Lupus eritematoso sistémico y púrpura trombótica trombocitopénica: un caso refractario sin actividad lúpica asociada

Multidisciplinary team approach for an atypical presentation of postpartum thrombotic thrombocytopenic purpura and severe preeclampsia in the Intensive Care Unit

“…The authors also highlight the importance of early introduction of PLEX therapy since early initiation of PLEX in patients with TTP has been shown to decrease mortality to <20%, and a delay in diagnosis may result in devastating consequences. [ 8 ] Finally, our case exemplifies that even with the gold standard therapy for TTP (PLEX), patients may require further escalation of care with immunomodulation (rituximab and vincristine) to assure the best possible outcome,[ 7 8 ] as well as emphasizing timely utilization of appropriate hospital resources is paramount in the management of similar life-threatening clinical conditions.…”

“…[ 6 7 8 ] Furthermore, this study showed that idiopathic cases of TTP with severe deficiency of ADAMTS13 (<10%) were younger and had lower platelet counts upon diagnosis, an elevated risk of renal involvement, required additional PLEX sessions, and had a higher recurrence risk. [ 7 8 ]…”