Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration’s evidence-based review system for health claims

Trumbo, Paula R.; Ellwood, Kathleen C.

doi:10.1093/ajcn/84.5.971

Cited by 88 publications

(41 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 2006, the Food and Drug Administration concluded that there was no credible evidence to support a health claim for lutein or zeaxanthin intake in relation to the risk of AMD ( 14 ). However, the National Eye Institute started a new randomized clinical trial called the Age-Related Eye Disease Study 2, designed to evaluate the effects of nutrients including lutein on the development of AMD ( 15 ).…”

mentioning

confidence: 99%

Effects of Mayonnaise on Postprandial Serum Lutein/Zeaxanthin and β-Carotene Concentrations in Humans

Takeda

Masuda

Usuda

et al. 2009

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

Summary To clarify the effects of different physical forms of oil on postprandial serum lutein/zeaxanthin and ␤ -carotene concentrations, we performed a vegetable meal loading test. Eighteen healthy subjects participated in the test, which consisted of broccoli as a control (CON) meal, broccoli with oil (OIL), and broccoli with mayonnaise (MS), consumed in random order. After collection of fasting blood samples, subjects consumed one of the three test meals. Fasting and postprandial changes in serum carotenoids were assessed 2, 4, and 6 h after ingestion of each test meal. Serum lutein/zeaxanthin and ␤ -carotene concentrations were measured. Although no significant change was noted after the CON meal, the serum lutein/zeaxanthin concentration was higher at 4 h after consumption of the OIL meal, and at 2, 4 and 6 h after consumption of the MS meal, as compared with the fasting state. Serum ␤ -carotene concentrations did not change after ingestion of either the CON or the OIL meal but were elevated 2, 4, and 6 h after MS ingestion as compared with the fasting state. The incremental areas under the curves (IAUCs) of serum lutein/zeaxanthin and ␤ -carotene concentrations were higher after the MS meal than after the CON meal. IAUCs after the OIL meal exhibited no statistically significant differences from the CON and MS meals. We suggest that mayonnaise contributes to increase serum lutein/zeaxanthin and ␤ -carotene concentrations when consumed with vegetables rich in these carotenoids.

show abstract

mentioning

confidence: 99%

Effects of Mayonnaise on Postprandial Serum Lutein/Zeaxanthin and β-Carotene Concentrations in Humans

Takeda

Masuda

Usuda

et al. 2009

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

show abstract

“…The US Food and Drug Administration (FDA) has conducted an evidence-based review to evaluate the role of lutein and zeaxanthin in reducing the risk of AMD 62 . After reviewing a number of intervention and observational studies, the FDA denied a health claim about the intake of lutein or zeaxanthin (or both) and the risk of AMD in 2006.…”

Section: Carotenoids (β-Carotene Lutein and Zeaxanthin)mentioning

confidence: 99%

Nutritional Supplement Use and Age-Related Macular Degeneration

Lo¹,

Wong²

2012

View full text Add to dashboard Cite

“…Entretanto, seus efeitos benéficos na degeneração macular permanecem controversos. O Food and Drug Administration (FDA) conduziu uma revisão de estudos para averiguar e ter a certeza sobre as evidências científicas do papel da luteína e zeaxantina na degeneração macular e cataratas (40) . Com base nas revisões, o FDA concluiu que não existem evidências fidedignas sobre a atuação da luteína e zeaxantina sobre o risco de degeneração macular e/ou catarata (41) .…”

Section: Antioxidantes Sintéticosunclassified