Lupene triterpenoids from Glochidion eriocarpum

Wang, Hui; Li, Man-Moon

doi:10.1016/s0031-9422(00)88976-1

Cited by 27 publications

(24 citation statements)

References 4 publications

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“…The following compounds were isolated from the n-hexane soluble fraction from chloroform extract of the aerial part compounds: 3�-O-octadecanoillupeol (1) (Ammann, Richarz, Wirthlin, & Wendisch, 1982;Brum, Honda, Hess, Cavalheiro, & Monache, 1998;Hui, & Li, 1976;Kwon et al, 2003;Matsunaga, Tanaka, & Okagi, 1988;Miranda, Silva, Duarte, & Filho, 2007;Mustafa et al, 2000;Wenkert, Baddeley, Burfitt, & Moreno, 1978;Yang, Gao, & Jia, 2003), glut-5-en-3�-ol (2) (Carvalho & Seita, 1993;Khan, Ahmed, Kazmal, & Malik, 1987;Matsunaga et al, 1988) and 24-methylenocicloartan-3�-ol (3) (Audier, Beugelmans, & Das, 1966;Passannanti, Paternostro, Piozzi, & Faarax, 1985;Rustaiyan, Niknejad, Sharif, & Izaddoost, 1982;Teresa et al, 1987) (Figure 1). Ellagic acid (4) (Bindra, Satti, & Suri, 1988;Hillis & Yazaki, 1973;Hussain, 1974;Pakulski & Budzianowski, 1996) and �-sitosterol (5) (Dellagreca, Monaco, & Previtera, 1990;Seo, Tomita, & Tori, 1978) were isolated from the acetone extract of the aerial part compounds (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Chemical constituents of Euphorbia hyberna L. (Euphorbiaceae)

Ferreira

Carvalho

Sequeira

et al. 2012

Natural Product Research

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Chemical investigation of the aerial part and the roots of Euphorbia hyberna L. subs. hyberna. resulted in the isolation and identification of four triterpenoids (3β-O-octadecanoyllupeol (1), glut-5-en-3β-ol (2), 24-methylenecicloartan-3β-ol (3) and cicloart-23-ene-3β,25-diol (6)) along with the phenolic compounds ellagic acid (4) and 3,3'-di-O-methylellagic acid (7). Although these are all known compounds, this is the first report of their isolation from this plant. Their structures were elucidated on the basis of spectral methods, including 2D NMR experiences, and confirmed by comparing with the literature data.

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Section: Resultsmentioning

confidence: 99%

Chemical constituents of Euphorbia hyberna L. (Euphorbiaceae)

Ferreira

Carvalho

Sequeira

et al. 2012

Natural Product Research

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“…Previous phytochemical investigations revealed the isolation of glochidiol, glochilocudiol, glochidone and dimedone (Talapatra et al, 1973). Many secondary metabolites were isolated from Glochidion species, including tannins (Chen et al, 1995), glycosides (Otsuka et al, 2003), lignans (Otsuka et al, 2000), terpenoids (Hui and Li, 1976).…”

Section: Introductionmentioning

confidence: 99%

Antitumor, Analgesic and Anti-inflammatory Activities of Glochidion multiloculare (Rottler ex Willd) Voigt

et al. 2015

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The antitumor, analgesic and anti-inflammatory activities of the methanol extract (MEGM) of Glochidion multiloculare and its petroleum ether (PEFGM), carbon tetrachloride (CTFGM) and chloroform (CHFGM) soluble fractions were investigated. The antitumor activity of the extract/fractions was determined against Ehrlich's ascites carcinoma (EAC) in mice at 20 mg/kg body weight intraperitoneally. Increase of survival time by 24 ± 0.12, 26 ± 0.40, 21 ± 0.12 and 27 ± 0.42 days was observed by the MEGM, PEFGM, CTFGM and CHFGM treated tumor bearing mice compared to the control group (20 ± 0.12 days). Hematological studies revealed that heamoglobin (Hb) content was decreased in EAC treated mice whereas restoration to normal levels was observed in extract/fractions treated animals. Significant decrease in RBC and increase in WBC counts were observed in extract/fractions treated animals when compared to EAC affected animals. Both extract and fractions at the dose of 100 mg/kg b.w. significantly increased the pain threshold in tail immersion method and reduced the writhing caused by acetic acid induced method. The MEGM, PEFGM, CTFGM and CHFGM showed anti-inflammatory activities at 100 mg/kg b.w. This is the first report of antitumor, analgesic and anti-inflammatory potential of G. multiloculare.

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“…Many secondary metabolites were isolated from Glochidion species, including tannins (Chen et al, 1995), glycosides (Otsuka et al, 2003), lignans (Otsuka et al, 2000), terpenoids (Hui and Li, 1976). Previous investigation of Glochidion multiloculare revealed glochidiol, glochilocudiol, glochidone and dimedone (Talapatra et al, 1973).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Cytotoxic Activities of the Extracts of Glochidion multiloculare

et al. 2013

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The current study was designed to investigate the antimicrobial and cytotoxic activities of methanol extract (MEGM), petroleum ether fraction (PEFGM), carbontetrachloride fraction (CTFGM), chloroform fraction (CFFGM) and aquous fraction (AQFGM) of stem bark of Glochidion multiloculare (Euphorbiaceae). Antimicrobial activity was evaluated by disc diffusion method and cytotoxic activity by brine shrimp lethality bioassay. In case of antimicrobial screening the CFFGM showed moderate inhibitory activity against B. subtilis having the zone size 12 mm and against Escherichia coli and Escherichia coli were 11 mm, while in the brine shrimp lethality bioassay, the petroleum ether soluble fraction revealed the highest cytotoxicity having LC 50 of 3.11 g/ml.

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Lupene triterpenoids from Glochidion eriocarpum

Cited by 27 publications

References 4 publications

Chemical constituents of Euphorbia hyberna L. (Euphorbiaceae)

Chemical constituents of Euphorbia hyberna L. (Euphorbiaceae)

Antitumor, Analgesic and Anti-inflammatory Activities of Glochidion multiloculare (Rottler ex Willd) Voigt

Antimicrobial and Cytotoxic Activities of the Extracts of Glochidion multiloculare

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