Lutein-loaded lipid-core nanocapsules: Physicochemical characterization and stability evaluation

Brum, Aelson Aloir Santana; Santos, Priscilla Pereira dos; Silva, Médelin Marques da; Paese, Karina; Guterres, Sílvia Stanisçuaski; Costa, Tânia Maria Haas; Pohlmann, Adriana Raffin; Jablonski, André; Flôres, Simone Hickmann; Rios, Alessandro de Oliveira

doi:10.1016/j.colsurfa.2017.03.041

Cited by 40 publications

(22 citation statements)

References 46 publications

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“…All the values for carbamazepine EE were higher than 98% (Figure 3), which were in agreement with the similar results for the nanoencapsulation of non-polar drugs in nanocapsules with an oily liquid core [20][21][22]. It has been previously established that nanoprecipitation gives some of the best results for non-polar drug encapsulation (80% or more) [13].…”

Section: Effect On Encapsulation Efficiencysupporting

confidence: 90%

“…From a general perspective, nanocapsules can be defined as the nanovesicular systems that exhibit a typical coreshell structure, where active ingredients, such as a drug can be incorporated or confined inside an oily cavity surrounded by a polymeric or coating membrane [18,19]. Nanocapsules have been demonstrated to have many benefits over the traditional pharmaceutical dosage, such as offering better drug release kinetics [13,20], physicochemical stability [21,22] and drug bioavailability [23][24][25]. Moreover, their subcellular size facilitates absorption of the active pharmaceutical ingredient [26,27].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between the process variables and physicochemical features of liquid-core nanocapsules produced via nanoprecipitation

2019

Biointerface Res Appl Chem

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This study investigates the relationship between the physicochemical features of liquid-core nanocapsules created via nanoprecipitation and the adopted process variables. The process variables evaluated are the amount of coating polymer (poly--caprolactone), the amount of stabilizer polymer (poloxamer-188) and the stirring velocity. A statistical response surface methodology is employed to analyze the effect of the process variables on the physicochemical variables of size, polydispersity, zeta potential and efficiency in encapsulating a non-polar drug (carbamazepine). The results show that, although the process variables do not have a statistically significant effect on the response variables, the amount of coating polymer, the amount of stabilizer, and the stirring rate are physicochemically relevant. It is also found that the nanocapsules can contain more than 98% of the model drug, but the efficiency of the drug released may be affected by the process conditions.

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Section: Effect On Encapsulation Efficiencysupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Relationship between the process variables and physicochemical features of liquid-core nanocapsules produced via nanoprecipitation

2019

Biointerface Res Appl Chem

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“…It has already been demonstrated that nanoencapsulation of lipophilic molecules can increase their concentration in a gel while keeping its pH, rheological or sensory properties unchanged [12,13]. Moreover, nanosystems have also been used to disperse homogeneously an active molecule in films for transdermal or dermal delivery [6,10,[14][15][16][17]. In the present study, a nanodispersion of Punica granatum seed oil hydroxyphenethyl ester (PHE) was prepared by an ultrasound-mediated emulsion-evaporation method.…”

Section: Introductionmentioning

confidence: 96%

Homogeneous distribution of fatty ester‐based active cosmetic ingredients in hydrophilic thin films by means of nanodispersion

Munnier

Assaad

David

et al. 2020

Intern J of Cosmetic Sci

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Objective Cosmetic films and patches are interesting forms to promote skin penetration of active ingredients as they ensure their long stay on the treated zone of the skin. Nevertheless, currently developed films and patches are most of all hydrophilic and are not adapted to the hydrophobic molecules. The aim of this study was to establish whether nanodispersion of fatty acid‐based active cosmetic ingredients (ACI) could be a manner to introduce high concentrations of those ACI in hydrophilic films. Methods Punica granatum seed oil hydroxyphenethyl esters (PHE) constitute a commercialized lipolytic cosmetic ingredient obtained by enzymatic conjugation of tyrosol to long‐chain fatty acids and to enhance its skin diffusion. Nanodispersions of PHE were prepared by a green emulsion‐solvent evaporation process and dispersed in polyvinyl alcohol films. Raman imaging coupled to multivariate analysis was used to study the distribution of PHE in the films. Results Nanodispersions of PHE combined with antioxidant vitamin E and stabilized by Pluronic® F127 were successfully prepared. The nanodispersions show a spherical shape and a hydrodynamic diameter close to 100 nm. Raman images analysis with multivariate approaches showed a very homogeneous distribution of PHE nanodispersions in the films compared to free PHE introduced as an ethanol solution. Conclusion Nanodispersions of hydrophobic fatty acid‐based ingredients seem to be relevant method to introduce this type of ingredient in hydrophilic film matrix. The co‐suspension with vitamin E limits their degradation in time.

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“…Microencapsulation method introduced by Rigon and Noreña 63 can lessen the oxidation of bioactive compounds in foods and allow better powder dispersal in water. Other techniques suggested by Brum et al 64 used to stabilize lutein include nanoemulsion and nanocapsules, where a particle size of smaller than 1 μm can significantly facilitate lutein's solubility, thus improving its bioavailability and stability. The previous study conducted by Boon et al 7 , reported that chitosan nanoparticles can improve lutein's solubility and stability (by 58%) when compared to polyethylene glycol nanocapsules.…”

Section: Severe Traumatic Brain Injury (Stbi)mentioning

confidence: 99%

Lutein: A Comprehensive Review on its Chemical, Biological Activities and Therapeutic Potentials

Fuad¹,

Sekar²,

Gan³

et al. 2020

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To complete this review, relevant literatures were collected from several scientific databases, include Google Scholar, Pubmed and ScienceDirect between 2000 to till date. The categories of keywords used were "Lutein" and "Sources" or "Pharmacological Studies" or "Molecular Mechanism" or "Biological Properties" or "Chemistry" or "Food Industry" or "Food Products" or "Formulations" or "Health Benefits". Studies which are not written in English and have no abstracts have been excluded from initial screening. There was no restriction to be followed for collecting the lutein-related studies, particularly in animal and human studies. After applying the inclusion and exclusion criteria and removing duplicates from the ABSTRACT Background: Lutein is a naturally occurring carotenoid found in high amounts in flowers, grains, fruits and green vegetables with green leaves include spinach, kale and carrots. The market for lutein encompasses pharmaceutical, dietary supplement, food, animal and fish feed industries. Objective: The present review aimed to provide an updated and comprehensive analysis of lutein, including its chemistry, biological properties and therapeutic potentials. Methods: Relevant literatures were collected from several scientific databases, include Google Scholar, Pubmed and ScienceDirect between 2000 to till date. Following a detailed inclusion and exclusion screening process, the information obtained was summarized. Results: Information on the sources, chemistry and biological properties including antioxidant, anti-arthrisits, antiinflammatory, hepatoprotective, cardioprotective, anti-cataract, antidiabetic, anticancer and bone remodelling activities, as well as food industry processing for lutein were tabled. Lutein can be considered powerful antioxidants along with multifaceted molecular targets, such as NF-ҡB, PI3K/Akt, Nrf-2, HO-1 and SIRT-1 signaling pathways in various pathological conditions. Conclusion: The present review observe the chemical, pharmacological properties, in addition to the therapeutic potentials of lutein. It is hoped that the information can provide a good reference to aid in the development and utilization of lutein in phytopharmaceuticals and food industries.

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Lutein-loaded lipid-core nanocapsules: Physicochemical characterization and stability evaluation

Cited by 40 publications

References 46 publications

Relationship between the process variables and physicochemical features of liquid-core nanocapsules produced via nanoprecipitation

Relationship between the process variables and physicochemical features of liquid-core nanocapsules produced via nanoprecipitation

Homogeneous distribution of fatty ester‐based active cosmetic ingredients in hydrophilic thin films by means of nanodispersion

Lutein: A Comprehensive Review on its Chemical, Biological Activities and Therapeutic Potentials

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