Lungenfunktionsstudien nach Homo- und Autotransplantation bzw. Denervation der linken Lunge und anschließender Unterbindung der rechten Pulmonalarterie<sup>1</sup>

Bücherl, E. S.; Lesch, P.; Nasseri, M.; Prondzynski, B. v.

doi:10.1055/s-0028-1101159

Cited by 2 publications

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“…The question of whether both these parameters would reflect ischemic lung injury in a model not restricting ventilation and perfusion to the left lung only can not be answered on the basis of this study. Data in the literature are very confusing with respect to results on pulmonary vascular resistance and compliance of the lung with an without prescrvation (2,4,5,10,27,28), and data during the first 24 hours after transplantation are not available.…”

Section: Discussionmentioning

confidence: 99%

Improved Lung Preservation using Euro-Collins Solution for Flush-perfusion

Haverich

Aziz

Scott

et al. 1986

Thorac cardiovasc Surg

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Satisfactory extended preservation of the lung has been difficult to obtain. This study investigated the influence of different total volumes and flow rates during flush-perfusion of the lung, and their effect on pulmonary artery pressure, flow distribution, regional lung temperature and functional performance of the lungs following transplantation after 24 hours. Fifteen mongrel dogs served as donors of the heart and lung block. Cold modified Euro-Collins solution was used as flush perfusate. Pulmonary artery and perfusion-line pressures were measured. The regional lung temperature was measured at one minute intervals with 5 myocardial temperature probes. Flow distribution was determined with micro-aggregated albumin labelled with Technetium 99. The heart-lung block was harvested, the right lung removed, and samples taken for gamma-counting. The left lung was stored in cold Euro-Collins solution and then transplanted. The inspired oxygen fraction (FiO2) was set at 0.4 and was kept constant throughout the procedure and the entire postoperative course. There were 3 groups of 5 animals each. In group A, the flush perfusate was administered at a total volume of 20 cc/kg over a period of 6 minutes. In group B the same volume of perfusate was administered at a pulmonary artery pressure (PAP) of 18 to 20 mmHg, resulting in a considerably shorter perfusion time (1.3 minutes). In group C 60 cc/kg of perfusate were given at the same flow rate as in group B, also resulting in PAP of 18 to 20 mmHg, but the perfusion time was increased to 4 minutes. Thus, groups B and C investigated the effect of increased pressure and volume of perfusate, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Improved Lung Preservation using Euro-Collins Solution for Flush-perfusion

Haverich

Aziz

Scott

et al. 1986

Thorac cardiovasc Surg

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Sp�tergebnisse nach Homotransplantation einer Lunge

Bücherl

Masshoff

Nasseri

et al. 1964

Arch. f. klin. Chir

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Eine Unterteilung dieser Tiere in drei Gruppen (Tabelle 1) macht ersichtlich, dal3 bei der Gruppe I yon 17 Tieren vier fiberlebten, yon der Gruppe II bei gleicher Tierzahl ffinf, und yon der Gruppe III yon sechs zwei. Die mittlere ~berlebenszeit der spontan ad exitum gekommenen betrug fiir die einzelnen Gruppen 31,7, 13,8 und 16,2 Tage. Die transplantierte Lunge dieser Tiere war im Mittel 15,0, 29,0 bzw. 11,3 Tage belfiftet.In der Tabelle 2 sind yon den langffistig Uberlebenden die Beli~]. tungszeiten ffir das transplantierte Organ zusammengestellt. Nur yon der Gruppe I ging bei einem Tier Uberlebenszeit und Funktionszeit

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Lungenfunktionsstudien nach Homo- und Autotransplantation bzw. Denervation der linken Lunge und anschließender Unterbindung der rechten Pulmonalarterie¹

Cited by 2 publications

References 0 publications

Improved Lung Preservation using Euro-Collins Solution for Flush-perfusion

Improved Lung Preservation using Euro-Collins Solution for Flush-perfusion

Sp�tergebnisse nach Homotransplantation einer Lunge

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Lungenfunktionsstudien nach Homo- und Autotransplantation bzw. Denervation der linken Lunge und anschließender Unterbindung der rechten Pulmonalarterie1

Cited by 2 publications

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Improved Lung Preservation using Euro-Collins Solution for Flush-perfusion

Improved Lung Preservation using Euro-Collins Solution for Flush-perfusion

Sp�tergebnisse nach Homotransplantation einer Lunge

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Lungenfunktionsstudien nach Homo- und Autotransplantation bzw. Denervation der linken Lunge und anschließender Unterbindung der rechten Pulmonalarterie¹