Lupus érythémateux systémique : mortalité et facteurs de mauvais pronostic dans une série marocaine de 129 cas

Bouras, M.; Hali, F.; Khadir, K.; Benchikhi, H.

doi:10.1016/j.annder.2013.10.049

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…SLE can be found at any age, the age of onset of the disease in men is identical to that of women in our series and several international studies 14,15,16,17,18,19 . An average younger age is found in Saudi Arabia 24.4 years 20 , Lebanon 25 years 21 , 25.8 years in Egypt 22 , and significantly higher in American 11 and Japanese 23 series.…”

Section: Discussionsupporting

confidence: 85%

Systemic Lupus Erythematosus in Algerian Men: Clinical-Biological and Evolutionary Analysis of 19 Algerian Men

Belmokhtar

Zemri

Kanoun

et al. 2020

J. Drug Delivery Ther.

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Objectives: the aim of our study was to precise the epidemiological, clinicobiological, immunological, and evolutionary profile of systemic lupus erythematosus in Algerian men. Methods: A retrospective multicenter study was carried out on 19 Algerian male lupus patients, diagnosed according to the ACR and SLICC criteria and followed between 2006 and 2019 on a total of 203 cases of systemic lupus erythematosus in western Algeria. Results: 203 SLE patients were included, 19 men (9.4%) and 184 women (90.6%) with F/ M sex ratio of 9.68 / 1. The mean age at diagnosis was 33 ± 9.49 years. The most frequent clinical manifestations were joint involvement (84.2%), cutaneous (68.4%) and hematological disorder (63.2%). 15.8% had lupus nephropathies with the predominance of class IV; Raynaud's syndrome and neuropsychiatric involvement were found in 26.3%. Comparison of these results with those of 184 lupus women showed a significant frequency of mucosal ulcer (p=0.000011) and neuropsychiatric damage in men (p=0.011), while alopecia in women (p=0.021). As well, hypocomplementemia (p=0.0004), anti-Sm antibodies (p=0.053) and anti Ribosome (p=0.028) were more frequent in men; while anti-SSA (p=0.003) and anti-SSB (p=0.011) antibodies were more frequent in women. Survival of lupus men was equal to 100% throughout the studied period. Conclusion: Male lupus is rare. The Algerian man suffers from SLE in a less severe form compared to other data in the literature, which is manifested by a lower frequency of organ damage and mortality. Keywords: Male lupus, epidemiology, clinical polymorphism, evolutionary profile, western Algeria.

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Section: Discussionsupporting

confidence: 85%

Systemic Lupus Erythematosus in Algerian Men: Clinical-Biological and Evolutionary Analysis of 19 Algerian Men

Belmokhtar

Zemri

Kanoun

et al. 2020

J. Drug Delivery Ther.

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“…Infectious complications were also significantly associated with death in our cohort. The same was true for Mu et al [28] in China (p = 0.000; OR = 4.25), Rabbani et al [29] in Pakistan (p = 0.004), Bouras et al [24] in Morocco (p = 0.026). Several studies have demonstrated that corticosteroids, especially at daily doses in excess of 20 mg, are responsible for increasing the risk of infection.…”

Section: Discussionsupporting

confidence: 57%

“…The association between renal involvement and death found in our study is in agreement with most authors who confirm that renal involvement is a poor prognostic factor in SLE. This is the case for Meunier et al [22] in France (p < 0.001; OR = 3.29), Wang et al [23] in China (p = 0.032; OR = 3.1); Bouras et al [24] in Morocco (p = 0.027) and Wadee et al [25] in South Africa (p = 0.002). Indeed, the prognosis of lupus patients is strongly influenced by the existence or absence of nephropathy secondary to lupus.…”

Section: Discussionmentioning

confidence: 77%

Clinical Presentation and Evolution of Systemic Lupus at the CNHU-HKM of Cotonou (Benin)

Anthelme,

Armand,

Abdul-Farid

et al. 2023

OJIM

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Introduction: Systemic lupus erythematosus (SLE) is a non-organ-specific autoimmune disease with an unknown origin. The unchanged trend of premature mortality in systemic lupus erythematosus shows the critical unmet need for improved and optimized management of systemic lupus erythematosus. Objectives: To analyze the clinical features and the prognostic factors of death in SLE at the CNHU-HKM of Cotonou. Patients and Methods: This was a retrospective cohort study. It was conducted over the period from January 1st 2010 to December 31st 2021. The study population consisted of all patients followed for SLE in the internal medicine, rheumatology, nephrology and dermatology wards at the CNHU-HKM of Cotonou. Results: 88 cases were recorded in 12 years, i.e. an incidence of 7 cases per year. There were 80 women and 8 men with a mean age of 36.4 ± 13.1 years. The clinical picture was dominated by mucocutaneous (86.3%) and osteoarticular (71.5%) disorders. The biological abnormalities observed were anemia (78.8%), lymphopenia (43.1%) and thrombocytopenia (17.7%). 39 patients had renal damage (44.3%). The incidence of death was 17%. Factors associated with death were renal involvement, infectious complications, high initial SLEDAI score, flare, thrombocytopenia and lymphopenia. Conclusion: Mortality related to SLE remains high at the CNHU-HKM of Cotonou. Renal involvement, infectious complications, high initial SLEDAI score, flare, lymphopenia and thrombocytopenia were the factors associated with death. The presence of these factors should lead to an evaluation of the treatment.

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“…Cette atteinte conditionne le pronostic fonctionnel mais aussi vital de la maladie. Il s'agit d'un facteur pronostique statistiquement significatif de mortalité dans une série marocaine de 129 patients, ce qui est d'ailleurs en accord avec les données de la littérature [ 4 ]. Ceci a justifié une étude détaillée du profil des auto-anticorps chez les patients lupiques ayant une atteinte rénale dans notre série.…”

Section: Discussionunclassified

Lupus systémique et atteinte rénale: apport des anticorps anti-SSA

Baline¹,

Zaher²,

Fellah³

et al. 2015

Pan Afr Med J

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Le but de notre travail est de déterminer le profil des auto-anticorps chez 30 patients ayant un lupus systémique avec ou sans atteinte rénale afin d’établir une corrélation clinico-immunologique entre la néphropathie lupique et ces auto-anticorps. Il s'agit d'une étude transversale de 30 patients atteints de lupus érythémateux systémique diagnostiqués au service de dermatologie durant la période de Décembre 2010 à Décembre 2012 et réalisée conjointement avec le laboratoire d'immunologie. Les anticorps anti-ADN étaient retrouvés chez 17 patients (56.7%) suivis des anti-SSA dans 12 cas (40%). Cinq patients (62.5%) ayant une atteinte rénale avaient des anticorps anti DNA négatifs. Parmi ces patients avec atteinte rénale, 37.5% avaient des anticorps anti SSA sans anticorps anti DNA. La moitié des patients ayant une atteinte rénale (50%) avaient des anticorps anti SSA positifs. Notre série montre l'importance des anticorps anti-SSA surtout chez des patients avec des anticorps anti-DNA négatifs non seulement pour le diagnostic du lupus systémique mais aussi pour déceler certaines manifestations systémiques comme l'atteinte rénale.

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Lupus érythémateux systémique : mortalité et facteurs de mauvais pronostic dans une série marocaine de 129 cas

Cited by 3 publications

References 7 publications

Systemic Lupus Erythematosus in Algerian Men: Clinical-Biological and Evolutionary Analysis of 19 Algerian Men

Systemic Lupus Erythematosus in Algerian Men: Clinical-Biological and Evolutionary Analysis of 19 Algerian Men

Clinical Presentation and Evolution of Systemic Lupus at the CNHU-HKM of Cotonou (Benin)

Lupus systémique et atteinte rénale: apport des anticorps anti-SSA

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