Lupus vulgaris with tubercular lymphadenitis and IgA nephropathy

Abstract

A 14-year-old girl presented with a 10-year history of a large crusted plaque over the right thigh for 10 years and small reddish plaque over the left upper back for 3 months. On routine evaluation, she was found to have hematuria. Skin biopsy from the lesion was suggestive of skin tuberculosis (lupus vulgaris), and kidney biopsy showed features of IgA nephropathy (IgAN). Fine-needle aspiration from the inguinal lymph node was consistent with granulomatous disease. The patient has been on anti-tubercular treatment, and the hematuria has subsided.

Tuberculosis-associated IgA nephropathy

“…Haematuria and culture-negative pyuria may be noted during urine analysis. 6 Although some TB-IgAN cases have been documented in the English language literature, [34][35][36][37][38][39][40][41][42] a greater understanding of the clinical characteristics of TB-IgAN is necessary to raise awareness and improve disease treatment. As shown in Table 1, the clinical manifestations of TB-IgAN are atypical and nonspecific.…”