Lupus érythémateux systémique se présentant comme un syndrome de Stevens-Johnson

Bellakhal, S.; Kaab, B. Ben; Teyeb, Z.; Souissi, Amel; Derbel, F.; Douggui, M.H.

doi:10.1016/j.patbio.2015.05.001

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…1,8,11,12 Unfortunately, there is no consensus regarding treatment as there are so few cases reported. 11,13,14 Systemic corticosteroids have been shown to be effective but also associated with resistance in several patients. 13 In a review of 43 cases of TEN-like acute cutaneous lupus erythematosus (ACLE), Romero et al 8 describe combination of systemic corticosteroids with hydroxychloroquine (8 cases), intravenous immunoglobulin (10 cases) and mycophenolate mofetil (4 cases), resulting in clinical resolution.…”

Section: Discussionmentioning

confidence: 99%

“…While classic TEN is associated with a high morbidity and mortality, TEN-like LE has been associated with a low mortality in the treated cases reported. 1 , 8 , 11 , 12 Unfortunately, there is no consensus regarding treatment as there are so few cases reported. 11 , 13 , 14 Systemic corticosteroids have been shown to be effective but also associated with resistance in several patients.…”

Section: Discussionmentioning

confidence: 99%

“…In conclusion, this is one of few reported cases of TEN-like skin eruption occurring as the first manifestation of SLE. 1 , 8 , 9 , 11 – 15 TEN-like dermatoses should be included in the differential of acute sheet-like epidermal detachment, especially in the absence of mucosal involvement, high-risk drug ingestion and hemodynamic instability. Positive autoimmune serology may further support the diagnosis of TEN-like LE.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A case of toxic epidermal necrosis–like cutaneous eruption as the first manifestation and clue to the diagnosis of systemic lupus erythematosus: A case report

Zargham

Ghazal

Watters

et al. 2020

SAGE Open Medical Case Reports

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We present a rare case of a 61-year-old woman presenting with a widespread erosive eruption on her torso and extremities. Although the lesions were histologically compatible with toxic epidermal necrolysis, clinically the patient was hemodynamically stable, had no mucosal involvement and had no relevant medical history or potentially incriminating medications. Further investigations uncovered a new diagnosis of systemic lupus erythematosus, with this toxic epidermal necrolysis–like eruption being the first presentation of the disease. This case highlights the importance of broadening the differential diagnosis in patients presenting with acute widespread cleavage of the epidermis, using the spectrum of acute syndrome of apoptotic pan-epidermolysis as a reference.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A case of toxic epidermal necrosis–like cutaneous eruption as the first manifestation and clue to the diagnosis of systemic lupus erythematosus: A case report

Zargham

Ghazal

Watters

et al. 2020

SAGE Open Medical Case Reports

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Antikörper korrelieren mit der klinischen Aktivität

Sticherling¹

2016

Dtsch Dermatolog

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Morbidity and Mortality of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in United States Adults

Hsu

Brieva

Silverberg

et al. 2016

Journal of Investigative Dermatology

262

226

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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening disorders. Our study objective was to describe the incidence, costs of care, length of stay, comorbidities, and mortality of SJS and TEN in US adults. The Nationwide Inpatient Sample 2009-2012, containing a 20% sample of all US hospitalizations, was analyzed. We used a validated approach involving International Classification of Disease, 9th edition, Clinical Modification codes to identify SJS, SJS/TEN, and TEN (n = 2,591, n = 502, and n = 564, respectively). The mean estimated incidences of SJS, SJS/TEN, and TEN were 9.2, 1.6, and 1.9 per million adults per year, respectively. SJS/TEN was associated with nonwhite race, particularly Asians (odds ratio = 3.27, 95% confidence interval = 3.02-3.54) and blacks (odds ratio = 2.01, 95% confidence interval = 1.92-2.10). Significantly prolonged length of stay and higher costs of care (SJS: 9.8 ± 0.3 days, $21,437 ± $807; SJS/TEN: 16.5 ± 1.0 days, $58,954 ± $5,238; TEN: 16.2 ± 1.0 days, $53,695 ± $4,037) were observed compared with all other admissions (4.7 ± 0.02 days, $11,281 ± $98). Mean adjusted mortality was 4.8% for SJS, 19.4% for SJS/TEN, and 14.8% for TEN. SJS, SJS/TEN, and TEN pose a substantial health care burden. Predictors of mortality included increasing age, increasing number of chronic conditions, infection (septicemia, pneumonia, tuberculosis), hematological malignancy (non-Hodgkin's lymphoma, leukemia), and renal failure (P ≤ 0.03 for all). Further studies are needed to confirm mortality findings to improve prognostication of SJS/TEN.

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Lupus érythémateux systémique se présentant comme un syndrome de Stevens-Johnson

Cited by 3 publications

References 8 publications

A case of toxic epidermal necrosis–like cutaneous eruption as the first manifestation and clue to the diagnosis of systemic lupus erythematosus: A case report

A case of toxic epidermal necrosis–like cutaneous eruption as the first manifestation and clue to the diagnosis of systemic lupus erythematosus: A case report

Antikörper korrelieren mit der klinischen Aktivität

Morbidity and Mortality of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in United States Adults

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