Lungenveränderungen durch Sillimanitstaub

Jötten, K. W.; Eickhoff, W.

doi:10.1007/bf02124656

Cited by 5 publications

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“…There is no evidence that the fibrosis is due to pulmonary infection or that infection is a necessary part of the fibrogenic process, as it was in the experiments of Jotten and Eickhoff (1943). Sterile apparatus was used throughout the experiments, and at the end of a series of injections the remaining dust suspension was expelled through the cannula which had been introduced into the rats' tracheas, plated on culture media, and shown to be sterile.…”

Section: Discussionmentioning

confidence: 99%

Aluminium Pneumoconiosis II. Effect on the Rat Lung of Intratracheal Injections of Stamped Aluminium Powders Containing Different Lubricating Agents and of a Granular Aluminium Powder

Corrin

1963

Occupational and Environmental Medicine

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Section: Discussionmentioning

confidence: 99%

Aluminium Pneumoconiosis II. Effect on the Rat Lung of Intratracheal Injections of Stamped Aluminium Powders Containing Different Lubricating Agents and of a Granular Aluminium Powder

Corrin

1963

Occupational and Environmental Medicine

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“…4 An artificial silicate of aluminium has been reclaimed from a dump in rural Western Australia since 1975. The dump of about 100 000 tons was created during World War II when alunite clay from a salt lake was collected for the extraction of potash.…”

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confidence: 99%

Pulmonary disease from occupational exposure to an artificial aluminium silicate used for cat litter.

Musk¹,

Greville²,

Tribe³

1980

Occupational and Environmental Medicine

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All available workers engaged in bagging an artificial crystalline aluminium silicatethe kiln-dried residue from the calcining and water extraction of alunite (a hydrated sulphate of aluminium and potassium) that is currently classified as a nuisancedust-were studiedaftera complaint of respiratory and systemic symptoms, including arthritis, by an employee of the factory, who showed physiological and radiographic evidence of diffuse pulmonary fibrosis and in whom lung biopsy showed diffuse fibrosis with granulomas. Inhalation challenge produced a transient decrease in transfer factor and transfer factor standardised for alveolar volume. Twenty-five subjects were known to have been exposed at some time to the dust of alunite-residue. Of the 17 who could be contacted, all agreed to attend for respiratory questionnaire and occupational history, pulmonary function testing (spirometry, lung volumes, gas transfer), and posteroanterior chest radiograph. Six subjects considered that occupational exposure to the dust was responsible for respiratory symptoms. Three subjects had abnormality of the chest radiograph consistent with pulmonary fibrosis. The mean percentage of predicted transfer factor standardised for effective alveolar volume was 71f1 % in subjects with abnormal chest radiographs and 86 6 '/ in subjects with normal radiographs (p = 0 10). There was a trend in the correlation between the percentage of predicted transfer factor standardised for effective alveolar volume and total dust exposure (sum of the products of grade of severity of each exposure period and duration of each exposure period in months) (r = 0 40 p = 0 10). This study suggests that there may be a relation between inhalation of the dust of this form of aluminium silicate and pulmonary fibrosis.Although pulmonary fibrosis has been described from occupational exposure to dusts of aluminium powder1 and aluminium oxide,2 and asthma has been associated with the smelting of aluminium,3 there is no record of pulmonary disease in man resulting from exposure to other compounds containing aluminium, although sillimanite, an aluminium silicate, may cause diffuse and nodular pulmonary fibrosis in rabbits.4 An artificial silicate of aluminium has been reclaimed from a dump in rural Western Australia since 1975. The dump of about 100 000 tons was created during World War II when alunite clay from a salt lake was collected for the extraction Received 10 May 1979 Accepted 17 October 1979 of potash. Alunite, a hydrated sulphate of aluminium and potassium, was calcined and then leached to yield potash (K2SO4). The residue was dumped in a pile on the shores of the lake. This material, when dried to a water content of 2-3 %, has been found to be highly absorbent, and since 1975 it has been reclaimed, dried, and packaged for retail as cat litter. Analysis of this alunite-residue has shown it to consist predominantly of crystalline aluminium silicate (mullite) with no fibrous content (table 1). It has been classified as a "nuisance dust" in industry with...

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Silikatosen

Behrens¹

1956

Erkrankungen Der Atmungsorgane

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Lungenveränderungen durch Sillimanitstaub

Cited by 5 publications

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Aluminium Pneumoconiosis II. Effect on the Rat Lung of Intratracheal Injections of Stamped Aluminium Powders Containing Different Lubricating Agents and of a Granular Aluminium Powder

Aluminium Pneumoconiosis II. Effect on the Rat Lung of Intratracheal Injections of Stamped Aluminium Powders Containing Different Lubricating Agents and of a Granular Aluminium Powder

Pulmonary disease from occupational exposure to an artificial aluminium silicate used for cat litter.

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