Lungenfunktion im Alter: Brauchen wir neue Referenzwerte?

Marek, W.; Marek, É. M.; Mückenhoff, K.; Smith, H. D.; Kotschy-Lang, N.; Kohlhäufl, Martin

doi:10.1055/s-0028-1119704

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Lung function measurements [22-24] of static and dynamic lung volumes and maximal expiratory flows and volumes, using MasterLab, or PneumoScreen systems (CareFusion, Höchberg) were performed according to the recommendations and the widely used reference formulas of the ECCS [2]. At first subjects exhaled under normal breathing conditions down to the residual volume (RV), followed by inspiratory vital capacity (IVC) and expiratory vital capacity manoeuvre (EVC).…”

Section: Methodsmentioning

confidence: 99%

Lung function in our aging population

Marek

Mückenhoff

et al. 2011

Eur J Med Res

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Aims of investigationThe chronological age of the Caucasian population and their anthropometrical data have significantly changed within the last five decades. Therefore the question arises whether or not the commonly used reference values of the European Community (ECCS) for lung function may still be accepted today. Since these values were obtained in the 1960s from subjects in a limited age range. For the elderly, the measured values are deduced by extrapolation beyond the range of reference equations which had been obtained in a different population. Therefore decisions concerning elderly and smaller subjects concerning remuneration due to impaired lung function after industrial exposure on the basis of EGKS values are questionable.MethodsLung function tests were performed by pneumotachography, recording static lung volumes and flow-volume-curves in 262 asymptomatic non smoking males, aged 20 to 90 years. Measurements were performed with the MasterLab, or Pneumo-Screen systems (CareFusion, Höchberg). Results were compared to the reference values of ECCS, SAPALDIA and LuftiBus.ResultsFor simplicity analysis of age and height dependence of investigated respiratory parameters (VC, FVC, FEV1, FEV1%FVC, PEF, MEF75,50,25) can be described by linear functions (y = a * height - b * age + c). The forced expiratory vital capacity, FVC, was calculated by FVC = 0.0615*H - 0.0308*A - 4.673; r = 0.78. Mean FVC for younger subjects was found to be 104.7 ± 10.7% of the ECCS reference values and 96.5 ± 11.8% in older subjects. For most parameters investigated linear regressions on age were steeper than described by the ECCS reference values. The regression of lung function to height largely follows the ECCS prescriptions.SummaryBochum lung function values of younger healthy subjects were higher compared to the reference values of the ECCS and showed a steeper age descent. The alternatively discussed reference values of the SAPALDIA-, or LuftiBus-Study are higher, but do not cover all necessary parameters and/or the age range. A multi centre study for contemporary reference values is recommended.

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Section: Methodsmentioning

confidence: 99%

Lung function in our aging population

Marek

Mückenhoff

et al. 2011

Eur J Med Res

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“…Lung function measurements [21] of static and dynamic lung volumes and maximal expiratory flows, using MasterLab, or PneumoScreen systems (Cardinal Health, Höchberg) were performed according to the recommendations and reference formulas of the ECCS [2]. According to the manufactures guidelines, calibrations were performed daily.…”

Section: Methodsmentioning

confidence: 99%

Time for new reference values for ventilatory lung function

Marek

Mückenhoff

et al. 2009

Eur J Med Res

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ObjectiveThe anthropometrical data of our aging population has significantly changed within the last five decades. Therefore the question arises whether or not the commonly used reference values of the European Community (ECCS) for lung function, may still be accepted today. Measured values for elderly are classified by extrapolation beyond the range of reference equations.Materials and methodsLung function was examined by pneumotachography for recording static lung volumes and flow-volume-curves in 257 asymptomatic non smoking males, aged 20-90 years. Results were compared to the reference values of ECCS, SAPALDIA, LuftiBus, and NHANES.ResultsFor analysis age and height dependence of investigated respiratory parameters (VC, FVC, FEV1, FEV1 %FVC, PEF, MEF75,50,25) can for simplicity be described by linear functions (y = a · height(H)-b · age (A)+c). The forced expiratory volume in one second, FEV1, was calculated by FEV1 = 0.0432 · H-0.0347 · A-2.114; where H - height, A - age; r = 0.78. Mean FEV1 for younger subjects was found to be 106.1 ± 11.2% of the ECCS reference values and 97.8 ± 11.7% in older subjects. For all parameters investigated linear regressions on age were steeper than described by the ECCS reference values. The regression of lung function to height largely follows the ECCS prescriptions.SummaryBochum lung function values of healthy subjects showed a steeper age descent compared to the reference values of the ECCS. The alternatively discussed reference values of the SAPALDIA-, NHANES- or LuftiBus-Study are higher, but do not cover all necessary parameters and/or the age range. A multi centre study for contemporary reference values is recommended.

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Regional differences in prediction models of lung function in Germany

et al. 2010

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Background Little is known about the influencing potential of specific characteristics on lung function in different populations. The aim of this analysis was to determine whether lung function determinants differ between subpopulations within Germany and whether prediction equations developed for one subpopulation are also adequate for another subpopulation. Methods Within three studies (KORA C, SHIP-I, ECRHS-I) in different areas of Germany 4059 adults performed lung function tests. The available data consisted of forced expiratory volume in one second, forced vital capacity and peak expiratory flow rate. For each study multivariate regression models were developed to predict lung function and Bland-Altman plots were established to evaluate the agreement between predicted and measured values. Results The final regression equations for FEV 1 and FVC showed adjusted r-square values between 0.65 and 0.75, and for PEF they were between 0.46 and 0.61. In all studies gender, age, height and pack-years were significant determinants, each with a similar effect size. Regarding other predictors there were some, although not statistically significant, differences between the studies. Bland-Altman plots indicated that the regression models for each individual study adequately predict medium (i.e. normal) but not extremely high or low lung function values in the whole study population. Conclusions Simple models with gender, age and height explain a substantial part of lung function variance whereas further determinants add less than 5% to the total explained r-squared, at least for FEV1 and FVC. Thus, for different adult subpopulations of Germany one simple model for each lung function measures is still sufficient.

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Lungenfunktion im Alter: Brauchen wir neue Referenzwerte?

Cited by 3 publications

References 18 publications

Lung function in our aging population

Lung function in our aging population

Time for new reference values for ventilatory lung function

Regional differences in prediction models of lung function in Germany

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