Lupusnephritis

Melderis, Simon; Wiech, Thorsten; Iking-Konert, C.; Steinmetz, Oliver M.

doi:10.1007/s00393-018-0496-4

Cited by 12 publications

(7 citation statements)

References 48 publications

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“…The main clinical manifestations of LN patients are proteinuria, hematuria, sterile pyuria, tubular urine, hypertension, edema, deterioration of renal function, and hypoproteinemia. 17,21 In our study, significant differences were detected in prevalence of arthritis, alopecia, and mucosal ulcers in SLE patients with and without LN (all p < .05), which was similar to foreign studies. 22,23 In addition, persistent proteinuria and renal impairment are independent risk factors for progression to chronic kidney disease and even death in patients with LN.…”

Section: Discussionsupporting

confidence: 91%

Analysis of risk factors and development of a nomogram prediction model for lupus nephritis in systemic lupus erythematosus patients

Zhen

Wang

Qin

et al. 2023

Lupus

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Background This study aimed to explore risk factors for lupus nephritis (LN) in systemic lupus erythematosus (SLE) patients and establish a Nomogram prediction model based on LASSO-logistic regression. Methods The clinical and laboratory data of SLE patients in Meishan People’s Hospital from July 2012 to December 2021 were analyzed retrospectively. All SLE patients were divided into two groups with or without LN. Risk factors were screened based on LASSO-logistic regression analysis, and a Nomogram prediction model was established. The receiver operating characteristic curve, calibration curves, and decision curve analysis were adopted to evaluate the performance of the Nomogram model. Results A total of 555 SLE patients were enrolled, including 303 SLE patients with LN and 252 SLE patients without LN. LASSO regression and multivariate logistic regression analyses showed that ESR, mucosal ulcer, proteinuria, and hematuria were independent risk factors for LN in SLE patients. The four clinical features were incorporated into the Nomogram prediction model. Results showed that calibration curve was basically close to the diagonal dotted line with slope 1 (ideal prediction case), which proved that the prediction ability of the model was acceptable. In addition, the decision curve analysis showed that the Nomogram prediction model could bring net clinical benefits to patients when the threshold probability was 0.12–0.54. Conclusion Four clinical indicators of ESR, mucosal ulcer, proteinuria, and hematuria were independent risk factors for LN in SLE patients. The predictive power of the Nomogram model based on LASSO-logistic regression was acceptable and could be used to guide clinical work.

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Section: Discussionsupporting

confidence: 91%

Analysis of risk factors and development of a nomogram prediction model for lupus nephritis in systemic lupus erythematosus patients

Zhen

Wang

Qin

et al. 2023

Lupus

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“…Lupus nephritis (LN) is one of the most common causes of mortality and morbidity. SLE patients with LN have about sixfold higher mortality rates than those without LN [2]. Over the recent few decades, the 10-year survival rate of LN has dramatically improved from 46 to 95% among patients who achieved disease remission [3].…”

Section: Introductionmentioning

confidence: 99%

Autoantibodies spectrum in lupus nephritis in a cohort of Egyptian patients: relation to disease activity and prognostic value

Elsayed

Mohafez

2020

Egypt Rheumatol Rehabil

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Background Specific autoantibodies are considered as an important marker in autoimmune rheumatic diseases and are of great value for the diagnosis and prognosis of systemic lupus erythematosus (SLE) patients. A total of eighteen autoantibodies were analyzed for their positivity in SLE patients and we evaluated the clinical relevance of the five most frequent autoantibodies: anti-dsDNA, anti-nucleosome, anti-histone, anti-Ro60, and anti-Ro52 on disease activity and renal affection in SLE Egyptian patients. Results Immunological profile and correlation of the five autoantibodies with disease activity and histopathological pattern of renal involvement were analyzed for 190 SLE patients. Lupus nephritis (LN) patients showed much worse constitutional and mucocutaneous manifestations than patients without nephritis. Autoantibody profile showed a significant increased frequency of anti-dsDNA, anti-nucleosome, anti-histone, anti-Ro-60, and anti-Ro52 antibodies in LN patients. The impact of the co-positivity of the autoantibodies on the renal function was obvious. Moreover, the disease activity increased by the increased frequency of autoantibodies positivity in LN patients. ROC curve analysis showed that anti-nucleosome had the highest sensitivity; 93% followed by anti-dsDNA 83.3% then anti-histone 73.8%, but anti-Ro60 and anti-Ro52 showed a humble sensitivity. Furthermore, the highest frequency of positivity for the five autoantibodies was found in class-III and class-IV LN patients. Conclusion Detection of anti-dsDNA, anti-nucleosome, anti-histone, and anti-Ro60 in SLE patients may be important for predicting disease progression and kidney affection. Moreover, anti-nucleosome and anti-dsDNA show high sensitivity and specificity for lupus nephritis, thus patients with four to five positive autoantibody panels should be kept under close monitoring as they may warrant considering aggressive therapy to control their disease and prevent renal damage.

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“…[19,20] Proteinuria can indicate potential kidney disorders, suggestive for the presence of LN. [21] With regard to autoimmune antibodies, anti-dsDNA as one of nephrotoxic autoantibodies can directly involve in renal pathology of SLE [22,23] and increased incidence of LN, [24] of which one of the reasons is immune complex with anti-dsDNA can lead to renal inflammation if deposited in kidney, [25] and may result in activation of complement, reactive oxygen species and some cytokines which are also causative factors of LN. [26] Moreover, positive anti-Sm, anti-RNP [27–29] and biomarkers for inflammation such as interleukin [30–32] are also associated with renal involvement.…”

Section: Discussionmentioning

confidence: 99%

Association of GTF2I gene polymorphisms with renal involvement of systemic lupus erythematosus in a Chinese population

Yang¹,

Zhang²,

Xie

et al. 2019

Medicine

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The purposes of the study was to validate the relationship between General transcription factor II-I (GTF2I) genetic variants and kidney involvements of systemic lupus erythematosus (SLE) patients in a Chinese Han population. Samples from 400 SLE patients and 400 age- and sex-matched healthy controls were collected and genotyped by improved multiplex ligation detection reaction technique. The relationship between gene polymorphism of rs117026326, rs73366469, and susceptibility, progression of SLE were analyzed. The present study provided evidence that rs117026326 and rs73366469 were both associated with SLE susceptibility (both C vs T: P < .001). The analysis of dominant, recessive disease model provided us with further validation ( P < .001). Both gene polymorphisms are associated with a triad of disease manifestations among SLE patients. Patients carrying genotype TT of rs117026326 had lower 24-hour urinary total protein (24 hours UTP, g/24 hours), 24-hour urinary protein level (g/L·24 hours), lower frequency of the proteinuria and lupus nephritis (LN). Patients carrying genotype TT at rs73366469 had higher 24-hour urinary protein level, higher frequency of the proteinuria, LN and positive anti-dsDNA than those with other genotypes. This study identified the involvement of GTF2I gene polymorphisms in development of SLE, particularly in renal involvement.

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Lupusnephritis

Cited by 12 publications

References 48 publications

Analysis of risk factors and development of a nomogram prediction model for lupus nephritis in systemic lupus erythematosus patients

Analysis of risk factors and development of a nomogram prediction model for lupus nephritis in systemic lupus erythematosus patients

Autoantibodies spectrum in lupus nephritis in a cohort of Egyptian patients: relation to disease activity and prognostic value

Association of GTF2I gene polymorphisms with renal involvement of systemic lupus erythematosus in a Chinese population

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