Luteal phase support in fresh and frozen embryo transfers

Greenbaum, Shirley; Athavale, Ahlad; Klement, Anat Hershko; Bentov, Yaakov

doi:10.3389/frph.2022.919948

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…After the embryo has been transferred, luteal phase support (LPS) in the form of exogenous progesterone may be given for 8-10 weeks to support the endometrium. This is carried out to provide progesterone in place of the corpus luteum until the placenta can begin producing adequate amounts on its own, but is not always necessary [35].…”

Section: Era In the Context Of Natural Frozen Embryo Transfermentioning

confidence: 99%

Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications

Rubin

Abdulkadir

Lewis

et al. 2023

JPM

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Successful outcomes of in vitro fertilization (IVF) rely on both the formation of a chromosomally normal embryo and its implantation in a receptive endometrium. Pre-implantation genetic testing for aneuploidy (PGT-A) has been widely accepted as a tool to assess the viability of an embryo. In 2011, the endometrial receptivity array (ERA) was first published as a tool to determine when the endometrium is most receptive to an embryo, commonly referred to as the “window of implantation” (WOI). The ERA uses molecular arrays to assess proliferation and differentiation in the endometrium and screens for inflammatory markers. Unlike PGT-A, there has been dissent within the field concerning the efficacy of the ERA. Many studies that contest the success of the ERA found that it did not improve pregnancy outcomes in patients with an already-good prognosis. Alternatively, studies that utilized the ERA in patients with repeated implantation failure (RIF) and transfer of known euploid embryos demonstrated improved outcomes. This review aims to describe the ERA as a novel technique, review the various settings that the ERA may be used in, such as natural frozen embryo transfer (nFET) and hormone replacement therapy frozen embryo transfer (HRT-FET), and provide a summary of the recent clinical data for embryo transfers in patients with RIF utilizing the ERA.

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Section: Era In the Context Of Natural Frozen Embryo Transfermentioning

confidence: 99%

Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications

Rubin

Abdulkadir

Lewis

et al. 2023

JPM

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“…By addressing multiple aspects of this phase, such as progesterone levels and endometrial receptivity, these therapies create an environment conducive to optimal reproductive outcomes. This multifaceted approach ensures that all elements necessary for successful embryo implantation are nurtured, enhancing the chances of a viable pregnancy [ 68 ].…”

Section: Reviewmentioning

confidence: 99%

The Role of Dydrogesterone in the Management of Luteal Phase Defect: A Comprehensive Review

Muneeba,

Acharya,

Mohammad

2023

Cureus

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The luteal phase of the menstrual cycle is a pivotal period characterized by hormonal intricacies that lay the foundation for successful embryo implantation and early pregnancy development. Luteal phase defect (LPD), marked by abnormalities in luteal function, presents challenges that can impede reproductive outcomes. This comprehensive review article explores the role of dydrogesterone in LPD management, elucidating its mechanisms of action, evidence of efficacy, safety profile, and potential in combination therapies. Dydrogesterone, a synthetic progestogen, closely mirrors natural progesterone's actions, effectively supplementing the luteal phase and enhancing endometrial receptivity. Clinical studies demonstrate improved pregnancy rates, extended luteal phase support, and enhanced reproductive outcomes with dydrogesterone supplementation. Its favorable safety profile, minimal side effects, and reduced risk of unwanted hormonal effects contribute to its appeal. Furthermore, dydrogesterone's inclusion in international guidelines solidifies its importance in LPD management. Combination therapies, leveraging synergistic effects, offer a comprehensive approach. As gaps in knowledge persist, future research directions and personalized treatment strategies pave the way for a future where dydrogesterone stands as a beacon of hope in conquering the challenges of LPD and achieving successful reproductive outcomes.

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Comparative analysis of the effectiveness of vaginal forms of progesterone in IVF programs

Mayasina,

Buev,

Askerov

et al. 2023

Probl. reprod.

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Luteal phase support in fresh and frozen embryo transfers

Cited by 3 publications

References 40 publications

Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications

Review of Endometrial Receptivity Array: A Personalized Approach to Embryo Transfer and Its Clinical Applications

The Role of Dydrogesterone in the Management of Luteal Phase Defect: A Comprehensive Review

Comparative analysis of the effectiveness of vaginal forms of progesterone in IVF programs

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