Lupus néonatal et transmission materno-fœtale des anticorps anti-SSA/Ro et anti-SSB/La

Feki, S.; Turki, A.; Frikha, F.; Hachicha, H.; Walha, L.; Gargouri, A.; Bahloul, Z.; Masmoudi, Hatem

doi:10.1016/j.arcped.2014.10.020

Cited by 4 publications

(9 citation statements)

References 19 publications

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“…The neonatal with tetralogy of Fallot died at the second day after birth. Neonatal lupus and neonatal heart disease do not appear to be significantly associated with the new-onset lupus during pregnancy or LN pregnancies, which may be associated with the anti-Ro/SSA and anti-La/SSB[ 42 , 43 ] and needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes in Chinese Patients with Systemic Lupus Erythematosus (SLE): A Retrospective Study of 109 Pregnancies

Guo

Shi

et al. 2016

PLoS ONE

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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that primarily affects women during their reproductive years. The interaction between SLE and pregnancy remains debated. The objective of this study was to analyze the fetal and maternal outcomes of Chinese women with SLE. A total of 109 pregnancies in 83 SLE patients from June 2004 to June 2014 at a tertiary university hospital were reviewed retrospectively. Patients’ characteristics, clinical and laboratory data during pregnancy were obtained from electronic medical records. After exclusion of elective abortions, the live birth rate was 61.5%. Significantly, APS (antiphospholipid syndrome), disease activity, hypertension, hypocomplementemia, thrombocytopenia, and anemia during pregnancy were more commonly observed in fetal loss pregnancies than in live birth pregnancies. Compared to the 64 women with a history of SLE, 19 women with new-onset lupus during pregnancy had worse pregnancy outcome. Furthermore, the 64 patients with a history of SLE were divided into lupus nephritis group and SLE group (non-renal involvement). We found that the lupus nephritis group had worse maternal outcome than the SLE group. We conclude that new-onset lupus during pregnancy predicts both adverse maternal and fetal outcomes, while a history of lupus nephritis predicts adverse maternal outcomes. It is essential to provide SLE women with progestational counseling and regular multispecialty care during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes in Chinese Patients with Systemic Lupus Erythematosus (SLE): A Retrospective Study of 109 Pregnancies

Guo

Shi

et al. 2016

PLoS ONE

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“…So far, three groups of autoantibodies against membrane surface antigens have been identified in conjunction with maternal–fetal transfer: (1) N -methyl- d -aspartate receptor (NMDAR) antibodies (Wang et al 2012 ; Jurek et al 2019 ; Lee et al 2009a ), (2) Contactin - associated protein - like 2 (CASPR2) antibodies (Coutinho et al 2017a , b ; Brimberg et al 2016 ; Bagnall-Moreau et al 2020 ) and (3) antibodies against the 37 and 73 kDa proteins (Braunschweig et al 2013 ). Furthermore, although our review focuses on membrane surface autoantibodies, we call brief attention to evidence of the maternal–fetal transfer of anti-Sjögren's-syndrome-related antigen A (SSA) (Ro) and anti-SSB (La) and anti-ribonucleoprotein 1 (RNP) autoantibodies in mothers with lupus erythematosus (Feki et al 2015 , Zurgil et al 1993 ) to better decipher the spectrum of potential maternal–fetal transfer of autoantibodies.…”

Section: Resultsmentioning

confidence: 99%

Autoantibody-associated psychiatric syndromes in children: link to adult psychiatry

et al. 2021

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Studies show that psychiatric symptoms in adults and children are sometimes associated with serum neural autoantibodies. The significance of serum neural autoantibodies associated with psychiatric symptoms in children remains often unclear, but might be relevant for the extent and occurrence of psychiatric disease manifestation in later life, as well as therapy and outcome. For this narrative review, we sought articles listed in PubMed and published between 1988 and 2020 addressing the maternal–fetal transfer of neural autoantibodies and psychiatric disorders associated with serum neural autoantibodies. We identified six major subgroups of psychiatric disorders in children that are associated with serum neural autoantibodies: patients with attentional deficit hyperactivity disorder, autism spectrum disorder, obsessive compulsive disorder, Gilles de la Tourette syndrome, psychosis and catatonia. Furthermore, we summarized study findings from maternal–fetal transfer of Contactin-associated protein-like 2, N-methyl-d-aspartate receptor and fetal brain autoantibodies associated with behavioral effects in animals and humans. We hypothesize that the maternal transfer of serum neuronal autoantibodies during or after birth could result (1) in the ignition of an autoimmune-mediated inflammation having neurodevelopmental consequences for their children (autoimmune-priming-attack hypothesis) and (2) has a potential impact on the later manifestation of psychiatric disorders. Through this narrative review, we propose a diagnostic pathway for the clinical diagnosis of a potentially autoimmune origin of psychiatric symptoms in children while considering recent guidelines.

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“…17 Table S9, http://links.lww.com/RHU/A253 summarizes the autoantibody profile reported in 9 studies. 13,17,18,[21][22][23]25,27 In the largest series, antinuclear antibodies, anti-Ro/SS antigen A (SSA), and anti-La/SS antigen B (SSB) antibodies were found in 42 (70%), 35 (58.3%), and 22 (36.7%) patients, respectively. 23 In the second largest series, anti-Ro/SSA and anti-La/SSB autoantibodies were reported in 44 (77.2%) and 46 (80.7%) patients, respectively.…”

Section: Glandular Extraglandular and Autoantibody Featuresmentioning

confidence: 99%

“…Two studies provided data on outcomes of pregnancy in women with SS. 22,28 A study from Tunisia reported on susceptibility factors of neonatal lupus in a neonate born to a mother affected by SS, with both anti-Ro/SSA and anti-La/SSB antibodies. It is notable that this mother had previously lost 2 infants due to unexplained grade III congenital heart block and had a healthy living infant with positive anti-Ro/SSA antibodies.…”

Section: Outcomes Of Pregnancy In Women With Ssmentioning

confidence: 99%

“…It is notable that this mother had previously lost 2 infants due to unexplained grade III congenital heart block and had a healthy living infant with positive anti-Ro/SSA antibodies. 22 In a crosssectional study from Gabon reporting on outcomes of pregnancy in 24 women with connective tissue diseases, 3 of them with SS, had singleton pregnancies. At conception, SS was inactive, and their ages were 23, 29, and 39 years.…”

Section: Outcomes Of Pregnancy In Women With Ssmentioning

confidence: 99%

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Epidemiology of Sjögren Syndrome in Africa

et al. 2022

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Background:The epidemiology of Sjögren syndrome (SS) has been extensively studied in America, Europe, and Asia.Objective: To summarize available data on the epidemiology of SS in Africa. Methods: MEDLINE, EMBASE, and African Journals Online were searched from inception up to May 17, 2020, to identify relevant articles. Data gleaned from these reports have been summarized narratively in this review.Results: Twenty-one hospital-based studies were included. These studies reported 744 cases of SS. The mean age at diagnosis varied between 28 and 73.6 years, and the female proportion ranged from 83.3% to 100%. There was no population-based incidence or prevalence. Among people with autoimmune and other rheumatic conditions, the frequency of primary SS was in the range 1.9% to 47.6%, whereas that of rheumatoid arthritisassociated secondary SS was in the range 4.3% to 100%. Sicca symptoms were the commonest features, with most frequently involved organs being joints, lungs, and neurological structures. Main autoantibodies were anti-Ro/SS antigen A, anti-La/SS antigen B, and antinuclear antibodies. Conclusions:The epidemiology of SS is poorly characterized in Africa.Available data are broadly consistent with those from other populations. Extensive and high-quality research is urgently needed.

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Lupus néonatal et transmission materno-fœtale des anticorps anti-SSA/Ro et anti-SSB/La

Cited by 4 publications

References 19 publications

Pregnancy Outcomes in Chinese Patients with Systemic Lupus Erythematosus (SLE): A Retrospective Study of 109 Pregnancies

Pregnancy Outcomes in Chinese Patients with Systemic Lupus Erythematosus (SLE): A Retrospective Study of 109 Pregnancies

Autoantibody-associated psychiatric syndromes in children: link to adult psychiatry

Epidemiology of Sjögren Syndrome in Africa

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