Lupresan, a new drug that prevents or reverts the formation of nonbilayer phospholipid arrangements that trigger a murine lupus resembling human lupus

Reséndiz-Mora, Albany; Landa, Carla; Sánchez-Barbosa, Sandra; Meza‐Toledo, Sergio Enrique; Santiago-Hernández, Juan Carlos; Wong, Carlos; Baeza, Isabel; Wong-Baeza, Carlos

doi:10.1016/j.bbrc.2018.12.119

Cited by 3 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The membranes of smooth liposomes have less complexity than the membranes of liposomes bearing NPA. This difference in membrane complexity is revealed because the laser beam dispersion is higher in liposomes bearing NPA than in smooth liposomes [20,34].…”

Section: Analysis Of Npa Formation On Liposomesmentioning

confidence: 99%

“…Another possible mechanism that would explain the involvement of these drugs in the development of lupus is the stabilization of NPA on cell membranes, which then become immunogenic. We have explored this mechanism in a mouse model of lupus induced by drug-stabilized NPA on liposomes [20].…”

Section: Drug-induced Lupus In Humansmentioning

confidence: 99%

“…This mouse model of lupus can be developed by the administration of liposomes bearing drug-stabilized NPA, or by the administration of the NPA-stabilizing drugs alone; these drugs include chlorpromazine (anti-psychotic), hydralazine (antihypertensive -diuretic) and procainamide (anti-arrhythmic) [20]. Mice develop IgG anti-NPA antibodies, followed by anti-cardiolipin, anti-histone, anti-nuclear and anti-coagulant antibodies.…”

Section: Mouse Model Of Lupus Induced By Lipids Associated In Npamentioning

confidence: 99%

See 2 more Smart Citations

Anti-Non-Bilayer Phospholipid Arrangement Antibodies Trigger an Autoimmune Disease Similar to Systemic Lupus Erythematosus in Mice

Reséndiz-Mora¹,

Tescucano²,

Barrera-Aveleida³

et al. 2023

Systemic Lupus Erythematosus - Pathogenesis and Management

Self Cite

View full text Add to dashboard Cite

Anti-lipid antibodies are present in some infectious and autoimmune diseases, such as Systemic Lupus Erythematosus (SLE). Particularly, anti-non-bilayer phospholipid arrangement (NPA) antibodies have been detected in patients with SLE, and these antibodies trigger a disease similar to human lupus in mice. NPA are lipid associations different from the lipid bilayer of cellular membranes and, since they are transient, they are not immunogenic. However, if NPA are stabilized by drugs, they induce an immune response with the production of anti-NPA antibodies, which bind to NPA on cell membranes and generate cell lysis. As a result, intracellular antigens are exposed and trigger an immune response that generates more auto-antibodies. In this chapter, we describe the formation and stabilization of NPA, the induction of B cell responses to generate anti-NPA antibodies, and the characteristics that the disease caused by these antibodies in mice shares with human lupus.

show abstract

Section: Analysis Of Npa Formation On Liposomesmentioning

confidence: 99%

Section: Drug-induced Lupus In Humansmentioning

confidence: 99%

Section: Mouse Model Of Lupus Induced By Lipids Associated In Npamentioning

confidence: 99%

See 1 more Smart Citation

Anti-Non-Bilayer Phospholipid Arrangement Antibodies Trigger an Autoimmune Disease Similar to Systemic Lupus Erythematosus in Mice

Reséndiz-Mora¹,

Tescucano²,

Barrera-Aveleida³

et al. 2023

Systemic Lupus Erythematosus - Pathogenesis and Management

Self Cite

View full text Add to dashboard Cite

show abstract

“…To describe the transmembrane protein family of CPPs, the inverted micelle model has also been proposed. 47,48 Transmembrane protein CPPs are polypeptides rich in lysine and arginine that can penetrate the cell membrane at low temperatures, indicating that no energy is required for the process. According to the hypothesis, cationic residues (arginine and lysine) firstly combine with anionic phospholipids on the cell membrane 49 to form pocket micelles that encapsulate CPPs.…”

Section: Direct Penetrationmentioning

confidence: 99%

“…To describe the transmembrane protein family of CPPs, the inverted micelle model has also been proposed 47,48 . Transmembrane protein CPPs are polypeptides rich in lysine and arginine that can penetrate the cell membrane at low temperatures, indicating that no energy is required for the process.…”

Section: The Uptake Mechanism Of Cppsmentioning

confidence: 99%

The role of cell‐penetrating peptides in potential anti‐cancer therapy

Zhou

Zou

Cheng

et al. 2022

Clinical & Translational Med

View full text Add to dashboard Cite

Due to the complex physiological structure, microenvironment and multiple physiological barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site. Cell‐penetrating peptides (CPPs) are typically made up of 5–30 amino acids, and can be utilised as molecular transporters to facilitate the passage of therapeutic drugs across physiological barriers. Up to now, CPPs have widely been used in many anti‐cancer treatment strategies, serving as an excellent potential choice for oncology treatment. However, their drawbacks, such as the lack of cell specificity, short duration of action, poor stability in vivo, compatibility problems (i.e. immunogenicity), poor therapeutic efficacy and formation of unwanted metabolites, have limited their further application in cancer treatment. The cellular uptake mechanisms of CPPs involve mainly endocytosis and direct penetration, but still remain highly controversial in academia. The CPPs‐based drug delivery strategy could be improved by clever design or chemical modifications to develop the next‐generation CPPs with enhanced cell penetration capability, stability and selectivity. In addition, some recent advances in targeted cell penetration that involve CPPs provide some new ideas to optimise CPPs.

show abstract

Uptake pathways of cell-penetrating peptides in the context of drug delivery, gene therapy, and vaccine development

Dowaidar

2024

Cellular Signalling

View full text Add to dashboard Cite

Lupresan, a new drug that prevents or reverts the formation of nonbilayer phospholipid arrangements that trigger a murine lupus resembling human lupus

Cited by 3 publications

References 19 publications

Anti-Non-Bilayer Phospholipid Arrangement Antibodies Trigger an Autoimmune Disease Similar to Systemic Lupus Erythematosus in Mice

Anti-Non-Bilayer Phospholipid Arrangement Antibodies Trigger an Autoimmune Disease Similar to Systemic Lupus Erythematosus in Mice

The role of cell‐penetrating peptides in potential anti‐cancer therapy

Uptake pathways of cell-penetrating peptides in the context of drug delivery, gene therapy, and vaccine development

Contact Info

Product

Resources

About