Lupus erythematosus induced by medications, ultraviolet radiation, and other exogenous agents: A review, with special focus on the development of subacute cutaneous lupus erythematosus in a genetically predisposed individual

Shapiro, Michael B.; Sosis, Arthur C; Junkins‐Hopkins, Jacqueline M.; Werth, Victoria P.

doi:10.1111/j.1365-4632.2004.02013.x

Cited by 29 publications

(12 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reasons for this are multiple and include all of the following: the interaction of genetic and environmental factors [1][2][3], the potential role of stochastic factors [1,4], the polygenic nature of inherited susceptibility to autoimmunity [1,2,5], the existence of distinct checkpoints or stages in the development of autoimmunity, each of which may require the contribution of separate genes [1,2], and finally, the possibility that diseases such as systemic lupus erythematosus (SLE) may, like cancer, be more a syndrome than a single entity and represent a common phenotype arising from multiple, distinct causes [1,5,6]. Given this inordinate complexity, the existence of common cellular abnormalities, which are shared by all or many of the major models of spontaneous autoimmunity, may provide invaluable clues to the pathogenesis of autoimmunity.…”

Section: Introductionmentioning

confidence: 99%

Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity

Fan

Patel

Longacre

et al. 2005

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Macrophages (mphi) from prediseased mice of all the major murine models of spontaneous autoimmunity have an identical defect in cytokine expression that is triggered by serum and/or apoptotic cells. We show here that mphi from prediseased mice of the same models of spontaneous autoimmunity share a serum-dependent defect in the activity of Rho, a cytoplasmic G protein and cytoskeletal regulator. Affected strains include those developing lupus (BXSB, LG, MRL/l+, MRL/lpr, NZBWF1) and autoimmune diabetes (nonobese diabetic). No similar defect in Rho activity occurred in seven control strains. In the presence of serum, Rho activity in mphi from all autoimmune-prone strains was reduced to less than 10% of that in control mice. In contrast, under serum-free conditions, Rho activity was completely normal in autoimmune-prone mphi. The activities of Ras, another cytoplasmic G protein, and Rac and Cdc42, two additional G protein regulators of the cytoskeleton, were regulated normally in autoimmune-prone strains. Serum-dependent dysregulation of Rho was associated with multiple abnormalities, including increased adhesion to various surfaces, a more spread dendritic morphology, and an altered actin cytoskeletal organization. Our results suggest that mphi from multiple, genetically diverse, autoimmune-prone strains share a mutation or allelic difference affecting signal transduction within a specific Rho-regulatory pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity

Fan

Patel

Longacre

et al. 2005

Journal of Leukocyte Biology

View full text Add to dashboard Cite

show abstract

“…3 The trigger for the onset of the disease may be trauma, primary irritation or exogenous agents such as ultraviolet light, drugs, pesticides, heavy metals or other elements. 2,14 The apoptosis of keratinocytes has been indicated as a key event in triggering cutaneous lupus lesions through various apoptotic pathways such as p53, tumor necrosis factor-alpha (TNF-α) and Fas/FasL. 5,15 It is speculated that the aberrant keratinocytes may be unable to express the essential proteins required to regulate apoptosis, and are hence unable to prevent the apoptosis induced by solar radiation, for example.…”

Section: Discussionmentioning

confidence: 99%

Lúpus eritematoso crônico discoide nas linhas de Blaschko

Daldon

Lage

2011

An. Bras. Dermatol.

View full text Add to dashboard Cite

Linear chronic discoid lupus erythematosus is a rare manifestation of cutaneous lupus in which erythematous, atrophic, dyschromic lesions are located along the lines of Blaschko. This report describes the case of a 15-year old boy with a 2-year history of discoid, erythematous, hyper and hypopigmented lesions with central atrophy, situated along the lines of Blaschko on his right arm. Histopathology showed epidermal atrophy, hyperkeratosis, follicular plugging, thickening of the basement membrane zone, and superficial and deep chronic perivascular and periadnexal inflammatory infiltrate, with dermal mucin deposit, thus confirming diagnosis. A total of 14 cases have been described of this variant, the onset of which is often in childhood. There is no difference in incidence between genders. Lesions most commonly develop on the face. There have been no reports of any association with systemic disease. Keywords: Lupus erythematosus, cutaneous; Lupus erythematosus, discoid; Mosaicism Resumo: O lúpus eritematoso crônico discoide linear é manifestação rara da doença lúpica cutânea, em que lesões eritêmato-atrófico-discrômicas dispõem-se nas linhas de Blaschko. Descrevemos o caso de um menino de 15 anos, com dois anos de história de lesões discoides eritêmato-atróficas, hipo e hiperpigmentadas, dispostas nas linhas de Blaschko do membro superior direito. O exame histopatológico revelou atrofia da epiderme, hiperqueratose, rolhas córneas, espessamento da zona da membrana basal, infiltrado inflamatório crônico perianexial e perivascular superficial e profundo, depósito de mucina na derme, confirmando o diagnóstico. Há, no total, 14 casos descritos dessa variante que se inicia frequentemente na infância e que não apresenta predomínio quanto ao sexo. As lesões ocorrem preferencialmente na face. Não há relatos de associação com doença sistêmica. Palavras-chave: Lupus eritematoso cutâneo; Lupus eritematoso discóide; Mosaicismo

show abstract

“…About 50% of the patients fulfil at least 4 of the ACR-criteria, and these patients commonly have high titers of anti-SSA or anti-SSB [33]. Drug-induced SCLE is not infrequent [34]. Considerable histological overlap exist between DLE and SCLE, and differentiation between them cannot be established from the histological picture alone [35].…”

Section: Subsets Of Lupus Dermatitis -Meaningful In Context Of New Inmentioning

confidence: 98%

Pathogenesis of SLE Dermatitis - A Reflection of the Process in SLE Nephritis?

Fismen¹,

Rekvig²,

Mortensen

2007

CRR

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is an inflammatory autoimmune syndrome that may affect most organs in the body. Anti-dsDNA antibodies represent a classification criterion for SLE and are involved in lupus nephritis. Recently, the structures that bind lupus-related nephritogenic autoantibodies in vivo have been characterized by transmission electron microscopy (EM), immune-EM and co-localization immune-EM. By these methods, glomerular in vivo-bound autoantibodies were shown to co-localize with loci for binding of different experimental anti-chromatin antibodies, pointing at glomerular basement membrane-associated nucleosomes as target antigens. Lupus dermatitis has not been investigated in as much detail as lupus nephritis, but data indicate similarities between these two organ manifestations. The presence of granular antibody deposits at the dermo-epidermal junction suggests that the tissue injury is mediated by immune complexes. The deposits may be constituted by nucleosomes or chromatin and antibodies bound to them. The nucleosomes may be released locally or systemically from apoptotic cells; i.e. a process similar to that established for lupus nephritis. In this review we summarize current knowledge on immuno-pathological processes that are central in lupus nephritis, and discuss whether they may be similar to those occurring in lupus dermatitis.

show abstract

Lupus erythematosus induced by medications, ultraviolet radiation, and other exogenous agents: A review, with special focus on the development of subacute cutaneous lupus erythematosus in a genetically predisposed individual

Cited by 29 publications

References 92 publications

Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity

Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity

Lúpus eritematoso crônico discoide nas linhas de Blaschko

Pathogenesis of SLE Dermatitis - A Reflection of the Process in SLE Nephritis?

Contact Info

Product

Resources

About