Luteinizing Hormone, Follicle Stimulating Hormone, and Growth Hormone Secretion in Normal Adult Men During Sleep and Dreaming

Rubín, Robert T.; Gouin, Paul R.; Kales, Anthony; Odell, William D.

doi:10.1097/00006842-197307000-00005

Cited by 24 publications

(10 citation statements)

References 43 publications

(50 reference statements)

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“…Kendall's W was nonsignificant for both hormones. These results are consistent with several previous studies of LH and FSH which indicate little or no circadian rhythm for either of these hormones in the adult male (10,19,20,27,28). On the other hand, both PRL and T showed consistently high correlations with the best-fit 24-h sine curve (range for each hormone = +0.40 to +0.92).…”

Section: Resultssupporting

confidence: 92%

“…Eight healthy male volunteers, 20-32 yr of age, not on drugs or medications, were studied for 4 consecutive nights according to an established protocol (19,20). The first 2 nights were for adaptation to the sleep laboratory.…”

Section: Methodsmentioning

confidence: 99%

“…The rhythmicity of hormone secretion was measured by fitting sine curves of circadian and ultradian periodicities to the hormone data, as was done in a previous study of nocturnal patterns of LH and FSH release (19,20). Kendall's rank order coefficient of concordance (W) (25) also was used to compare average hormone values by thirds of the night across the 8 subjects to test for slow trends in hormone levels as the night progressed.…”

Section: Methodsmentioning

confidence: 99%

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Nocturnal Increase of Plasma Testosterone in Men: Relation to Gonadotropins and Prolactin

Rubín

Gouin

Lubin

et al. 1975

The Journal of Clinical Endocrinology & Metabolism

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The nocturnal increase of plasma testosterone (T) in adult men has been well established. Luteinizing hormone (LH) does not show a similar increase throughout the night, whereas prolactin (PRL) does, suggesting the possibility of other hormone influence on T secretion. To investigate this possibility, 8 young adult men were studied for 4 consecutive nights in the sleep laboratory (2 nights adaptation, 2 nights blood sampling), by blood samples taken every 30 min during the 8-h sleep period, for measurement of LH, follicle stimulating hormone (FSH), PRL, and T. LH and FSH were secreted episodically, with little or no change in baseline levels during the night. PRL and T also were secreted episodically, but their baseline levels increased as the night progressed. Both LH and PRL had maximum within-subject correlations (averages equal +0.35 and +0.48 respectively) with T when they led T by 60 min. Within-subject correlations done on first differences (to remove the effect of slow trends) were near zero. LH and PRL had larger correlations with T than did FSH, for both calculations. These data suggest that both LH and PRL levels precede T levels by about 60 min. PRL thus may participate in the regulation of nocturnal T secretion in adult men.

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Section: Resultssupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Nocturnal Increase of Plasma Testosterone in Men: Relation to Gonadotropins and Prolactin

Rubín

Gouin

Lubin

et al. 1975

The Journal of Clinical Endocrinology & Metabolism

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“…There was a pattern of irregularly occurring abrupt rises in LH and testosterone concentrations in normal men, consistent with the results of our earlier work (15,20) and that of other investigators (21)(22)(23)(24). Quantitative characterization of testosterone and LH changes in terms of number of peaks, amount, and percentage of peak hormonal increases based on a mean of 44 determinations per subject did not reveal significant differences between the primary-and secondary-impotent groups and normal controls.…”

Section: Discussionsupporting

confidence: 91%

Pituitary-Gonadal Function During Sleep in Men with Erectile Impotence and Normal Controls

Schiavi

Fisher

White

et al. 1984

Psychosomatic Medicine

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Studies of pituitary-gonadal function in men with erectile disorders have provided conflicting findings. This study compares blood LH and testosterone during sleep in 17 physically healthy men with erectile impotence and 12 matched normal controls, and relates hormonal variations to stages of sleep and penile tumescence. Subjects, aged 23-36 were studied in a sleep laboratory for 3-6 nights with the last two nights devoted to sequential blood sampling every 20 minutes. Five men had never been able to achieve intercourse (primary impotent group) and 12 suffered from a life-long history of intermittent erectile failures (secondary-impotent group). There were no significant differences in sleep duration and REM time among the impotent groups and normal controls. Primary-impotent men showed half as many full tumescent episodes as secondary-impotent men and controls, and spent significantly less time above 80% of full tumescence. The secondary-impotent group did not differ in nocturnal penile tumescent measures from controls. There was a pattern of irregularly occurring fluctuations in plasma LH and testosterone with no differences among groups in frequency and amount of peak hormonal increases. Normal subjects had significantly higher mean testosterone concentrations during REM sleep than during other sleep stages, and during full tumescence than during partial and nontumescent periods. A direct causal relation between REM-related activity and circulating testosterone was not supported by the observation that the hormonal levels during REM sleep and during full tumescence did not differ statistically from the levels measured during adjacent time periods. As with normal subjects, the secondary-impotent group exhibited higher testosterone levels during REM sleep and full tumescence; by contrast, the primary-impotent group did not show significant hormonal differences across stages of sleep and tumescent/ nontumescent periods. These data are discussed with respect to the possible existence of subgroups of impotent men without known organic pathology than may be characterized by psychophysiologic and endocrine differences during sleep.

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“…It has been shown that the concentration of luteinizing hormone (LH), which is generally assumed to be the stimulus to testosterone secretion, is 14% higher in REM sleep than in NREM (8). LH secretory episodes generally commence in NREM sleep and exhibit a 70-90 min periodicity as the NREM-REM cycles do.…”

Section: Introductionmentioning

confidence: 99%

Plasma Testosterone and Sleep: Relationship to Sleep Stage Variables

Roffwarg

Sachar

Halpern

et al. 1982

Psychosomatic Medicine

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A study was performed to determine whether the pattern of secretion of testosterone (T) during the night bears a systematic relationship to the cyclically recurring periods of rapid eye movement (REM) and non-REM (NREM) sleep. In four healthy male volunteers, 10-20 min sampling of plasma for T was carried out through a long indwelling catheter in conjunction with all-night polysmonography. Analysis of plasma T, comparing the samples drawn during the REM and NREM stages, did not reveal a significant difference in the mean concentration of T between the two sleep stages or among specified time segments of the NREM-REM cycles. A more exacting approach to exploring for a correlation of the secretory pattern with the sleep-stage cycle was then undertaken. This method used the NREM-REM cycle as the independent variable in the analysis. We were able to demonstrate that the positions of the peaks and troughs of T concentration in each REM-NREM cycle are discriminable when examined in relation to the time of REM sleep onset in each cycle. The tendency for peaks in T concentration to be associated with repetitive inaugurations of REM sleep is coordinate with a pattern of serial "upswing" in T concentrations that occurs in the period from 30 to 10 min before the transition from NREM to REM sleep. Accordingly, it proved possible to demonstrate certain signs of interaction between the activity of the pituitary-gonadal system and the mechanisms that regulate central nervous system state in sleep. The more traditional parameter of comparison (mean concentration of hormone in REM and NREM sleep) did not detect the association.

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Luteinizing Hormone, Follicle Stimulating Hormone, and Growth Hormone Secretion in Normal Adult Men During Sleep and Dreaming

Cited by 24 publications

References 43 publications

Nocturnal Increase of Plasma Testosterone in Men: Relation to Gonadotropins and Prolactin

Nocturnal Increase of Plasma Testosterone in Men: Relation to Gonadotropins and Prolactin

Pituitary-Gonadal Function During Sleep in Men with Erectile Impotence and Normal Controls

Plasma Testosterone and Sleep: Relationship to Sleep Stage Variables

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