Lung Ultrasound Surface Wave Elastography for Assessing Patients With Pulmonary Edema

Wiley, Brandon M.; Zhou, Boran; Pandompatam, Govind; Zhou, Jinling; Küçük, Hi̇lal Olgun; Zhang, Xiaoming

doi:10.1109/tbme.2021.3072891

Cited by 9 publications

(12 citation statements)

References 52 publications

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“…Moreover, it was applied only to rat lungs, which have different characteristics compared with humans (Mohanty et al 2017). On the other hand, Zhang et al tested LUSWE in human studies and obtained encouraging results in terms of differentiation between healthy participants and patients affected by different diseases (Zhang et al 2017(Zhang et al , 2019aWiley et al 2021). However, as suggested by an in vitro study (Zhou and Zhang 2018b), the positioning of the shaker could lead to strong variability in the findings and, thus, to less reliable results.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, no significant differences were reported between ILD patients with SSC and ILD patients without SSC (Zhang et al 2019b). The same group applied the LUSWE technique to perform two follow-up studies, aimed at assessing disease progression in patients with ILD (Zhang et al 2019a) and pulmonary edema (Wiley et al 2021). In both studies, correlations between changes in lung surface speed and clinical assessments were found, highlighting the possibility of using LUSWE for quantitative assessment of ILD and edema progression (Zhang et al 2019a;Wiley et al 2021).…”

Section: Quantitative Lus Imaging Human Clinical Studiesmentioning

confidence: 99%

“…This comparison could indeed allow researchers to study the link between the air spaces' (alveoli) resizing and spatial reorganization, as caused by different pathologies, and the quantifiable features of LUS artifacts (Soldati et al 2019(Soldati et al , 2020b. Then, these studies could be exploited to better comprehend LUS artifact genesis, allowing the development of quantitative LUS techniques aimed at estimating physical properties of lung surface (Demi et al 2017(Demi et al , 2020aMohanty et al 2017;Zhang et al 2017;Wiley et al 2021).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

State of the Art in Lung Ultrasound, Shifting from Qualitative to Quantitative Analyses

Mento¹,

Khan²,

Faita³

et al. 2022

Ultrasound in Medicine & Biology

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Section: Discussionmentioning

confidence: 99%

Section: Quantitative Lus Imaging Human Clinical Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

State of the Art in Lung Ultrasound, Shifting from Qualitative to Quantitative Analyses

Mento¹,

Khan²,

Faita³

et al. 2022

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

“…The number of characteristic reverberation artifacts (B-lines) corresponds to the amount of extravascular lung water. Lung ultrasound surface shear wave elastography has proven itself for the assessment of pulmonary edema in patients with acute congestive heart failure and could show a reduction in shear wave speed suggesting a decrease in stiffness according to positive therapy effects [ 60 ]. Actually, USE was used in adults for the diagnosis and management of pneumonia in the COVID-19 pandemic [ 27 ].…”

Section: Other Possible Applicationsmentioning

confidence: 99%

Ultrasound elastography in children — nice to have for scientific studies or arrived in clinical routine?

et al. 2022

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Ultrasound elastography (USE) is a modality that in addition to fundamental B-mode, Doppler, and contrast-enhanced sonography is suitable to make qualitative and quantitative statements about the stiffness of tissues. Introduced more than 20 years ago in adults, USE becomes now a diagnostic tool also in children. The aim of this paper is to describe current available techniques for USE in children. The significance for routine use in children is shown, and further interesting applications are reported.

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“…In these conditions, the prevalent subpleural distribution of lung abnormalities makes shear waves more easily detectable by ultrasound probes. Recent studies have also reported promis-ing data on the application of elastosonography in pulmonary edema [17] and COVID-19 pneumonia [18]. To date, transthoracic lung elastosonography has not been studied in patients with chronic obstructive pulmonary disease (COPD) yet.…”

Section: Introductionmentioning

confidence: 99%

Thoracic Ultrasound Strain Elastosonography as a Noninvasive Biomarker of Chronic Obstructive Pulmonary Disease-Associated Lung Injury: A Feasibility Study

et al. 2022

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Background: Transthoracic strain elastosonography (TSE) is being increasingly studied for estimating lung-pleura interface stiffness in pulmonary fibrosis. To date, no data exist on its application in chronic obstructive pulmonary disease (COPD). Objectives: The aim of this article was to describe the TSE pattern in patients with COPD and healthy subjects, either smokers or nonsmokers, and evaluate the feasibility of this technique for early detection of COPD in smokers. Methods: Nineteen patients with COPD, twenty-one healthy smokers, and twenty healthy nonsmokers underwent spirometry and TSE. Elastosonography was performed by one ultrasound-certified operator on 12 different scans for each participant, on right and left sides, anteriorly and posteriorly, on upper and lower lobes. For each scan, lung-pleura interface stiffness index (SI) was calculated, and the average SI on all 12 scans (SI-12) and on posterior basal scans (SI-PB) was calculated and used for comparisons among groups of participants and correlations with spirometric parameters. Results: Patients with lung injury (i.e., with COPD or healthy smokers) exhibited significantly increased lung-pleura interface stiffness on TSE, measured by SI-12 and SI-PB, than healthy nonsmokers (p < 0.05). Unlike SI-12, SI-PB was able to discriminate between subjects with lung injury and healthy nonsmokers on receiver operating characteristics analysis (area under the curve 0.846, 95% confidence interval 0.730–0.926, p < 0.001) and correlated with forced expiratory volume in the first second (r = −0.31, p = 0.018). Conclusion: The measurement of lung-pleura interface stiffness by TSE in posterior basal scans was able to discriminate patients with lung injury from healthy nonsmokers. The role of TSE for detecting early lung damage in COPD should be further investigated.

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Lung Ultrasound Surface Wave Elastography for Assessing Patients With Pulmonary Edema

Cited by 9 publications

References 52 publications

State of the Art in Lung Ultrasound, Shifting from Qualitative to Quantitative Analyses

State of the Art in Lung Ultrasound, Shifting from Qualitative to Quantitative Analyses

Ultrasound elastography in children — nice to have for scientific studies or arrived in clinical routine?

Thoracic Ultrasound Strain Elastosonography as a Noninvasive Biomarker of Chronic Obstructive Pulmonary Disease-Associated Lung Injury: A Feasibility Study

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