Lupus Cohorts

Redmond, Christopher; Pamuk, Ömer Nurı

doi:10.1016/j.rdc.2021.04.009

Cited by 3 publications

(2 citation statements)

References 86 publications

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“…SLE is more common among Asian, African American, African Caribbean, and Hispanic American populations than among White Americans. While Asian, African American, African Caribbean, and Hispanic American populations have a higher prevalence of SLE than White Americans, the LUMINA and Maryland Lupus [10] cohorts found a higher prevalence of NPSLE among White Americans. NPSLE is also associated with older age, likely because of comorbidities, such as CVD, hypertension, and diabetes [11].…”

Section: Epidemiologymentioning

confidence: 94%

Neuropsychiatric Systemic Lupus Erythematosus: Antibodies Involved, Clinical Characteristics and Treatment

Gopaul,

Vaillant

2023

Preprint

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Systemic lupus erythematosus (SLE) is a chronic idiopathic autoimmune disease affecting various organs. Patients with SLE also present numerous neuropsychiatric manifestations. These neuro-psychiatric manifestations are referred to as neuropsychiatric systemic lupus erythematosus (NPSLE). Neuropsychiatric involvement in patients with SLE was first mentioned by Kaposi more than 100 years ago and is a generic term that refers to neurological and psychiatric symp-toms resulting directly from or as a complication of SLE. NPSLE affects both the CNS and PNS and can manifest as various symptoms, such as cognitive dysfunction, organic brain syndromes, delirium, seizures, headache, and psychosis. NPSLE was previously referred to as ‘lupus cerebri-tis’ or lupus sclerosis. However, these terms are no longer recommended because there is no de-finitive pathological cause for the neuropsychiatric manifestations of SLE.[2]

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Section: Epidemiologymentioning

confidence: 94%

Neuropsychiatric Systemic Lupus Erythematosus: Antibodies Involved, Clinical Characteristics and Treatment

Gopaul,

Vaillant

2023

Preprint

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“…These studies have given us the tools to predict who is at high risk for type 1 diabetes (T1D) [51,52], leading to the development of interventions to delay [53], and in the future, to find therapies that will prevent T1D. Prospective longitudinal at-risk cohorts have also been established for RA (SERA [54], SCREEN-RA [55]), SLE (SisSLE [56,57]), and Crohn's disease [58]. We need to continue to expand on this early success.…”

Section: Human Immunology Toolkit For Autoimmune Diseasesmentioning

confidence: 99%

Translational immunology: Applying fundamental discoveries to human health and autoimmune diseases

Buckner

2023

Eur J Immunol

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Studying the human immune system is challenging. These challenges stem from the complexity of the immune system itself, the heterogeneity of the immune system between individuals, and the many factors that lead to this heterogeneity including the influence of genetics, environment, and immune experience. Studies of the human immune system in the context of disease are increased in complexity as multiple combinations and variations in immune pathways can lead to a single disease. Thus, although individuals with a disease may share clinical features, the underlying disease mechanisms and resulting pathophysiology can be diverse among individuals with the same disease diagnosis. This has consequences for the treatment of diseases, as no single therapy will work for everyone, therapeutic efficacy varies among patients, and targeting a single immune pathway is rarely 100% effective. This review discusses how to address these challenges by identifying and managing the sources of variation, improving access to high‐quality, well‐curated biological samples by building cohorts, applying new technologies such as single‐cell omics and imaging technologies to interrogate samples, and bringing to bear computational expertise in conjunction with immunologists and clinicians to interpret those results. The review has a focus on autoimmune diseases, including rheumatoid arthritis, MS, systemic lupus erythematosus, and type 1 diabetes, but its recommendations are also applicable to studies of other immune‐mediated diseases.

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Profile of juvenile systemic lupus erythematosus patients with a special reference to monogenic lupus and lupus nephritis: a cross-sectional study

Bhattad,

Singh,

Janardhanan

et al. 2024

Rheumatol Int

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Lupus Cohorts

Cited by 3 publications

References 86 publications

Neuropsychiatric Systemic Lupus Erythematosus: Antibodies Involved, Clinical Characteristics and Treatment

Neuropsychiatric Systemic Lupus Erythematosus: Antibodies Involved, Clinical Characteristics and Treatment

Translational immunology: Applying fundamental discoveries to human health and autoimmune diseases

Profile of juvenile systemic lupus erythematosus patients with a special reference to monogenic lupus and lupus nephritis: a cross-sectional study

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