Lung water is a critical determinant of functional capacity in congestive heart failure

Sverzellati, Enrico; Espinas, Rosa D.; Giorgi‐Pierfranceschi, Matteo; Meny, Miguel G.; Crippa, Giuseppe; Reyes, Ariel J.

doi:10.1016/s1071-9164(98)90054-9

Cited by 1 publication

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“…Upon prolonged administration, the cardiac index may stay below, equal or surpass its pre-treatment value, but the magnitude of these changes is generally low. 7,8 There is a lack of correlation between variables indicating effort capacity and cardiac output in patients suffering from chronic CHF, but we have found that the NYHA functional class 9 correlates positively and that the 6-min mean walking velocity 10 correlates negatively with clinical ( Figure 1) and radiological 11 increasing ordinal indicators of the magnitude of lung congestion and pulmonary water and with the cardiothoracic ratio. 12 These findings strongly suggest that the beneficial effects of diuretics on the main symptoms of CHF are mainly due to the decrease in thoracic fluid that results from their diuretic action.…”

Section: Introductionmentioning

confidence: 66%

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Diuretics in the treatment of patients who present congestive heart failure and hypertension

Reyes¹

2002

J Hum Hypertens

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The main operational objective of diuretic therapy in patients who present congestive heart failure and hypertension is to reduce or to suppress excess bodily fluid. Effective diuretic therapy decreases cardiac size when the heart is dilated, and it reduces lung congestion and excess water. Consequently, external respiratory work diminishes and cardiac output would be redistributed in favour of systemic vascular beds other than that of the respiratory muscles; dyspnoea decreases markedly and there is a slight reduction in fatigue. This clinical improvement and the fall in body weight caused by diuretics entail an increase in effort capacity. Subsequent exercise training ameliorates the abnormal ventilatory response to physical effort and the skeletal muscle myopathy that occur in heart failure, and thereby it attenuates dyspnoea and decreases fatigue further. Loop and/or thiazide-type diuretics may be used to aug-

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Section: Introductionmentioning

confidence: 66%

“…The potassium-retaining diuretics amiloride and triamterene increase natriuresis by blocking a sodium channel involved in the exchange of this cation for potassium and hydrogen. 9 Spironolactone and potassium canrenoate compete with aldosterone for the intracellular receptor of this hormone in the tubular cells.…”

Section: Potassium-retaining Diureticsmentioning

confidence: 99%

Diuretics in the treatment of patients who present congestive heart failure and hypertension

Reyes¹

2002

J Hum Hypertens

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Lung water is a critical determinant of functional capacity in congestive heart failure

Cited by 1 publication

References 0 publications

Diuretics in the treatment of patients who present congestive heart failure and hypertension

Diuretics in the treatment of patients who present congestive heart failure and hypertension

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