Lupus Vulgaris an Unusual Fungating and Ulcerated Form in a Black South African

Dogliotti, M; Leibowitz, Michael R.; Smith, Emily H.

doi:10.1111/j.1365-4362.1979.tb05012.x

Cited by 7 publications

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“…Other unusual features of cutaneous tuberculosis have been reported in the literature. 2–4 Gangrenous or vegetating forms of cutaneous tuberculosis with underlying lung or glandular disease have been reported. 2 Lee et al .…”

Section: Reportmentioning

confidence: 99%

“… 2–4 Gangrenous or vegetating forms of cutaneous tuberculosis with underlying lung or glandular disease have been reported. 2 Lee et al . 3 reported an unusual form of cutaneous tuberculosis following BCG vaccination.…”

Section: Reportmentioning

confidence: 99%

“…2±4 Gangrenous or vegetating forms of cutaneous tuberculosis with underlying lung or glandular disease have been reported. 2 Lee et al 3 reported an unusual form of cutaneous tuberculosis following BCG vaccination. Sehgal et al 4 reported two unusual patients with multifocal guttate tuberculosis verrucosa cutis and necklace lupus vulgaris.…”

Section: Reportmentioning

confidence: 99%

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Tuberculous cellulitis

Lee

Choi

Lee

et al. 2000

Clinical and Experimental Dermatology

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We report a case of cutaneous tuberculosis presenting as cellulitis. The patient was a 63-year-old Korean woman who also had diabetes mellitus and a 20-year-history of oral corticosteroid medication prescribed for arthralgia. In addition, she had had pulmonary tuberculosis 20-year previously for which she received systemic treatment for 1 year. Her clinical cellulitis failed to respond to antibiotic therapy. Subsequent investigations, using histopathology and polymerase chain reaction, established an alternative diagnosis of cutaneous tuberculosis. The skin eruption cleared after treatment with isoniazid, rifampicin, ethambutol and pyrazinamide. This case represents a most unusual presentation of tuberculosis in the skin. The atypical features may reflect the patient's general medical state.

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Section: Reportmentioning

confidence: 99%

Section: Reportmentioning

confidence: 99%

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Tuberculous cellulitis

Lee

Choi

Lee

et al. 2000

Clinical and Experimental Dermatology

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“…Dogliotti et al . recorded an unusual fungating, ulcerated form of lupus vulgaris on the forehead of a 42‐year‐old South African man which had been present for 12 years 10 …”

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confidence: 99%

Lupus vulgaris diagnosed after 87 years, presenting as an ulcerated 'birthmark'

Woo¹,

Batta²,

Tan³

et al. 2002

Br J Dermatol

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“…Despite stringent control measures adopted in India under the National Tuberculosis Control Programme (NTCP), it continues to be a major infective disorder. 8 In a typical case of LV, marked tuberculin sensitivity is exhibited. Although LV is a benign condition, simultaneous association with tuberculosis elsewhere has been reported in 9±19% of cases.…”

Section: Discussionmentioning

confidence: 97%

An unusual episode of lupus vulgaris masquerading as sporotrichosis

2001

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Case 1 A 24‐year‐old man presented with asymptomatic, gradually progressive plaques and nodules over the right knee extending to the thigh in a linear pattern of 3 months' duration. A year previously, he had been diagnosed with tuberculosis of the spine and had been advised to take antitubercular treatment; however, he chose to stop treatment on his own after 4 months of therapy as his spinal condition improved with a marked decrease in pain. There was no history of fever, systemic complaints, or any spinal or knee injury preceding the disease. His mother had received treatment for pulmonary tuberculosis 4 years previously. Dermatologic examination revealed well‐defined, brownish papules, plaques, and nodules of variable sizes, ranging from 3 cm to 6 cm, present over the right knee and front of the thigh in a linear pattern. The lesions were soft in consistency with ‘‘apple‐jelly’' nodules and the surrounding skin showed atrophic scarring (Fig. 1). 1 Plaques and nodules in a sporotrichoid distribution over the right lower limb (Case 1) All the hematologic and biochemical investigations were normal except for an elevated erythrocyte sedimentation rate (ESR) (48 mm/1 h). Venereal disease research laboratory (VDRL) test, enzyme‐linked immunoabsorbent assay (ELISA) for human immunodeficiency virus (HIV), and sputum examination for acid‐fast bacilli (AFB) were negative. Mantoux test with 1 tuberculin unit (TU) of purified protein derivative‐standard (PPD‐S) showed an induration of 25 × 20 mm. Blood culture and culture of the tissue homogenate for Mycobacterium tuberculosis, atypical mycobacteria, and fungal organisms revealed no growth. Slit skin smears from the plaque showed only lymphocytes and a few neutrophils. Immunoenzymatic test (ELISA) for antimycobacterial immunoglobulin M (IgM) antibody against the A 60 antigen complex was strongly positive (> 1 : 200 U). Histopathologic examination revealed a hypertrophic epidermis with noncaseating tuberculoid granulomas consisting of lymphohistiocytes, epithelioid cells, and Langhans' giant cells in the papillary and upper reticular dermis (Fig. 2a,b). No AFB were detected. Polymerase chain reaction (PCR) and guinea pig inoculation could not be performed due to a lack of facilities. 2 (a) Photomicrograph showing noncaseous tuberculoid granulomas in the papillary dermis (hematoxylin and eosin, × 40); (b) photomicrograph showing Langhans' giant cells (arrow) in the dense granuloma Skiagram of the chest was normal, although X‐ray of the lumbosacral spine revealed bony destruction of the sacral foramina. A magnetic resonance image (MRI) in the sagittal and axial plane was suggestive of caries of the fifth lumbar and sacral vertebrae with a large presacral and anterior epidural collection (Fig. 3). Computed tomography (CT) scan‐guided abscess drainage of the sacral region was performed and microscopic examination of the fluid revealed lymphocytes, polymorphs, macrophages, and a few AFB in a necrotic background. 3 Magnetic resonance image in the sagittal plane: caries ...

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Lupus Vulgaris an Unusual Fungating and Ulcerated Form in a Black South African

Cited by 7 publications

References 0 publications

Tuberculous cellulitis

Tuberculous cellulitis

Lupus vulgaris diagnosed after 87 years, presenting as an ulcerated 'birthmark'

An unusual episode of lupus vulgaris masquerading as sporotrichosis

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