Lupus retinopathy: a marker of active systemic lupus erythematosus

Seth, Gaurav; Chengappa, K G; Misra, Durga Prasanna; Babu, R; Belani, Pooja; Shanoj, K. C.; Kumar, Gunjan; Negi, Vir Singh

doi:10.1007/s00296-018-4083-4

Cited by 36 publications

(34 citation statements)

References 17 publications

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“…We found that the mean age at SLE onset in patients with and without fundus abnormalities was 34 and 29 years, respectively, similar to previous studies. 3 , 16 , 18 , 19 We also found that patients with fundus abnormalities had higher SLE disease activity, in agreement with the previously published literature. 20 , 21 It is known that SLE is a multisystem autoimmune disease and fundus abnormalities are probably indicative of disease activity.…”

Section: Discussionsupporting

confidence: 92%

Anti-recoverin antibodies indicate fundus abnormalities in systemic lupus erythematosus

Chen

Wang

et al. 2020

Lupus

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Objectives Lupus fundus abnormalities are a sight-threatening complication of systemic lupus erythematosus (SLE) and its pathogenesis remains to be studied. The aim of this study was to assess the clinical characteristics associated with the presence of anti-recoverin antibodies in patients with SLE, especially those with fundus abnormalities. Methods Seventy-six participants were enrolled, including 21 patients with fundus abnormalities (fundus group), 30 patients without fundus abnormalities (non-fundus group) and 25 healthy individuals. Serum anti-recoverin antibody levels were measured using enzyme-linked immunosorbent assay, and clinical and laboratory data were obtained from medical records. Results Compared with the non-fundus group, the fundus group had a higher incidence of hematuria ( p < 0.05). The Systemic Erythematosus Disease Activity Index (SLEDAI) score in the fundus group was significantly higher than the non-fundus group (21.48 ± 8.06 versus 10.80 ± 5.74, p < 0.001). The levels of serum anti-recoverin antibodies in the fundus group were significantly higher than the non-fundus group ( p = 0.029) or the healthy control group ( p = 0.011). Anti-recoverin-negative and -positive patients differed on a number of clinical parameters, including incidence of fever, rash, antinuclear antibody, anti-dsDNA antibody, erythrocyte sedimentation rate, immunoglobulin G, complement C3 and complement C4. The average SLEDAI score of anti-recoverin-positive patients was significantly higher than anti-recoverin-negative patients (17.73 ± 8.11 versus 12.56 ± 8.37, p < 0.05). Conclusions Anti-recoverin antibodies were related to higher disease activities in SLE, especially those with fundus abnormalities, suggesting that anti-recoverin antibodies may play an important role in the pathogenesis of fundus abnormalities in SLE.

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Section: Discussionsupporting

confidence: 92%

Anti-recoverin antibodies indicate fundus abnormalities in systemic lupus erythematosus

Chen

Wang

et al. 2020

Lupus

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“…LR prevalence in our study was lower than other studies in different populations. However, our study had similar results regarding two clinical data: type of LR and disease activity [1][2][3].…”

Section: Clinical Demographic Datasupporting

confidence: 75%

Lupus retinopathy: epidemiology and risk factors

Azevedo

Biancardi

Silva

et al. 2021

Arquivos Brasileiros De Oftalmologia

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Lupus retinopathy (LR) is a clinical presentation of systemic lupus erythematosus (SLE) in the visual system, which is closely associated with inflammatory activity of the SLE and may lead to irreversible visual loss. Its pathophysiology is believed to be mainly linked to the deposition of immune complexes in the retinal microvasculature leading to vascular occlusions, microinfarcts and retinal vasculitis.LR prevalence and associated factors are well defined in some parts of the world [1-3]. However, these data are not known in Latin America, including Brazil. Systemic Lupus Erythematous (SLE) has distinct features in Latin America when compared with other countries [4]. It is not known if these different characteristics could influence the occurrence of LR. Thus, it is important to describe relevant clinical demographic data of LR in these patients, especially because there is an association between LR and a higher mortality of SLE patients [5].

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“…Autoimmune process can affect the retina and choroid in two ways: direct, by immune complexmediated vasculitis; and indirect, by secondary hypertension influenced by the kidney. 11 There are 3 direct retinal damages caused by SLE, which are: microangiopathy, severe vaso-occlusion, and vasculitis. Ocular manifestations due to SLE, particularly lupus retinopathy, are caused by autoimmune dysregulation activity where immune complex is a crucial contributor for the occurrence Posterior uveitis in SLE patients is a rarelyoccurring complication with an incidence of 1.4%.…”

Section: Discussionmentioning

confidence: 99%

Systemic Lupus Erythematosus Disease Activity Correlated With Posterior Segment Manifestations Using Mex-Sledai Score

et al. 2021

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Introduction: Lupus retinopathy and posterior uveitis are complications due to systemic lupus erythematosus which can threaten the vision. The presence of posterior segment manifestation is suggestive of high disease activity. The aim of this study is to identify posterior segment manifestation (Lupus Retinopathy and Posterior Uveitis) in SLE patient and their correlation with SLE disease activity using The Mexican-SLEDAI (MEX-SLEDAI) score. Methods: This was an analytical observational study with cross-sectional design, conducted from August to October 2020 and involved 114 SLE patients in Dr. Saiful Anwar General Hospital. We calculated MEX-SLEDAI score to assess SLE disease activity. All participant that met inclusion criteria underwent ophthalmology examinations using a portable slit-lamp, head indirect ophthalmoscope, and fundus finding were documented using portable fundus imaging. Result: Lupus retinopathy (LR) presents in 25/114 (21.9%) and posterior uveitis (PU) occurs in 2/114 (1.8%) SLE patients. The mean age of patient with LR, PU, and without retinopathy were 32.92; 37.00; and 31.08 years respectively. The posterior segment findings were hemorrhages, cotton wool spots, hard exudates, and vasculitis reflecting vascular damage. The most common manifestation found in retina was cotton wool spot. The mean of MEX-SLEDAI score of SLE patient with LR (7.200 ± 3.905) and SLE patient with PU (3.500 ± 2.121) was higher than the mean of SLE patient without LR and PU (2.871 ± 2.534). There was a significant association between LR and MEX-SLEDAI score (p=0.000). An insignificant association between PU and MEX-SLEDAI score was found (p=0.353) Conclusion There is a significance correlation between lupus retinopathy and SLE disease activity based on MEX-SLEDAI scores. The mean of MEX-SLEDAI score in SLE patients with lupus retinopathy was higher than SLE with posterior uvetis and SLE without posterior segment manifestations.

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Lupus retinopathy: a marker of active systemic lupus erythematosus

Cited by 36 publications

References 17 publications

Anti-recoverin antibodies indicate fundus abnormalities in systemic lupus erythematosus

Anti-recoverin antibodies indicate fundus abnormalities in systemic lupus erythematosus

Lupus retinopathy: epidemiology and risk factors

Systemic Lupus Erythematosus Disease Activity Correlated With Posterior Segment Manifestations Using Mex-Sledai Score

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