Lupus anticoagulant in patients with peripheral vascular disease: A prospective study

Abstract

The high prevalence of LAC in patients with peripheral vascular disease and the associated increased risk of early graft thrombosis may justify routine testing by DRVVT prior to reconstructive vascular surgery. Treatment of these patients with antiplatelet agents or formal anticoagulation perioperatively should be considered.

Circulating Markers of Abdominal Aortic Aneurysm Presence and Progression

“…Proteins involved in, stimulated by or associated with thrombosis have been the biomarkers most commonly assessed in AAA. Markers evaluated include fibrinogen, D-dimer, homocysteine, tissue plasminogen activator, von Willebrand factor, soluble thrombomodulin, plasminogen activator inhibitor-1, activated protein C-protein C inhibitor complexes, plasmin-antiplasmin complexes, P-selectin, thrombin-antithrombin III complex and fibrinogen degradation products [49-58,61-73,75]. The association between plasma fibrinogen and AAA has been studied extensively, with 5 of 10 investigations reporting higher concentrations in patients with AAA (Table I) [49-58].…”

“…Markers evaluated include fibrinogen, D-dimer, homocysteine, tissue plasminogen activator, von Willebrand factor, soluble thrombomodulin, plasminogen activator inhibitor-1, activated protein C-protein C inhibitor complexes, plasmin-antiplasmin complexes, P-selectin, thrombin-antithrombin III complex and fibrinogen degradation products [49-58,61-73,75]. The association between plasma fibrinogen and AAA has been studied extensively, with 5 of 10 investigations reporting higher concentrations in patients with AAA (Table I) [49-58]. The studies showing no association generally included very small numbers of patients [51,54,57,58] except for one investigation carried out exclusively in smokers [56].…”

“…The association between plasma fibrinogen and AAA has been studied extensively, with 5 of 10 investigations reporting higher concentrations in patients with AAA (Table I) [49-58]. The studies showing no association generally included very small numbers of patients [51,54,57,58] except for one investigation carried out exclusively in smokers [56]. Unlike other studies listed in Table I, controls in the study by Franks et al did not have an AAA excluded by imaging.…”

Antiphospholipid Antibodies and Atherosclerosis: Insights from Systemic Lupus Erythematosus and Primary Antiphospholipid Syndrome

“…The platelet neutralization procedure in the DRVVT was found in 26 out of the 60 (43%) vascular patients compared with none of the 20 general surgical controls [30], though a later survey found a lower 4% prevalence of LA in 150 patients with peripheral vascular disease [31].…”

Epidemiology of Antiphospholipid Syndrome

“…No association of anti-␤ 2 GPI and coronary atherosclerosis was found in a cross-sectional study of 97 subjects [33]. A study of 60 peripheral vascular disease patients found the LA in 43% versus 0% of controls [34].…”