Lupus Anticoagulant Associated with Specific Inhibition of Factor VII in a Patient with AIDS

Ndimbie, Oliver K.; Raman, B. K. S.; Saeed, Sheikh M.

doi:10.1093/ajcp/91.4.491

Cited by 17 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…penicillins (Mehta et al , 1992) and the cephalosporins (Kaiser et al , 1991) have been reported. Acquired factor VII inhibitors have also been reported occurring either spontaneously (Meade, 1988; Ndimbie et al , 1989; de Raucourt et al , 1994; Kamikubo et al , 2000) or in association with other diseases, e.g. myeloma (Elezovic et al , 1989).…”

Section: Acquired Factor VII Deficiencymentioning

confidence: 99%

Factor Vii Deficiency

Perry

2002

Br J Haematol

188

View full text Add to dashboard Cite

The rare inherited disorders of coagulation are a fascinating group of diseases that have provided us with important insights into the structure and function of their respective deficient protein(s). Factor VII (FVII) deficiency is the commonest of the Ôrare inherited disorders of coagulationÕ and this review summarizes current knowledge on the prevalence, diagnosis, management and the molecular pathology of factor VII deficiency.

show abstract

Section: Acquired Factor VII Deficiencymentioning

confidence: 99%

Factor Vii Deficiency

Perry

2002

Br J Haematol

188

View full text Add to dashboard Cite

show abstract

“…The reasonably frequent finding of a lupus inhibitor in our patients further heightened the possibility that FVII deficiency may have been due to development of an associated auto-antibody to FVII. 5 The observation that new lupus inhibitors may develop after SCT has been previously reported from this institution. 24 However, having failed to demonstrate a neutralizing antibody to FVII by mixing experiments, we used ELISA to search for auto-antibodies to FVII(a).…”

Section: Discussionmentioning

confidence: 57%

“…Associated disease states have included malignancy, 2 aplastic anemia, 3,4 and antiphospholipid antibodies. 5,6 In stem cell transplant (SCT) patients, a modest reduction in FVII levels (in the 25 to 50% range) has been described in the first 2 weeks following SCT. [7][8][9] In these cases it has often been associated with deficiencies of other factors such as FXII or protein C. 10 It has been suggested that the fall in FVII and protein C levels in this setting may be a harbinger of veno-occlusive disease of the liver (VOD).…”

mentioning

confidence: 99%

Acquired factor VII deficiency in hematopoietic stem cell transplant recipients

Toor

Slungaard

Hedner

et al. 2002

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:Acquired factor VII (FVII) deficiency in the absence of vitamin K deficiency, oral anticoagulant therapy, synthetic liver dysfunction, or DIC is rare, with only a handful of cases thus far reported. In the period from 1990 to 1996 we identified eight patients with acquired FVII deficiency, all of whom presented with prolongation of the prothrombin time (PT) in the first 2 weeks following stem cell transplantation (SCT). The mean plasma FVII clotting activity (FVII:c) was 22% (range 8-35%) with an approximately equivalent reduction in FVII antigen (FVII:Ag) level. Mean plasma levels of fibrinogen and factors II, V, IX, and X were normal. Protein C activity was significantly depressed in only one of the three patients in whom it was measured. Several patients experienced bleeding complications, and hemorrhage directly accounted for death in two cases. Veno-occlusive disease of the liver developed in three patients. We conclude that FVII deficiency should be considered in the differential diagnosis of prolonged PT in patients who have recently undergone SCT. The mechanism of this acquired deficiency state remains to be defined.

show abstract

“…Prothrombin antibodies are classically associated with lupus inhibitors [3][4][5][6] but antibodies to other clotting factors such as factors VII, VIII and X are described [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Life-threatening bleeding in a patient with a lupus inhibitor and probable acquired factor VII deficiency

Lim¹,

Zuha²,

Burt³

et al. 2006

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

We report the case of a 71-year-old man on warfarin for chronic atrial fibrillation presenting with a massive spontaneous soft tissue bleed. Despite reversing the effects of warfarin with large doses of intravenous vitamin K and fresh frozen plasma, bleeding continued, and his prothrombin time and activated partial thromboplastin time remained prolonged. The prothrombin time and activated partial thromboplastin time failed to correct with 50% normal plasma. Further investigations confirmed a lupus inhibitor with low levels of factors II, V, VII and XI. Factor II, V and XI levels normalized, however, when the patient's plasma was diluted 1:16 in buffer, suggesting the lupus inhibitor may have been interfering with these factor assays causing artefactual low results. Factor VII levels remained consistently low at all dilutions. The patient subsequently died following a massive left haemothorax despite surgical intervention and treatment with activated recombinant factor VII concentrate. We presumed the primary problem was bleeding from a local vascular lesion but the patient was never well enough to undergo confirmatory angiography. This case highlights the fact that patients with lupus inhibitors can develop severe haemorrhagic complications, and illustrates the complexities involved in both the investigation and treatment of abnormal bleeding in these patients.

show abstract

Lupus Anticoagulant Associated with Specific Inhibition of Factor VII in a Patient with AIDS

Cited by 17 publications

References 11 publications

Factor Vii Deficiency

Factor Vii Deficiency

Acquired factor VII deficiency in hematopoietic stem cell transplant recipients

Life-threatening bleeding in a patient with a lupus inhibitor and probable acquired factor VII deficiency

Contact Info

Product

Resources

About