Lung water and vascular permeability in sheep. Newborns compared with adults.

Hemodynamic evaluation of anesthetized baboons and piglets by transpulmonary thermodilution: Normal values and interspecies differences with respect to xenotransplantation

“…In Maryland minipigs (n = 38, 8‐16 kg), López‐Herce et al observed mean values of 198 mL/m 2 for GEDI and 16 mL/kg for ELWI, respectively . ELWI values determined by gravimetry in newborn healthy lambs were more than twice as high as in adult sheep (13.3 vs 6.1 mL/kg) …”

“…32 To ELWI values determined by gravimetry in newborn healthy lambs were more than twice as high as in adult sheep (13.3 vs 6.1 mL/ kg). 37 Lemson et al proposed that the lower GEDI values and higher ELWI values in younger children were a result of age-related changes in the ratio of lung weight to body weight and in the ratio of heart weight to BSA. 38 The greater lung weight in infants has consequences for calculating the (non-indexed) EVLW, for which the intrathoracic blood volume (ITBV) is needed.…”

Correlation of oxygenation with vascular permeability-surface area but not with lung water in humans with acute respiratory failure and pulmonary edema.

“…Patients 30 blood samples were collected at 1.5-2.0-s intervals by allowing blood to flow from a radial artery cannula into heparinized tubes mounted on a precisely timed rotating disc collector. Samples were analyzed exactly as described several times in the literature (9)(10)(11)(12)(13). Briefly, 125I and 51Cr activities were measured in a gamma spectrometer in each blood sample and a sample of the injected mixture.…”