Lupus Anticoagulant: A Familial Observation

Rouget, J; Goudemand, Jenny; Montreuil, G; Cosson, Alain; Jaillard, J

doi:10.1016/s0140-6736(82)91726-3

Cited by 31 publications

(8 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The paternal haplotype A30; Cw3; B60; DR4; DRw53; DQw3 has been shown to be associated with aCL in an English Canadian family; both in asymptomatic individuals and those with APS secondary to SLE and autoimmune thyroid disease [ 57 ]. The occurrence of LA in families with haplotypes containing either DR4 or DR7 has also been demonstrated [ 58 , 59 ]. In a family study in which all members had SLE and presented with various APS manifestations, a mother and her twins shared a haplotype that included DR4, DRw53 and DQw7 [ 60 ].…”

Section: Genes and The Environment In Apsmentioning

confidence: 99%

Pathophysiology of the antiphospholipid antibody syndrome

Willis

Pierangeli

2011

Autoimmun Highlights

View full text Add to dashboard Cite

Antiphospholipid antibodies (aPL) are associated with the recurrent pregnancy loss and thrombosis that characterizes the antiphospholipid antibody syndrome (APS). Although the ontogeny of these pathogenic antibodies has not been fully elucidated, there is evidence that indicates the involvement of both genetic and environmental factors. The ability of aPL to induce a procoagulant phenotype in APS patients plays a central role in the development of arterial and venous thrombotic manifestations typical of the disease. Inflammation serves as a necessary link between this procoagulant phenotype and actual thrombus development and is an important mediator of the placental injury seen in APS patients with obstetric complications. Recent evidence has indicated a role for abnormal cellular proliferation and differentiation in the pathophysiology of APS, especially in those patients with pregnancy morbidity and other more atypical manifestations that have no identifiable thrombotic cause. The interplay of genetic and environmental factors responsible for aPL development and the mechanisms by which these antibodies produce disease in APS patients is the focus of this review.

show abstract

Section: Genes and The Environment In Apsmentioning

confidence: 99%

Pathophysiology of the antiphospholipid antibody syndrome

Willis

Pierangeli

2011

Autoimmun Highlights

View full text Add to dashboard Cite

show abstract

“…The most consistent HLA associations in families with APS are HLA-DR4 and DRw53; other less consistent associations include DR7, DQw3, DQw7, A30, Cw3 and B60 [67][68][69][70]. In non-familial population studies HLA-DR4 and DRw53 were also consistently associated with APS disease characteristics in addition to DR7 and DQB1*0302 [71][72][73].…”

Section: Genetics Of Apsmentioning

confidence: 99%

Antiphospholipid Syndrome - An Evolving Story of a Multisystemic Disease

Pierangeli¹,

Harper²,

Harris³

2012

Antiphospholipid Syndrome

View full text Add to dashboard Cite

“…Following the initial report by Harvey in 1966, two pairs of siblings with positive LA test were described [ 2 ] , followed by reports of sisters with SLE, C4 deletion, and biologic false-positive tests for syphilis [ 3 ] , and a mother and daughter with positive LA tests [ 4 ] .…”

Section: Multiplex Antiphospholipid Syndrome Familiesmentioning

confidence: 99%