Luteinizing hormone (LH) isoforms in ruminants: Characterization and physiological relevance

Perera-Marín, Gerardo; Murcia, C.; González-Padilla, Everardo

doi:10.1016/j.anireprosci.2007.03.011

Cited by 4 publications

(1 citation statement)

References 104 publications

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“…Proper posttranscriptional processing of the LH molecule (Ciccone & Kaiser 2009) and the resulting polysaccharide moiety is important in conferring biological activity to the LH molecule (Bergendah & Veldhuis 2001). Several studies have shown that changes in the mix of LH isoforms may contribute to differences in the response of the female gonad, but less is known about the response in the Leydig cells of the male gonad (Castro-Fernández et al 2000, Perera-Marín et al 2007, Olivares et al 2009. In a rat model of diet-induced obesity, LH bioactivity was reduced, rendering the male hypogonadal (Olivares et al 2010).…”

Section: Effect Of Prenatal Testosterone Excess On Gonadal Testosteromentioning

confidence: 99%

Pituitary and testis responsiveness of young male sheep exposed to testosterone excess during fetal development

Recabarren¹,

Rojas-García²,

Einspanier³

et al. 2013

Reproduction

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Prenatal exposure to excess testosterone induces reproductive disturbances in both female and male sheep. In females, it alters the hypothalamus-pituitary-ovarian axis. In males, prenatal testosterone excess reduces sperm count and motility. Focusing on males, this study tested whether pituitary LH responsiveness to GNRH is increased in prenatal testosterone-exposed males and whether testicular function is compromised in the testosterone-exposed males. Control males (nZ6) and males born to ewes exposed to twice weekly injections of 30 mg testosterone propionate from days 30 to 90 and of 40 mg testosterone propionate from days 90 to 120 of gestation (nZ6) were studied at 20 and 30 weeks of age. Pituitary and testicular responsiveness was tested by administering a GNRH analog (leuprolide acetate). To complement the analyses, the mRNA expression of LH receptor (LHR) and that of steroidogenic enzymes were determined in testicular tissue. Basal LH and testosterone concentrations were higher in the testosterone-exposed-males. While LH response to the GNRH analog was higher in the testosterone-exposed males than in the control males, testosterone responses did not differ between the treatment groups. The testosterone:LH ratio was higher in the control males than in the testosterone-exposed males of 30 weeks of age, suggestive of reduced Leydig cell sensitivity to LH in the testosterone-exposed males. The expression of LHR mRNA was lower in the testosterone-exposed males, but the mRNA expression of steroidogenic enzymes did not differ between the groups. These findings indicate that prenatal testosterone excess has opposing effects at the pituitary and testicular levels, namely increased pituitary sensitivity to GNRH at the level of pituitary and decreased sensitivity of the testes to LH.

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Section: Effect Of Prenatal Testosterone Excess On Gonadal Testosteromentioning

confidence: 99%

Pituitary and testis responsiveness of young male sheep exposed to testosterone excess during fetal development

Recabarren¹,

Rojas-García²,

Einspanier³

et al. 2013

Reproduction

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show abstract

Development of a reporter gene-based assay for the bioactivity determination of rhLH pharmaceutical products

Tang,

Song,

et al. 2024

Analytical Biochemistry

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Effect of ovine luteinizing hormone (oLH) charge isoforms on VEGF and cAMP production

Montero-Pardo

Díaz

Olivares

et al. 2015

Animal Reproduction Science

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Luteinizing hormone (LH) isoforms in ruminants: Characterization and physiological relevance

Cited by 4 publications

References 104 publications

Pituitary and testis responsiveness of young male sheep exposed to testosterone excess during fetal development

Pituitary and testis responsiveness of young male sheep exposed to testosterone excess during fetal development

Development of a reporter gene-based assay for the bioactivity determination of rhLH pharmaceutical products

Effect of ovine luteinizing hormone (oLH) charge isoforms on VEGF and cAMP production

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