Luteinizing hormone changes in gonadotropin-releasing hormone antagonist protocol in in vitro fertilization cycles: A cross-sectional study

Rashidi, Batool; Kabodmehri, Roya; Shariat, Mamak; Tehraninejad, Ensieh Shahrokh; Abdollahi, Alireza; Bagheri, Maryam; Hagholahi, Fedieh

doi:10.18502/ijrm.v17i3.4520

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…In another study, Hosein Rashidi and colleagues[ 19 ] found a significant relationship between the LH level and M1 oocytes. Despite the fact that the required amount of LH for follicle and oocyte maturation is not recognized,[ 22 ] it has been shown that excessive LH concentration damage follicular development.…”

Section: Discussionmentioning

confidence: 99%

“…The authors concluded that LH changes above or below 50% had no effect on the laboratory and clinical outcome. [ 19 ] On the other hand, Huirne and colleagues compared the fluctuation of the serum LH level in five groups with different dosages of GnRH–antagonist administration with regard to clinical outcome. They concluded that no pregnancies were detected in either very high or low LH levels, which confirms the optimum window hypothesis.…”

Section: Discussionmentioning

confidence: 99%

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Is there a relationship between luteinizing hormone levels and ART outcome in GnRH antagonist protocols? A retrospective cross-sectional study

Tabibnejad¹,

Eftekhar²,

Hoseini³

2021

Indian J Endocr Metab

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Objective: To evaluate the potential link between serum LH concentrations on the day of oocyte triggering and pregnancy outcome during controlled ovarian hyperstimulation. Materials and Methods: In this retrospective cross-sectional study, data of women ≤42 years undergoing fresh embryo transfer cycles and who had downregulated with GnRH antagonist protocol in a 12-month period was reviewed. Patients with incomplete hospital records were excluded. Women were divided into four groups based on the percentiles of the serum LH level on the day of oocyte triggering: <1.49 (<25 th percentile), 1.49–2.59 (25–50 th percentile), 2.60–4.60 (50–75 th percentile), and >4.60 IU/L (>75 th percentile). Clinical pregnancy was considered the primary outcome, while chemical pregnancy and implantation rate were the most important secondary outcomes which were compared between the four groups. Results: Four hundred and nighty-three women of 1003 infertile women, who were initially assessed for eligibility, met the inclusion criteria. Finally, 426 women were analyzed. Levels of progesterone were significantly correlated with the level of LH on the day of trigger in the >4.60 IU/L group ( r = 0.20, P = 0.034). Furthermore, the levels of estradiol were significantly correlated with the level of LH on the day of trigger in the <1.49 IU/L ( r = 0.21, P = 0.026). The number of retrieved oocytes, 2PNs (two pronucleis), number, and quality of total embryos were similar between groups ( P > 0.05). With regard to oocyte maturity rate, fertilization proportion, fertilization rate, chemical pregnancy rate, and clinical pregnancy rate, there was no difference between varied LH levels in the four groups ( P > 0.05). The only observed difference was the implantation rate that was significantly higher in the 2.60–4.60 IU/L group than the <1.49 IU/L group ( P < 0.05). Conclusions: Our result could not show the potential link between LH concentrations during GnRH antagonist cycles and pregnancy outcomes. However, very low LH levels during ovarian stimulation period may negatively affect the implantation rate.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Is there a relationship between luteinizing hormone levels and ART outcome in GnRH antagonist protocols? A retrospective cross-sectional study

Tabibnejad¹,

Eftekhar²,

Hoseini³

2021

Indian J Endocr Metab

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“…Hosein Rashidi et al measured serum LH levels 24 hours before and after the first GnRH-A injection in 70 poor responders and egg donor women or those diagnosed with PCOS. They found that LH changes above or below 50% did not impact clinical outcomes [1] . Moreover, previous studies have investigated the relationship between serum LH levels and oocyte yield, MII, and fertilization rates at 12 hours post-trigger in patients treated with a flexible GnRH-A protocol.…”

Section: Discussionmentioning

confidence: 99%

“…Infertility is a common disease that affects approximately 15% of families worldwide. In recent decades, in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) has enabled millions of infertile couples to achieve conception [1] . An individualized and carefully controlled ovarian hyperstimulation (COH) protocol is critical for successful IVF/ICSI [2] .…”

Section: Introductionmentioning

confidence: 99%

Association between luteinizing hormone level decrease on the triggering day and pregnancy outcome for in vitro fertilization/intracytoplasmic sperm injection patients following gonadotropin-releasing hormone antagonist protocol: a retrospective cohort study

Tang

Wang

et al. 2023

Reproductive and Developmental Medicine

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Objective: Optimal luteinizing hormone (LH) levels for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) patients following the gonadotropin-releasing hormone (GnRH) antagonist protocol remain controversial. This study aimed to estimate the association between serum LH levels on the triggering day (LHLOT) and clinical pregnancy outcomes in IVF/ICSI patients following the GnRH antagonist protocol. Methods: We enrolled 4743 IVF/ICSI cycles using flexible or fixed GnRH antagonist protocols between January 2017 and June 2021. The patients were stratified into four groups according to the LHLOT quartiles (Q1–Q4). Each group was further divided into two subgroups according to the median basal LH/LHLOT. The main outcomes were clinical pregnancy, birth, and miscarriage rates. Secondary outcomes were oocyte yield, number of MII, fertilized oocytes (2PN), and high-quality embryos. Results: Serum LHLOT levels were negatively correlated with oocyte yield and the numbers of MII, 2PN, and high-quality embryos. Reproductive outcomes were compared among the different quartiles and subgroups. The absolute difference in the clinical pregnancy rates between the Q4 and Q1 groups was 6.4% (47.2% vs. 40.8%, P <0.05). Clinical pregnancy rates between the subgroups with basal LH/LHLOT >3.04 and ≤3.04 were 32.7% and 48.6% (P <0.01), respectively, in Q1. Within Q3, the clinical pregnancy rates between the subgroups with basal LH/LHLOT >2.14 and ≤2.14 were 50.2% and 41.9%, respectively (P <0.05). The greater the decrease in LH levels, the lower the oocyte maturation rate across all quartiles. Conclusions: According to the LHLOT quartiles, the Q1 of serum LHLOT <1.43 IU/L may result in a higher number of oocytes but reduced oocyte maturation and lower clinical pregnancy rates. A decrease in LH levels by approximately 2.14 to 3.04 times compared to basal LH levels may lead to higher clinical pregnancy rates in IVF/ICSI patients following the GnRH antagonist protocol.

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The Effect of Age and AMH Level on ART Outcomes in Patients With Reduced Ovarian Reserve: A Retrospective Cross-Sectional Study

Hosseinzadeh

Kabodmehri

Mehrafza

et al. 2022

J Obstet Gynecol India

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Luteinizing hormone changes in gonadotropin-releasing hormone antagonist protocol in in vitro fertilization cycles: A cross-sectional study

Abstract: .

Cited by 3 publications

References 22 publications

Is there a relationship between luteinizing hormone levels and ART outcome in GnRH antagonist protocols? A retrospective cross-sectional study

Is there a relationship between luteinizing hormone levels and ART outcome in GnRH antagonist protocols? A retrospective cross-sectional study

Association between luteinizing hormone level decrease on the triggering day and pregnancy outcome for in vitro fertilization/intracytoplasmic sperm injection patients following gonadotropin-releasing hormone antagonist protocol: a retrospective cohort study

The Effect of Age and AMH Level on ART Outcomes in Patients With Reduced Ovarian Reserve: A Retrospective Cross-Sectional Study

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