Lupus anticoagulants/anticardiolipin antibodies in patients with normal tension glaucoma

Da, Tsakiris; Osuský, Roman; Hj, Kaiser; Mueri, R; Ga, Marbet

doi:10.1097/00001721-199210000-00004

Cited by 12 publications

(10 citation statements)

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“…In our study, we did not find increased blood concentrations of anticardiolipin antibodies in the NTG patients. This confirms the results of studies by Tsakiris et al and the CGS [13,20]. Additionally, in the present study we did not find increased anti-beta-2-glycoprotein I antibodies in the patients with NTG.…”

Section: Discussionsupporting

confidence: 93%

“…Although the difference was statistically significant, the percentage of subjects with increased anticardiolipin antibodies (5.5% of the 258 study subjects) did not differ from that of the general population, which is 2% to 7% [10,13]. The above results are in agreement with the findings of Tsakiris et al who did not detect any significant differences in antiphospholipid antibody levels (anticardiolipin antibodies and lupus anticoagulants) between NTG and POAG patients and controls [20]. Our study included determinations of antiphospholipid antibodies in the blood.…”

Section: Discussionsupporting

confidence: 87%

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Selected autoantibodies and normal-tension glaucoma

Jamrozy−Witkowska

2014

Med Sci Monit

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BackgroundAlthough intraocular pressure is an important risk factor in glaucoma, there is growing body evidence indicating an immunological component in the pathogenesis of normal-tension glaucoma (NTG). The aim of this study was to determine if NTG coexists with elevated levels of autoantibodies detected in rheumatic diseases.Material/MethodsWe enrolled 105 patients into the study: 35 with NTG, 34 with primary open-angle glaucoma (POAG), and 36 controls. All patients underwent ophthalmic examination and blood tests. Blood was examined for the level of: antibodies against antinuclear antibodies (ANA), antibodies to extractable nuclear antigens (ENA), immunoglobulins (IgG, IgA, IgM), rheumatoid factor, anti-citrullinated protein antibodies (ACPA), and antiphospholipid antibodies (anticardiolipin antibodies, beta2-glycoprotein I antibodies, antiprothrombin antibodies).ResultsThe level of ANA was increased among 6 patients in the NTG group (17.1%), 8 in the POAG group (23.5%), and 6 in the control group (16.5%). The difference was not statistically significant (p=0.97). None of the patients in the NTG, POAG, or control group had positive antibodies to ENA. The level of immunoglobulins IgG, IgM, and IgA in the 3 groups was similar and within normal values. The median level of rheumatoid factor and ACPA was the highest in the NTG group, but it was within normal laboratory values. There was a statistically significant difference between antiprothrombin antibodies IgG between the NTG and POAG group (p=0.01), but not between the NTG and control group (p=0.24).ConclusionsThe results of our study do not confirm the hypothesis that NTG coexists with elevated blood levels of antibodies, which are a characteristic feature of rheumatic diseases.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 87%

Selected autoantibodies and normal-tension glaucoma

Jamrozy−Witkowska

2014

Med Sci Monit

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“…1 2 These "vascular factors" could be organic, vasospastic, 3 or combinations of these. Risk factors that have been investigated in NTG include large vessel disease, 4 hypertension, 5 hypotension and shock, 6 diabetes mellitus, 7 increased blood lipids, 8 abnormal blood coagulation, [9][10][11] anticardiolipin antibodies and other haemostatic factors, including von Willebrand factor, 12 perfusion pressure in ophthalmic artery, 13 and peripheral vascular endothelial dysfunction, as assessed by forearm blood flow responses to intra-arterial infusions of vasoactive agents. 3 However, none of these factors separately has been established to have a strong correlation with NTG.…”

mentioning

confidence: 99%

Plasma vascular endothelial growth factor, soluble VEGF receptor FLT-1, and von Willebrand factor in glaucoma

Lip

Felmeden

Blann

et al. 2002

British Journal of Ophthalmology

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“…Tsakiris et al observed a higher prevalence of positive aCL-APA and/or positive LA in patients with normal-tension glaucoma and POAG than in controls. However, the difference was not statistically significant [80]. Furthermore, comparison of Tsakiris' patients and the patients of this study is not meaningful because of the different mean age of the two cohorts (the patients of Tsakiris' study were 15 years older).…”

Section: Discussionmentioning

confidence: 64%