Lung Ultrasound to Diagnose Pneumonia in Neonates with Fungal Infection

Ma, Hai-Ran; Fu, Wei

doi:10.3390/diagnostics12081776

Cited by 10 publications

(14 citation statements)

References 36 publications

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“…Forty-two consecutive infants with PH from May 2017 to December 2021 were included in this study. According to our clinical practice and literatures, the PH, pneumonia and meconium aspiration syndrome (MAS) can have some similar ultrasound manifestations, such as lung consolidation with air bronchograms (12)(13)(14)(15)(16)(17). Therefore, to determine whether some of the ultrasound findings are specific to PH or not, the controls will include three subgroups, that were pneumonia group, MAS group and normal lungs, respectively.…”

Section: Patientsmentioning

confidence: 99%

The specific signs of lung ultrasound to diagnose pulmonary hemorrhage of the newborns: Evidence from a multicenter retrospective case-control study

Liu

Chi

et al. 2023

Front. Pediatr.

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ObjectivesPulmonary hemorrhage (PH) is one kind of critical lung diseases in newborn infants, which is the most difficult one to be diagnosed by ultrasound. This study was to investigate the specific ultrasonic signs of PH in order to better diagnose neonatal PH by using lung ultrasound (LUS).MethodsA total 168 newborn infants were enrolled in this study, which included PH, pneumonia, meconium aspiration syndrome, and newborns without lung diseases, there were 42 cases in each group. In a quiet state, infants were placed in the supine, lateral or prone position for the examination. Each lung was divided into the anterior, lateral and posterior regions, then each region of both lungs was scanned with the probe perpendicular to the ribs or parallel to the Intercostal spaces.ResultsThe major results showed that: (1) the common LUS manifestation of PH includes lung consolidation, air bronchograms, fluid bronchograms, pleural effusion, shred signs, pleural line abnormality and B-lines, while fibrin deposition sign is a rare sign of PH. (2) Co-existing of lung consolidation with fluid bronchograms and pleural effusion is the specific sign of PH with a sensitivity of 81.0%, specificity of 98.4% and the positive predictive value (PPV) was 94.4%. (3) Fibrin deposition sign is an uncommon specific LUS sign of PH with a sensitivity 28.6%, specificity of 100% and the PPV was 100%. (4) Nine patients (21.4%) were diagnosed with PH based on ultrasound findings before oronasal bleeding. (5) The survival rate of infants with PH was 100% in this study.ConclusionLUS is helpful for the early diagnosis of neonatal PH and may therefore improve the prognosis. The lung consolidation with fluid bronchograms and pleural effusion as well as fibrin deposition sign are specific to diagnose PH by using LUS.

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Section: Patientsmentioning

confidence: 99%

The specific signs of lung ultrasound to diagnose pulmonary hemorrhage of the newborns: Evidence from a multicenter retrospective case-control study

Liu

Chi

et al. 2023

Front. Pediatr.

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“…A survey showed that pneumonia was the leading cause of death in extremely low birth weight infants, at approximately 22.5% 4 . As an auxiliary tool, lung ultrasound (LUS) has been increasingly used in the diagnosis of pneumonia in recent years and has good diagnostic performance 5–9 . It has become an international consensus method for the diagnosis of neonatal pneumonia 10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…4 As an auxiliary tool, lung ultrasound (LUS) has been increasingly used in the diagnosis of pneumonia in recent years and has good diagnostic performance. [5][6][7][8][9] It has become an international consensus method for the diagnosis of neonatal pneumonia. 10,11 Compared with chest X-ray, LUS has the advantages of no radiation, low cost, convenience, speed, and accuracy [12][13][14] and has higher diagnostic efficacy for pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Lung ultrasound to diagnose infectious pneumonia of newborns: A prospective multicenter study

Deng

Jiang

et al. 2022

Pediatric Pulmonology

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Introduction: Whether lung ultrasound (LUS) can be used for pathogenic diagnosis remains controversial. This study was conducted to clarify whether ultrasound has diagnostic value for etiology.Methods: A total of 135 neonatal pneumonia patients with an identified pathogen were enrolled from the newborn intensive care units of 10 tertiary hospitals in China. The study ran from November 2020 to December 2021. The infants were divided into various groups according to pathogens, time of infection, gestational age, and disease severity. The distribution of pleural line abnormalities, B-line signs, and pulmonary consolidation, as well as the incidence of air bronchogram and pleural effusion based on LUS, were compared between these groups.Results: There were significant differences in pulmonary consolidation. The sensitivity and specificity of the diagnosis of severe pneumonia based on the extent of pulmonary consolidation were 83.3% and 85.2%, respectively. The area under the receiver operating characteristic curve for the identification of mild or severe pneumonia based on the distribution of pulmonary consolidation was 0.776.

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“…The infant was followed up for nearly 12 months and experienced normal growth. Over the past decade, LUS has been widely used in the diagnosis and differential diagnosis of neonatal lung diseases [ 3 , 4 ], including neonatal pneumonia [ 5 , 6 , 7 ]. LUS has a number of advantages over CXR; it should serve as a complementary diagnostic method in providing accurate, timely and reliable information [ 8 , 9 ].…”

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confidence: 99%

“…In addition, the progressive exacerbation of lung disease due to a lack of timely and effective treatment may be one of the reasons for the extensive consolidation and severe atelectasis. Meanwhile, other types of bacterial pneumonitis are sensitive to commonly used antibiotics, respond well to treatment and rarely accumulate atelectasis throughout the lungs, although they also show consolidation on ultrasound [ 1 , 5 , 6 , 7 ]. The problems may be as following: (1) LUS may well detect atelectasis, infiltrations, pneumothorax, etc.…”

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confidence: 99%

Lung Ultrasound Monitoring of Legionella Ventilator-Associated Pneumonia in an Extremely Low-Birth-Weight Infant

Qiu

2022

Diagnostics

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Ventilator-associated pneumonia (VAP) is a common complication of different severe lung diseases that need to be treated with mechanical ventilation in newborn infants. However, VAP due to Legionella pneumophila infection is rarely reported in the literature, especially in extremely low-birth-weight (ELBW) infants. Lung ultrasound (LUS) has been used in the diagnosis of neonatal pneumonia, but there is no literature on the ultrasound characteristics of Legionella-VAP in ELBW infants. This paper introduced the typical LUS findings of Legionella-VAP in ELBW infants, which mainly includes severe and large-area lung consolidation and atelectasis in the bilateral lungs; whether there is blood supply in the consolidated area has an important reference value for predicting the prognosis. In addition, the treatment and management experience were also introduced together, thereby helping us to deepen the understanding of the disease and avoid missed diagnoses.

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Lung Ultrasound to Diagnose Pneumonia in Neonates with Fungal Infection

Cited by 10 publications

References 36 publications

The specific signs of lung ultrasound to diagnose pulmonary hemorrhage of the newborns: Evidence from a multicenter retrospective case-control study

The specific signs of lung ultrasound to diagnose pulmonary hemorrhage of the newborns: Evidence from a multicenter retrospective case-control study

Lung ultrasound to diagnose infectious pneumonia of newborns: A prospective multicenter study

Lung Ultrasound Monitoring of Legionella Ventilator-Associated Pneumonia in an Extremely Low-Birth-Weight Infant

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