-β) and homeostatic model assessment of insulin resistance (HOMA-IR) significantly improved compared to baseline. TT was the best predictor for FI. Percent change (Δ) of TT significantly correlated with ΔCholesterol, ΔWeight and ΔBMI. Compared to non-HG patients, the HG patients had a higher weight, BMI, WC and HOMA-β. In HG, testosterone replacement was started. After 24 months, PRL normalized in 97%. HG prevalence significantly decreased (6%) and non-HG prevalence significantly increased (94%). Anthropometric and lipid parameters, FI, ISI₀, HOMA-β and HOMA-IR significantly improved compared to baseline, with FI, ISI₀, HOMA-β and HOMA-IR further ameliorating compared to the 12-month evaluation. Compared to non-HG patients, the HG patients still had a higher weight, BMI and WC. Conclusions: In hyperprolactinemic hypogonal men, proper testosterone replacement induces a significant improvement in the metabolic profile, even though the amelioration in the lipid profile might reflect the direct action of CAB.

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“…In the medical field if the cause of stress is not eliminated the reaction to it turns chronic and can become an important pathogenic cofactor and source of various psychic and somatic syndromes including anxiety, insomnia, anorexia, panic attacks, irritability, difficulty concentrating and decision (21)(22)(23), hypertension, tachycardia (24)(25)(26), gastro-intestinal disorders (27,28), immune system reduction (29)(30)(31)(32)(33) and cognitive and emotional diseases (21)(22)(23)(34)(35). The literature has repeatedly shown that exposure to acute and chronic stress is able to alter specific hormonal responses involving, in addition to the autonomic nervous system, the neuroendocrine circuits (36,37), the pituitary axes and the organs related to them (38,39). Among these, in recent literature the role played by stress in gastrointestinal and hepatic inflammation is attracting particular interest.…”

Section: Stress and Stress Related Diseasesmentioning

confidence: 99%

Perceived stress and hepatic parameters

Tomei¹

2016

PER

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Introduction: the aim of the study is to evaluate work-related subjective stress in a group of employees, of both sexes, operating in the healthcare and welfare, through the administration of a questionnaire (HSE "Indicator Tool"), specifically developed and officially validated, and to analyze any possible correlations between stress levels taken from the questionnaire scores and the concentrations of three main hepatic parameters (GOT, GPT, GGT). Materials and methods: we studied a final sample of 232 subjects (143 males and 89 females) operating in the health and welfare sector. For research purposes during the medical examination each subject underwent the HSE indicator tool, a collection of information about relevant clinical and medical history and a venous blood sample for the assay of GOT, GPT and GGT. All questionnaires were analyzed using special software provided by the HSE. The results obtained from the questionnaires were statistically compared with the blood concentrations of hepatic parameters. Results: the dimensions found to be critical, associated with a stressful condition (yellow area) or a highly stressful condition (red area), are: managers support, colleagues support, quality of relationships and changes. The Pearson's correlation showed a statistically significant negative correlation (p <0.05) between the mean values of all the critical dimensions and the concentrations of the hepatic parameters, both on the total sample and after subdivision by gender. These results were confirmed in the multiple linear regression analysis, which indicated that the critical dimensions are the main significant variables contributing to the liver parameters alterations. Discussion: preliminary results indicate that a critical perception of stress at work can be statistically associated with increases in mean concentrations of GOT, GPT and GGT in a working asymptomatic population. These results provide a starting point for future studies on this topic, to a greater definition of the link between stress and liver injury, to confirm the effects on the parameters of liver injury (GOT, GPT, GGT) and to investigate possible correlations with the cholestasis parameters (bilirubin, alkaline phosphatase) and serum albumin.

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Luteinizing hormone (LH) levels in male workers exposed to urban stressors

Cited by 15 publications

References 65 publications

Exposure to urban stressors and free testosterone plasma values

Exposure to urban stressors and free testosterone plasma values

Effect of Chronic Cabergoline Treatment and Testosterone Replacement on Metabolism in Male Patients with Prolactinomas

Perceived stress and hepatic parameters

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