Lupus eritematoso neonatal: revisión de casos en los últimos 5 años

Chacón, Rocío Porcel; Ceballos, L. Tapia; Cabrera, Rocío Díaz; Perandones, María Teresa Gutiérrez

doi:10.1016/j.reuma.2013.10.005

Cited by 8 publications

(1 citation statement)

References 6 publications

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“…While there remain no reported cases of newborn anti-GBM disease, this provides only some reassurance given only six described live births from mothers with de novo anti-GBM disease in pregnancy (Table 3 ). Moreover, transplacental antibody transmission has been linked to neonatal pulmonary-renal syndrome from myeloperoxidase-ANCA antibodies [ 52 , 53 ], and neonatal lupus erythematosus from a variety of lupus antibodies [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Maternal, pregnancy and fetal outcomes in de novo anti-glomerular basement membrane antibody disease in pregnancy: a systematic review

Thomson

Joseph

Clark

et al. 2014

Clinical Kidney Journal

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BackgroundOutside of pregnancy, anti-glomerular basement membrane (GBM) antibody disease is associated with significant morbidity and mortality. However, there is limited knowledge regarding de novo anti-GBM disease in pregnancy.MethodsA systematic review was performed to identify maternal, pregnancy and fetal outcomes in de novo anti-GBM disease in pregnancy. Studies were selected from PubMed, EMBASE, Cochrane Library databases and conference proceedings, without language restriction.ResultsData from eight patients were derived from seven case reports and one unpublished case. Most (6/8) patients presented after the first trimester. During pregnancy, acute kidney injury (5/8), anemia (5/8), hematuria (8/8) and proteinuria (8/8) were common. When hemodialysis was required antepartum (5/8), renal function recovery to independence of renal replacement was unlikely (2/5). While pulmonary involvement was common (5/8), no permanent damage was reported (0/8). The majority of cases ended in live births (6/8) although prematurity (6/6), intrauterine growth restriction (2/6), small for gestational age (4/6) and complications of prematurity (1/6) were common. When anti-GBM levels were tested in the living newborn, they were detectable (2/5), but no newborn renal or lung disease was reported (0/6). Complications in pregnancy included gestational diabetes (3/8), hyperemesis gravidarum (2/8) and preeclampsia (2/8).ConclusionsLive births can be achieved in de novo anti-GBM disease in pregnancy, but are commonly associated with adverse maternal, pregnancy and fetal outcomes. Only with awareness of common presentations, and management strategies can outcomes be optimized.

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Section: Discussionmentioning

confidence: 99%

Maternal, pregnancy and fetal outcomes in de novo anti-glomerular basement membrane antibody disease in pregnancy: a systematic review

Thomson

Joseph

Clark

et al. 2014

Clinical Kidney Journal

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Dermatoses of the Neonate

Paige

2016

Rook's Textbook of Dermatology, Ninth Edition

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Rashes in the first 4 weeks of life are common and can be alarming for both parents and medical staff. Many of these are entirely innocent and resolve spontaneously and reassurance of the parents is all that is required. It is important to be aware of such ‘benign’ rashes (as well as the appearance of preterm and post‐term skin) when assessing genuine pathology in the neonate. Pathological dermatoses may arise by a number of different mechanisms. Iatrogenic causes (medical procedures) can cause rashes/lesions both in utero and in the neonatal period. Transplacental transfer of antibodies, infection or malignant cells from mother to child is another mechanism for causing neonatal rashes. Infection can also be passed on from attendant medical staff. Finally, primary dermatoses may present early in the neonatal period, especially genodermatoses such as collodion baby and epidermolysis bullosa.

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Dermatoses of the Neonate

Clayton,

Sharif

2024

Rook's Textbook of Dermatology

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This chapter provides an overview of neonatal skin function and intrauterine skin development. The impact on the skin of gestational age at birth is discussed along with cutaneous complications arising from prematurity and neonatal medical procedures. Skin care practices and considerations for neonates are summarised and physiological appearances and changes are described. On overview of disordered skin in neonates is provided, including pustular eruptions, atrophic skin lesions, disorders of neonatal fat, colloidion baby, blueberry muffin baby, purpura fulminans and common neonatal dermatosis. The clinical manifestions in a neonate of transplacental transfer of maternal autoantibodies is evaluated, including in conditions such as pemphigus vulgaris, pemphigus foliaceus, herpes gestationis, lupus erythematosus and maternal malignancy. Finally, on overview of infective skin pathologies and clinical manifestations in neonates is provided including viral, bacterial and fungal pathogens.

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Lupus eritematoso neonatal: revisión de casos en los últimos 5 años

Cited by 8 publications

References 6 publications

Maternal, pregnancy and fetal outcomes in de novo anti-glomerular basement membrane antibody disease in pregnancy: a systematic review

Maternal, pregnancy and fetal outcomes in de novo anti-glomerular basement membrane antibody disease in pregnancy: a systematic review

Dermatoses of the Neonate

Dermatoses of the Neonate

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