Luteal phase estradiol level: a potential predictive marker for successful pregnancy in in vitro fertilization/intracytoplasmic sperm injection

Ganesh, Ashalatha; Goswami, S.K.; Chattopadhyay, Ratna; Chakraborty, Chandan; Chaudhury, Koel; Chakravarty, B.N.

doi:10.1016/j.fertnstert.2008.01.074

Cited by 21 publications

(19 citation statements)

References 26 publications

(26 reference statements)

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“…27,28 In this study a high midluteal E2 levels in high FORT was associated with better pregnancy outcome after ICSI as other studies also have documented improvement of results with a high mid luteal E2. 29,30 Our results to support the role of midluteal serum E2 in acquiring pregnancy are in contrast to a study of Ganesh et al in which midluteal serum E2 level was estimated 11 days after OI. 30 The low peak to mid luteal E2 observed in medium and high FORT groups in the present study emphasizes the role of midluteal E2 for decidualization of endometrium similar to another study.…”

Section: Discussioncontrasting

confidence: 99%

“…29,30 Our results to support the role of midluteal serum E2 in acquiring pregnancy are in contrast to a study of Ganesh et al in which midluteal serum E2 level was estimated 11 days after OI. 30 The low peak to mid luteal E2 observed in medium and high FORT groups in the present study emphasizes the role of midluteal E2 for decidualization of endometrium similar to another study. 26 Progesterone (P), a hormone of secretory phase causes mast cell maturation and release of cytokines and growth factors which are required for uterine receptivity.…”

Section: Discussioncontrasting

confidence: 99%

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Importance of estimation of Follicular output rate (FORT) in females assisted by intracytoplasmic sperm injection

Rehman

Mustafa

Hoor

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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Background: We aimed to estimate pregnancy outcome after ICSI in terms of oocyte parameters, embryo quality, endometrial thickness, hormone and cytokine levels in women stratified on the basis of follicular output rate (FORT). Methods: Quasi experimental design was carried out after approval from "Ethical review board of Islamabad clinic serving infertile couples" from July 2010 to August 2013. One thousand and fifty females were selected with the criteria of age between 21-40 years, infertility of more than 2 years, body mass index of 18-35 kg/m 2 , menstrual cycle of 25 ± 7 days, both ovaries present with normal uterine cavity, serum FSH levels less than 8 IU/ml and normal thyroid-stimulating hormone levels. Females on short agonist or antagonist protocol with diagnosis of polycystic ovarian syndrome, fibroids or in their male partner sperms retrieved by testicular biopsy were excluded from the study. Down regulation of ovaries was followed by controlled ovarian stimulation, Ovulation Induction (OI), oocyte pick up, in vitro fertilization, Embryo Transfer (ET) and confirmation of pregnancy was done by serum beta hCG of more than 25 mIU/ml and cardiac activity on trans vaginal scan. Enzyme linked immuno sorbent assay was used for peak and mid luteal estradiol (E2), progesterone (P) and interleukin I-β estimation on OI and ET days respectively. FORT (ratio of preovulatory follicle count to antral follicle count × 100 on OI day) stratified females into low under the 33 rd percentile, medium between the 33 rd and the 67 th percentile and high above the 67 th percentile. Characteristics of groups were compared by one way analysis of variance. Results: Females 276 (33%), 288 (34%) and 282 (33%) comprised of low, medium and high FORT groups respectively. The number of retrieved, mature and fertilized oocytes, cleaved embryos, endometrial thickness and number of gestational sacs in the high FORT group was significantly high (P <0.001). High peak and midluteal E2 (P = 0.0025, 0.0001), low P (P = 0.0001) and high peak interleukin-1β (P = 0.0001) was observed in high FORT in comparison with medium FORT with resultant greater number of clinical pregnancies 183 (65%). Conclusions: The FORT in non PCOS patients may reflect good reproductive outcome after ICSI with maximum clinical pregnancies in high FORT group.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Importance of estimation of Follicular output rate (FORT) in females assisted by intracytoplasmic sperm injection

Rehman

Mustafa

Hoor

et al. 2015

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Furthermore, 80% of those pregnancies achieved in the latter group resulted in miscarriage. Ganesh et al (8) examined the luteal phase hormone profile in pregnant and nonpregnant woman after IVF and found significantly higher day-21 and day-28 E 2 levels in conception vs. nonconception cycles. In a prospectively designed study, Sonntag et al (3) reported higher levels of E 2 beginning 7 days after ET in cycles resulting in pregnancy compared with those cycles with a negative outcome.…”

Section: Discussionmentioning

confidence: 99%

How low is too low? Cycle day 28 estradiol levels and pregnancy outcomes

Melnick

Pereira

Murphy

et al. 2016

Fertility and Sterility

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“…One recent report noted that occurrence of conception did not correlate with the absolute midluteal level of serum E 2 or with percent E 2 decline (50), but other investigators reported that midluteal E 2 level was significantly higher in a pregnant group (51).…”

Section: Discussionmentioning

confidence: 99%

Effects of estradiol supplementation during the luteal phase of in vitro fertilization cycles: a meta-analysis

Jee

Suh

Kim

et al. 2010

Fertility and Sterility

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Luteal phase estradiol level: a potential predictive marker for successful pregnancy in in vitro fertilization/intracytoplasmic sperm injection

Cited by 21 publications

References 26 publications

Importance of estimation of Follicular output rate (FORT) in females assisted by intracytoplasmic sperm injection

Importance of estimation of Follicular output rate (FORT) in females assisted by intracytoplasmic sperm injection

How low is too low? Cycle day 28 estradiol levels and pregnancy outcomes

Effects of estradiol supplementation during the luteal phase of in vitro fertilization cycles: a meta-analysis

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