Lupus eritematoso sistêmico: novo fator de risco para aterosclerose?

Abstract

OBJECTIVETo evaluate the prevalence of cardiovascular events (CVE) secondary to atherosclerosis in lupus patients and correlate them to the traditional risk factors, disease duration and drug therapy used. METHODSA retrospective study was carried out based on data obtained from patients' charts. Patients included were those who had a lupus diagnosis confirmed at least two years before inclusion in the study and had been followed since 1992. CVE were characterized as MI, angina pectoris and stroke non-related to lupus activity. Risk factors and drugs used for treatment were recorded. RESULTSSeventy-one charts were analyzed. Patients' mean age was 34.2±12.7 years; 68 were women and three were men; 58 were Caucasian (81.6%). Ten (14.08%) presented CVE. Patients in whom CVE were observed were older (42.7 vs. 32.8 years p=0.0021) and presented longer disease duration (10.8 vs. 7.2 years p=0.011). The traditional risk factors, daily and cumulative doses of steroids, immunosuppressive drugs and antimalarial drugs were not significant when patients with and without CVE were compared. CONCLUSIONThe prevalence of CVE secondary to atherosclerosis in systemic lupus erythematosus (SLE) was 14.08%. The traditional risk factors were not associated with the development of CVE in lupus patients. Patients that presented cardiovascular events were older and presented longer disease duration. It is a premature conclusion to establish SLE as an independent risk factor for atherosclerosis development. KEY WORDSSystemic lupus erythematosus, atherosclerosis, cardiovascular disease.

Avaliação do polimorfismo genético pvuII do receptor de lipoproteína de baixa densidade (RLDL) em pacientes com lúpus eritematoso sistêmico

“…As características demográficas dos pacientes com LES estão de acordo com os descritos previamente na literatura, em que há um predomínio de LES em indivíduos do sexo feminino, caucasianos e com surgimento da doença na idade reprodutiva (FREIRE et al, 2006;WIJAYA et al, 2005).…”

Inadequate dietary intake of children and adolescents with juvenile idiopathic arthritis and systemic lupus erythematosus

“…Com a melhora da sobrevida, eventos antes não tão frequentes agora fazem parte da evolução da doença 6,7 . Assim, complicações crônicas relacionadas ao LES juvenil, aos hábitos alimentares e ao estilo de vida inadequados, como aterosclerose, obesidade e osteoporose, podem comprometer o prognóstico dos pacientes e precisam ser prevenidas 8 .…”

Traditional Chinese Medicine Decreases the Stroke Risk of Systemic Corticosteroid Treatment in Dermatitis: A Nationwide Population-Based Study

“…It is believed that this treatment is atherogenic for the long-term used, partially due to effects on plasma lipoproteins, elevation of total cholesterol and triglycerides and for promoting an abnormal distribution of high-density lipoprotein subclasses [ 9 ]. The systemic corticosteroid can also indirectly accelerate the process by augmenting other traditional risk factors, including hypertension and obesity [ 10 ]. On the other hand, inflammation is associated with atherosclerosis, and therefore corticosteroid therapy could have a protective effect.…”