Lutein and Zeaxanthin Protect Photoreceptors from Apoptosis Induced by Oxidative Stress: Relation with Docosahexaenoic Acid

Chucair, A. J.; Rotstein, Nora P.; SanGiovanni, John Paul; During, Alexandrine; Chew, Emily Y.; Politi, Luis E.

doi:10.1167/iovs.07-0037

Cited by 153 publications

(113 citation statements)

References 40 publications

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“…Consequently, we propose supplementation for preterm neonates may protect photoreceptors and, thereby, affect retinal development. Mechanisms may involve lutein's light absorbing, antioxidant 39 and/or anti-inflammatory 40 activities. These same pathways appear to have a critical role in preventing ROP development and/or progression.…”

Section: Discussionmentioning

confidence: 99%

Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants

et al. 2011

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Objective: Dietary carotenoids (lutein, lycopene and b-carotene) may be important in preventing or ameliorating prematurity complications. Little is known about carotenoid status or effects of supplementation.Study Design: This randomized controlled multicenter trial compared plasma carotenoid levels among preterm infants (n ¼ 203, <33 weeks gestational age) fed diets with and without added lutein, lycopene and b-carotene with human milk (HM)-fed term infants. We assessed safety and health.Result: Plasma carotenoid levels were higher in the supplemented group at all time points (P<0.0001) and were similar to those of term HM-fed infants. Supplemented infants had lower plasma C-reactive protein (P<0.001). Plasma lutein levels correlated with the full field electroretinogram-saturated response amplitude in rod photoreceptors (r ¼ 0.361, P ¼ 0.05). The supplemented group also showed greater rod photoreceptor sensitivity (least squares means 6.1 vs 4.1; P<0.05). Conclusion:Carotenoid supplementation for preterm infants raises plasma concentrations to those observed in HM-fed term infants. Carotenoid supplementation may decrease inflammation. Our results point to protective effects of lutein on preterm retina health and maturation.

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Section: Discussionmentioning

confidence: 99%

Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants

et al. 2011

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“…141 The protective role of lutein, zeaxanthin, and other antioxidants has also been shown in many other animal studies. 142,143 Owing to the ability of macular pigments to serve as both effective absorbers of high-energy, short-wavelength light, as well as antioxidants, many investigators have started to measure macular pigment optical density. In fact, several groups of investigators have shown an increase in macular pigment density [144][145][146] Additionally, the lutein antioxidant supplementation trial (LAST) and the LUNA study both support the association between dietary supplementation and macular pigment density.…”

Section: Variables In Photochemical Injurymentioning

confidence: 99%

Retinal light toxicity

Youssef

Sheibani

Albert

2010

Eye

271

204

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The ability of light to enact damage on the neurosensory retina and underlying structures has been well understood for hundreds of years. While the eye has adapted several mechanisms to protect itself from such damage, certain exposures to light can still result in temporal or permanent damage. Both clinical observations and laboratory studies have enabled us to understand the various ways by which the eye can protect itself from such damage. Light or electromagnetic radiation can result in damage through photothermal, photomechanical, and photochemical mechanisms. The following review seeks to describe these various processes of injury and many of the variables, which can mitigate these modes of injury.

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“…Xanthophylls act as antioxidants and shield ocular structures from blue light, which causes retinal injury leading to AMD ( 6 , 7 ). Previously, numerous studies showed that lutein has the potential to delay the development of AMD (8)(9)(10)(11)(12)(13). Lutein and zeaxanthin have been described as protecting photoreceptors from apoptosis induced by oxidative stress in vitro ( 8 ).…”

mentioning

confidence: 99%

“…Previously, numerous studies showed that lutein has the potential to delay the development of AMD (8)(9)(10)(11)(12)(13). Lutein and zeaxanthin have been described as protecting photoreceptors from apoptosis induced by oxidative stress in vitro ( 8 ). In an animal study, lutein supplementation led to suppression of choroidal neovascularization development associated with inflammatory processes and subsequent upregulation of inflammation molecules ( 9 ).…”

mentioning

confidence: 99%

Effects of Mayonnaise on Postprandial Serum Lutein/Zeaxanthin and β-Carotene Concentrations in Humans

Takeda

Masuda

Usuda

et al. 2009

J Nutr Sci Vitaminol

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Summary To clarify the effects of different physical forms of oil on postprandial serum lutein/zeaxanthin and ␤ -carotene concentrations, we performed a vegetable meal loading test. Eighteen healthy subjects participated in the test, which consisted of broccoli as a control (CON) meal, broccoli with oil (OIL), and broccoli with mayonnaise (MS), consumed in random order. After collection of fasting blood samples, subjects consumed one of the three test meals. Fasting and postprandial changes in serum carotenoids were assessed 2, 4, and 6 h after ingestion of each test meal. Serum lutein/zeaxanthin and ␤ -carotene concentrations were measured. Although no significant change was noted after the CON meal, the serum lutein/zeaxanthin concentration was higher at 4 h after consumption of the OIL meal, and at 2, 4 and 6 h after consumption of the MS meal, as compared with the fasting state. Serum ␤ -carotene concentrations did not change after ingestion of either the CON or the OIL meal but were elevated 2, 4, and 6 h after MS ingestion as compared with the fasting state. The incremental areas under the curves (IAUCs) of serum lutein/zeaxanthin and ␤ -carotene concentrations were higher after the MS meal than after the CON meal. IAUCs after the OIL meal exhibited no statistically significant differences from the CON and MS meals. We suggest that mayonnaise contributes to increase serum lutein/zeaxanthin and ␤ -carotene concentrations when consumed with vegetables rich in these carotenoids.

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Lutein and Zeaxanthin Protect Photoreceptors from Apoptosis Induced by Oxidative Stress: Relation with Docosahexaenoic Acid

Abstract: These results show for the first time the direct neuroprotection of photoreceptors by xanthophylls and suggest that ZEA and LUT, along with DHA, are important environmental influences that together promote photoreceptor survival and differentiation.

Cited by 153 publications

References 40 publications

Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants

Effect of carotenoid supplementation on plasma carotenoids, inflammation and visual development in preterm infants

Retinal light toxicity

Effects of Mayonnaise on Postprandial Serum Lutein/Zeaxanthin and β-Carotene Concentrations in Humans

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