Lupus Erythematosus Panniculitis in Children: Report of Three Cases and Review of Previously Reported Cases

Weingartner, Joshua S.; Zedek, Daniel C.; Burkhart, Craig N.; Morrell, Dean S.

doi:10.1111/j.1525-1470.2011.01544.x

Cited by 28 publications

(50 citation statements)

References 21 publications

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“…The disorder is characterized by a lymphocytic infiltrate and predominately lobular panniculitis without vasculitic changes and presents as deep tender lesions with subcutaneous adipose tissue inflammation . As other groups report, and as is demonstrated in our case, the lesions of lupus profundus tend to have a facial distribution . Common histologic findings include mucin deposition in the dermis, lymphoid follicles in the subcutaneous tissue, hyaline degeneration of fat, and plasma cell inflammatory infiltrate .…”

Section: Discussionsupporting

confidence: 78%

Erythema, Atrophy, and Scarring on the Face and Arm of a Young Girl

Fang

Franco

2015

Pediatric Dermatology

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Section: Discussionsupporting

confidence: 78%

Erythema, Atrophy, and Scarring on the Face and Arm of a Young Girl

Fang

Franco

2015

Pediatric Dermatology

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“…Other forms of CCLE are rare in children, such as lupus panniculitis and lupus profundus [33, 36], mucosal LE and chilblain LE [37–40], and tumid LE [41–43]. Lupus erythematosus/lichen planus overlap syndrome has been only reported in adults [44, 45].…”

Section: Reviewmentioning

confidence: 99%

Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature

et al. 2015

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Patients diagnosed with juvenile-onset systemic lupus erythematosus (JSLE) often have skin and oral lesions as part of their presentation. These mucocutaneous lesions, as defined by the American College of Rheumatology (ACR) in 1997, include malar rash, discoid rash, photosensitivity and oral ulcers. It is therefore essential to recognize mucocutaneous lesions to accurately diagnose JSLE. The mucocutaneous lesions can be divided into those with classical histological features (LE specific) and those strongly associated with and forming part of the diagnostic spectrum, but without the classical histological changes of lupus (LE nonspecific). A malar rash is the most commonly associated LE specific dermatological presentation. This skin manifestation is an acute form and also correlates with disease activity. Subacute (polycyclic or papulosquamous lesions) and chronic (discoid lesions) forms, whilst showing classical histological changes supportive of lupus, are less commonly associated with systemic lupus and do not correlate with disease activity. The most commonly associated skin lesions without classical lupus changes are cutaneous vasculitis, oral ulcers and diffuse non-scarring alopecia. These signs frequently relate to disease activity. An understanding of cutaneous signs and symptoms of lupus in children is important to avoid delay in diagnosis. They will often improve as lupus is adequately controlled and their reappearance is often the first indicator of a disease flare.

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“…44 CD20 will highlight small clusters or scattered B cells. 46,50 Ki-67 (MIB-1) may assess the degree of constituent lymphocyte proliferation, with higher rates (often exceeding >50% of cells) considered additional evidence for lymphoma. 51 Molecular studies may be employed to discern tumor cell clonality; however, LEP cases may exhibit clonal lymphoid populations in a minority of cases, and this result should be interpreted with caution.…”

Section: Lupus-associated Panniculitismentioning

confidence: 99%

Mimics of Cutaneous Lymphoma

Sarantopoulos

Palla

Said

et al. 2013

American Journal of Clinical Pathology

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The Society for Hematopathology and European Association for Haematopathology workshop, from October 27 to 29, 2011, in Los Angeles, CA, exhibited many exemplary skin biopsy specimens with interesting inflammatory changes mimicking features of cutaneous lymphoma. This article reviews features observed in cutaneous lymphoid hyperplasia, cutaneous drug reactions, lupus-associated panniculitis, pityriasis lichenoides, hypereosinophilic syndrome, histiocytic necrotizing lymphadenitis, traumatic ulcerative granuloma with stromal eosinophils, and pigmented purpuric dermatosis, as well as a brief review of the pertinent literature and discussion of submitted conference cases. For the pathologist, it is important to be aware of diagnostic pitfalls as well as the limitations of ancillary testing (eg, clonality studies). Finally, correlation with total clinical information, good communication with clinical colleagues, close clinical follow-up with rebiopsy, and prudent use of laboratory studies are vital and will likely offer the best path toward a correct diagnosis.

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Lupus Erythematosus Panniculitis in Children: Report of Three Cases and Review of Previously Reported Cases

Cited by 28 publications

References 21 publications

Erythema, Atrophy, and Scarring on the Face and Arm of a Young Girl

Erythema, Atrophy, and Scarring on the Face and Arm of a Young Girl

Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature

Mimics of Cutaneous Lymphoma

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