Lurasidone-Induced Rabbit Syndrome

Can Isolated Head Tremors Be an Extrapyramidal Symptom Associated with Lurasidone?—A Case Series

“…13 Lurasidone-induced Parkinsonism, severe EPS, and rabbit syndrome had also been reported. [14][15][16] It was suggested that the high affinity of lurasidone for D2 receptors in the nigrostriatal tract, in combination with poor anticholinergic activity, could lead to drug-induced Parkinsonism. Even though earlier studies 4,5 reported fewer EPS with lurasidone, the meta-analysis by Leucht et al 17 identified that lurasidone was one among the five second-generation antipsychotics with significantly more EPS than placebo (OR = 2.46; 95% CI: 1.55-3.72).…”

Lurasidone-induced Parkinsonism and Hyperprolactinemia

“…When compared to other antipsychotics, its side effect profile is similar to aripiprazole, asenapine, and amisulpride for weight gain; while in the case of DIP and hyperprolactinemia, it is similar to asenapine, chlorpromazine, ziprasidone, and olanzapine. Recently, two case reports mentioned the development of restless leg syndrome[ 7 ] and rabbit syndrome[ 8 ] in female patients treated with 40–120 mg of lurasidone. A recent meta-analysis of efficacy and tolerability of various antipsychotics in schizophrenia concluded that lurasidone more frequently leads to extrapyramidal side effects (odds ratio = 2.46; confidence interval = 1.55–3.72) as well as hyperprolactinemia (standard mean difference/SMD = 0.34; confidence interval = 0.11–0.57) when compared to placebo.…”

Risk of Drug-induced Movement Disorders with Newer Antipsychotic Agents

“…A DBRCT (n = 496) with placebo control, using a 20-week stabilization phase and subsequent 28 week treatment period in BPD showed similar rates of DIMD as other long-term studies [ 71 ]. Case reports have identified individuals with TD, drug-induced parkinsonism, rabbit syndrome, and laryngospasm with lurasidone-exposure [ 72 73 74 75 76 ].…”