Luteal control of endometrial receptivity and its modification by progesterone antagonists.

Hegele‐Hartung, Christa; Mootz, Ursula; Beier, Henning M.

doi:10.1210/endo.131.5.1425442

Cited by 27 publications

(10 citation statements)

References 32 publications

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“…In the rabbit, uteroglobin is the key marker molecule within the protein pattern of receptivity. 82,83 The transfer of successful achievements in reproductive biology from the rabbit model to human reproductive biology and medicine will lead to beneficial applications in assisted reproduction. 92,93 From the very beginning, uteroglobin was implicated in blastocyst formation, expansion, and/or attachment because it was detected in blastocyst fluid in vivo 21 and in vitro 94 as well as in the uterine milieu.…”

Section: The Uteroglobin Model: Certainly a Benefit To Reproductive Bmentioning

confidence: 99%

“…Experimental interference from steroid hormone regulation in the preimplantation period led to the discovery of the transposition of the implantation window. 43,79–83 The pattern of secreted uterine proteins, in particular the uteroglobin fraction and the β‐glycoprotein fraction, served to identify the biological stage of the intrauterine microenvironment during preimplantation. These protein profiles allowed us to precisely predict the receptive stage of the endometrium so that donated transferred blastocysts achieved successful implantation.…”

Section: The Uteroglobin Model: Certainly a Benefit To Reproductive Bmentioning

confidence: 99%

Section: The Uteroglobin Model: Certainly a Benefit To Reproductive Bmentioning

confidence: 99%

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The Discovery of Uteroglobin and Its Significance for Reproductive Biology and Endocrinology

Beier

2000

Annals of the New York Academy of Sciences

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The discovery of uteroglobin resulted from investigations on the biochemical composition of oviductal and uterine secretions of the rabbit and other mammals. These determinations about physiological composition were urgently requested to prepare culture media for research on early mammalian development in vitro. Discovery of significant proteins during the sixties reflected the laboratory skills of that time. Protein characterization was achieved by isolation via Sephadex gels, electrophoresis on polyacrylamide gels, and finally immunoprecipitation using classical polyclonal antibodies. The molecular biology was not yet established. Uteroglobin could be found as the major protein component of rabbit uterine secretion. From the beginning, it was already identified as an unusually small, spheric uterine secretory molecule without any carbohydrates‐hence its name. Uteroglobin was the first mammalian protein that turned out to be progesterone‐regulated and, at the same time, released in mg amounts actually in one organ compartment. Moreover, uteroglobin and its gene proved to be a reliable model for the description of progesterone/progesterone receptor complex action at the DNA level. After its original observation in the uterus, however, uteroglobin was detected also in several other organs, for example, the epididymis, the seminal vesicle, and the lung. Initially, it could not be found in the blood, which challenged the hypothesis that uteroglobin specifically should operate by local activation rather than by a humoral or endocrine effect. Later, though, the human uteroglobin molecule, isolated from blood filtrate, was used for detailed structural analyses. The rabbit uteroglobin model certainly was beneficial for reproductive biological research. Experimental interference with steroid hormone regulation during preimplantation presented surprising effects, which led to the discovery of the transposition of the implantation window. The uterine secretion protein patterns, in particular the uteroglobin fraction and the β‐glycoprotein fraction, served as decisive marker profiles to identify the biological stage of the intrauterine microenvironment during preimplantation. This diagnostic procedure, using only protein parameters, enabled us to precisely predict the receptive stage of the endometrium for donated blastocysts to achieve implantation successfully.

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Section: The Uteroglobin Model: Certainly a Benefit To Reproductive Bmentioning

confidence: 99%

Section: The Uteroglobin Model: Certainly a Benefit To Reproductive Bmentioning

confidence: 99%

Section: The Uteroglobin Model: Certainly a Benefit To Reproductive Bmentioning

confidence: 99%

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The Discovery of Uteroglobin and Its Significance for Reproductive Biology and Endocrinology

Beier

2000

Annals of the New York Academy of Sciences

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“…It is generally accepted that P drives the differentiation of the endometrial epithelium. 4,5 Thus, we investigated the effects of the preovulatory P serum peak within the first 10 hours after the hCG injection and the effects of the following transient rise in the P serum concentration on d2 p‐hCG. 6 The endometrial P effects were studied by the specific inhibition of P action by a single application of the P receptor antagonist ONA.…”

Section: Resultsmentioning

confidence: 99%

Uteroglobin In Situ Hybridization: Novel Monitoring of Epithelial Differentiation in the Rabbit Endometrium

Krusche

Herrler

Beier

2000

Annals of the New York Academy of Sciences

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“…Estrogene beeinflussen die Permeabilita Èt der Kapillarendothelien, also die Transsudation. Progesteron kontrolliert besonders die sekretorische Aktivita Èt und die Apoptosevorga Ènge des endometrialen Epithels [31,46,55] 23 Bischof P, Redard M, Gindre P, Vassilkos P, Campana A. Localization of alpha 2, alpha 5, and alpha 6 integrin subunits in…”

Section: Das Endometriale Sekretunclassified

Die implantationsgerechte Lutealphase des Endometriums.Zum Stand der molekularen und zellbiologischen Forschung

Beier¹,

Beier-Hellwig²,

Sterzik³

2001

Zentralbl Gynakol

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The biological aim of the differentiation and maturation of endometrial tissue compartments during any menstrual cycle is the achievement of suitable conditions for blastocyst implantation and the establishment of pregnancy. Infertility and early embryonic loss are frequently caused by insufficient endometrial differentiation. Even any incomplete receptivity stage of the luteal phase endometrium will prevent attachment and implantation. We have studied the physiological changes throughout an endometrial cycle to elucidate causes of endometrial insufficiency leading to subfertility or infertility. Up to now, the histological changes described by Noyes et al. are understood as classical diagnostic approaches. However, evidence is accumulating that molecular deficits of endometrial differentiation are by no means detectable histologically, and consequently ask for the research on new diagnostic methods and parameters. There are histochemical localizations of specific protein molecules, adhesion molecules and cytokines, which permit by far more detailed and significant molecular analyses than any classical morphological means could yield. Moreover, there are convincing arguments to use further biochemical assessments on proteins of the uterine secretions as specific diagnostic parameters. The electrophoretical resolution presents typical protein patterns, which in turn can be interpreted as characteristic reflexions of the functional phases of the endometrial cycle. What is demonstrated as the so-called adequate luteal phase protein pattern clearly is the product of the receptive endometrium, reflecting the "implantation window". This is established already two days after ovulation and persists usually eight further days, if the endometrial cycle is undisturbed (15th to 24th day of the cycle).

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Luteal control of endometrial receptivity and its modification by progesterone antagonists.

Cited by 27 publications

References 32 publications

The Discovery of Uteroglobin and Its Significance for Reproductive Biology and Endocrinology

The Discovery of Uteroglobin and Its Significance for Reproductive Biology and Endocrinology

Uteroglobin In Situ Hybridization: Novel Monitoring of Epithelial Differentiation in the Rabbit Endometrium

Die implantationsgerechte Lutealphase des Endometriums.Zum Stand der molekularen und zellbiologischen Forschung

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