Lungenfunktion in Kindheit und Adoleszentenalter: Einfluss von Frühgeburtlichkeit und bronchopulmonaler Dysplasie

Segerer, Florian; Speer, Christian P.

doi:10.1055/s-0042-101798

Cited by 2 publications

(2 citation statements)

References 78 publications

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“…Segerer et al 19 in a more recent study reaffirms the significant difference in respiratory function for VLBW and especially ELBW neonates not diagnosed with BPD and term controls. Further improvements in survival after the year 2000 20 increased the numbers of VLBW neonates who survive without BPD and have expanded the pool of very premature neonates who need long-term respiratory monitoring.…”

Section: Discussionmentioning

confidence: 74%

Very preterm neonates receiving “aggressive” nutrition and early nCPAP had similar long-term respiratory outcomes as term neonates

et al. 2019

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BackroundThe impact of the consistent implementation of “aggressive” nutrition by means of intensive early neonatal nutritional support up to 40–44 weeks postmenstrual age and the use of nasal continuous positive airway pressure (nCPAP) within the first hour of life on the respiratory function of very premature neonates (VPN) at school age is unclear.MethodRespiratory function was evaluated in 108 VPN and 70 term controls. Growth, frequency of lower respiratory tract infections, re-hospitalization, and spirometry were recorded up to 8–10 years of age. Comparison was carried out between the two study groups.ResultsThere was no significant difference in forced expiratory volume in 1 s and forced vital capacity at 8 years of age, and also in lower respiratory tract infections and re-hospitalization due to them, up to 8 years of age between preterm and term neonates. No significant difference was found in spirometry measurements neither between premature neonates with and without BPD nor between the two subgroups of preterms and term neonates.Conclusion“Aggressive” nutrition, persistent nCPAP use, and their impact on early postnatal growth probably positively affect the respiratory function of our study population. These very encouraging results need to be confirmed by larger studies.

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Section: Discussionmentioning

confidence: 74%

Very preterm neonates receiving “aggressive” nutrition and early nCPAP had similar long-term respiratory outcomes as term neonates

et al. 2019

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“…Surviving children with BPD develop proliferation of airway smooth muscle cells and epithelial cells, airway remodeling, and combined inflammatory infiltration of the lungs, resulting in airway hyperresponsiveness, impaired lung function, and increased chances of respiratory viral infections in the first year of life ( 38 , 57 ). Based on the follow-up of children with BPD, this impairment of lung function lasts until adolescence or even an adult stage and may be accompanied by long-range respiratory disorders such as chronic obstructive pulmonary disease (COPD) or asthma ( 58 , 59 ). Saarenpää et al , in their age-matched study on 29 adults (age group, 18-27 years) with a previous diagnosis of BPD with age-matched healthy adults, documented that first-second exertional expiratory volume and first-second exertional expiratory volume/exertional lung capacity were significantly lower than those in healthy adults ( 60 ).…”

Section: Pathogenesis and Current Situation Of Bpdmentioning

confidence: 99%

Insulin‑like growth factor‑1: A potential target for bronchopulmonary dysplasia treatment (Review)

Zhang

Xue

et al. 2022

Exp Ther Med

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Bronchopulmonary dysplasia (BPD) is a common respiratory disorder among preterm infants, particularly low-birth-weight infants (LBWIs) and very-low-birth-weight infants (VLBWIs). Although BPD was first reported 50 years ago, no specific drugs or efficient measures are yet available for prevention or treatment. Insulin-like growth factor-1 (IGF-1) belongs to the insulin family. It promotes mitosis and stimulates cell proliferation and DNA synthesis, the primary factors involved in pulmonary development during the fetal and postnatal periods. Several studies have reported that IGF-1 exerts certain effects on BPD genesis and progression by regulating BPD-related biological processes. In addition, exogenous addition of IGF-1 can alleviate lung inflammation, cell apoptosis and eliminate alveolar development disorders in children with BPD. These findings suggest that IGF-1 could be a new target for treating BPD. Here, we summarize and analyze the definition, pathogenesis, and research status of BPD, as well as the pathogenesis of IGF-1 in BPD and the latest findings in related biological processes. Contents 1. Introduction 2. Definition and naming of BPD 3. Pathogenesis and current situation of BPD 4. Biological characteristics and activity of IGF-1 5. IGF-1 in lung development 6. IGF-1 and lung injury 7. Possible underlying mechanisms of IGF-1 in BPD development 8. IGF-1 as a new option for BPD treatment 9. Challenges and prospects of IGF-1 10. Conclusion

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Lungenfunktion in Kindheit und Adoleszentenalter: Einfluss von Frühgeburtlichkeit und bronchopulmonaler Dysplasie

Cited by 2 publications

References 78 publications

Very preterm neonates receiving “aggressive” nutrition and early nCPAP had similar long-term respiratory outcomes as term neonates

Very preterm neonates receiving “aggressive” nutrition and early nCPAP had similar long-term respiratory outcomes as term neonates

Insulin‑like growth factor‑1: A potential target for bronchopulmonary dysplasia treatment (Review)

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